Angewandte Chemie International Edition
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Abstracts now required for Communications
To improve the discoverability of Communications, we ask authors to supply an abstract as the first paragraph from now on. In this abstract, the motivation for the work, the methods applied, the results, and the conclusions drawn should be presented (maximum 1000 characters).
“My greatest achievement is hopefully still to come from an unexpected observation. I lose track of time whenever I'm playing Bach ...” This and more about Nuno Maulide can be found on page 7984.
Reviews from Our Sister Journals
- Dina V. Hingorani, Byunghee Yoo, Adam S. Bernstein, Mark D. Pagel
Detecting Enzyme Activities with Exogenous MRI Contrast Agents
All with one basket: This review focuses on exogenous MRI contrast agents that are responsive to enzyme activity. Enzymes (signified by the basket in the figure) can catalyze a change in water access, rotational tumbling time, ligand proximity, aggregation state, chemical exchange rate, or the chemical shift of 19F, 31P, 13C, or a labile 1H of an agent, which can be used to detect enzyme activity. The variety of 49 agents attests to the creativity in developing enzyme-responsive MRI contrast agents. [Review]
- Mian He, Jean-François Soulé, Henri Doucet
Synthesis of (Poly)fluorobiphenyls through Metal-catalyzed C-H Bond Activation/Arylation of (Poly)fluorobenzene Derivatives [Review]
- Vikramaditya G. Yadav, Gregory Stephanopoulos
Metabolic Engineering: The Ultimate Paradigm for Continuous Pharmaceutical Manufacturing [Minireview]
- John Meurig Thomas
Heterogeneous Catalysis and the Challenges of Powering the Planet, Securing Chemicals for Civilised Life, and Clean Efficient Utilization of Renewable Feedstocks [Review]
- Irina V. Delidovich, Alexandr N. Simonov, Oxana P. Taran, Valentin N. Parmon
Catalytic Formation of Monosaccharides: From the Formose Reaction towards Selective Synthesis [Minireview]
- Francisco Pena-Pereira, Jacek Namiesnik
Ionic Liquids and Deep Eutectic Mixtures: Sustainable Solvents for Extraction Processes [Review]
- F. Ivy Carroll, Roland E. Dolle
The Discovery and Development of the N-Substituted trans-3,4-Dimethyl-4-(3'-hydroxyphenyl)piperidine Class of Pure Opioid Receptor Antagonists [Review]
- Lining Lu, Chenxu Zhu, Bo Xia, Chengqi Yi
Oxidative Demethylation of DNA and RNA Mediated by Non-Heme Iron-Dependent Dioxygenases [Focus Review]
July 30, 2014
Angewandte Chemie 31/2014: Sizzling Hot
In this issue, many contributions are dedicated to George Whitesides on the occasion of his 75th anniversary. R. Haag et al. review protein interactions with polymer coatings and biomaterials. What are the recent developments in analytics, biochemistry, and theory beyond Teflon? In a Minireview, E. Kumacheva et al. summarize microfluidic studies of carbon dioxide. The Highlight deals with crystal structures in light harvesting and charge separation in photosynthesis (O. Einsle).
In the Communications section, T. Ohba examines size-dependent water structures in carbon nanotubes (see picture). N. L. Abbott et al. report on the change in orientation of liquid crystals anchored on monolayers of chiral versus achiral molecules. M. Hartmann and A. Studer present the cyclizing radical carboiodination, carbotelluration, and carboaminooxylation of aryl amines, and K. O. Christie et al. succeeded in the preparation of trivalent and tetravalent manganese azides.
Hope for the Honey Bee?
Peptide-polyketide antibiotic from the pathogen that causes American Foulbrood
Infections with American foulbrood can destroy entire bee populations. A team of German and Dutch researchers has now isolated metabolic products of the pathogen that causes it, Paenibacillus larvae. The structures of the products have been identified, providing insights into the unusual biosynthetic pathways by which they are made. These new findings could help to clarify the mechanisms of infection and thus to find points of attack for effectively combating bee disease. As the researchers report in the journal Angewandte Chemie, these paenilamicins have antibiotic effects that may also be of use in human medicine.
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