Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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Notice to Authors: NEW
Abstracts now required for Communications
To improve the discoverability of Communications, we ask authors to supply an abstract as the first paragraph from now on. In this abstract, the motivation for the work, the methods applied, the results, and the conclusions drawn should be presented (maximum 1000 characters).
“If I were not a scientist, I would be a businessman. I can never resist the taste of success. ...” This and more about Mohammad K. Nazeeruddin can be found on page 9419.
Reviews from Our Sister Journals
- Sven Kruspe, Florian Mittelberger, Kristina Szameit, Ulrich Hahn
Aptamers as Drug Delivery Vehicles
Selective delivery: Active drug targeting enhances the efficacy and specificity of systemic therapeutics. Aptamers, artificial nucleic acid ligands, represent powerful targeting tools that can act as cell-specific drug carriers. The advancements from the past decade have provided various approaches that open new gateways for drug administration in cancer therapy. [Review]
- Arunoday Bhan, Subhrangsu S. Mandal
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease [Review]
- Aurélie Blond, Eric Ennifar, Carine Tisné, Laurent Micouin
The Design of RNA Binders: Targeting the HIV Replication Cycle as a Case Study [Review]
- Paul Vogel, Thorsten Stafforst
Site-Directed RNA Editing with Antagomir Deaminases — A Tool to Study Protein and RNA Function [Concept]
- Akimitsu Okamoto
DNA–Osmium Complexes: Recent Developments in the Operative Chemical Analysis of DNA Epigenetic Modifications [Review]
- Jussara Amato, Nunzia Iaccarino, Antonio Randazzo, Ettore Novellino, Bruno Pagano
Noncanonical DNA Secondary Structures as Drug Targets: the Prospect of the i-Motif [Concept]
- Pengfei Zhan, Qiao Jiang, Zhen-gang Wang, Na Li, Haiyin Yu, Baoquan Ding
DNA Nanostructure-Based Imaging Probes and Drug Carriers [Minireview]
- Attilio V. Vargiu, Alessandra Magistrato
Atomistic-Level Portrayal of Drug–DNA Interplay: A History of Courtships and Meetings Revealed by Molecular Simulations [Review]
August 22, 2014
Angewandte Chemie 35/2014: Inspiration and Automation
In this issue, S. O. Krabbenborg and J. Huskens review the electrochemical generation of gradients. What benefits does this method offer with respect to the generation of dynamic solution and surface gradients, the integration of electronics, and compatibility with automation? In a Minireview, M. J. Krische et al. discuss catalytic enantioselective C–H functionalization of alcohols by redox-triggered carbonyl addition. The Highlight deals with thermoelectric tin selenide (H. Zhang and D. V. Talapin). In an Essay, K. C. Nicolaou inspires new drug development processes.
In the Communications section, U. Rieder and N. W. Luedtke use an inverse electron demand Diels–Alder reaction to enable time-resolved, multicolor labeling of DNA synthesis in individual cells (see picture). J. Šebestík and P. Bouř observed the paramagnetic Raman optical activity of nitrogen dioxide. R. Kinjo et al. report on the isolation of a bis(oxazol-2-ylidene)–phenylborylene adduct and its reactivity as a boron-centered nucleophile. P. J. Chirik et al. present photochemical reductive elimination as a route to a zirconocene complex with a strongly activated N2 ligand.
A Larger Pocket
Reprogramed nonribosomal peptide synthetase incorporates amino acids with reactive sites for “click” chemistry
A single targeted mutation is enough to alter a natural peptide system so that it also incorporates non-natural amino acids into peptides, report Swiss scientists in the journal Angewandte Chemie. The mutation increases the size of the binding cavity in one domain of the system, which changes the substrate specificity. The researchers are thus able to incorporate amino acids with a specific reactive group that can later be used to easily modify the peptide.
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