Angewandte Chemie International Edition
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Recently Published Issues
“My favorite place on Earth is a good French brasserie. My not-so-secret passion is astrobiology ...” This and more about Roland Winter can be found on page 13374.
Angew. Chem. Int. Ed.2016, 55, No. 43, 13374–13374.
Robert G. Bergman, Rick L. Danheiser
Reproducibility in Chemical Research
“… To what extent is reproducibility a significant issue in chemical research? How can problems involving irreproducibility be minimized? … Researchers should be aware of the dangers of unconscious investigator bias, all papers should provide adequate experimental detail, and Reviewers have a responsibility to carefully examine papers for adequacy of experimental detail and support for the conclusions …” Read more in the Editorial by Robert G. Bergman and Rick L. Danheiser.
Angew. Chem. Int. Ed.2016, 55, No. 41, 12548–12549.
Reviews from Our Sister Journals
- Avinash H. Bansode, Prathyusha Chimala, Nitin T. Patil
Catalytic Branching Cascades in Diversity Oriented Synthesis
Branching cascades: The huge potential of diversity oriented synthesis (DOS) is currently being demonstrated by an upsurge of significant achievements. This has led to the development of several techniques to allow the rapid synthesis of several multifunctional polyheterocyclic scaffolds in an efficient manner. Described herein, a new technique of so-called “catalytic branching cascades” is shown to generate a large scaffold diversity. [Concept]
- Ligang Feng, Huaiguo Xue
Advances in Transition-Metal Phosphide Applications in Electrochemical Energy Storage and Catalysis [Minireview]
- Robert Thomas
Examination of Potential Exceptions to the F and S Biosynthetic Classification of Fused-Ring Aromatic Polyketides [Concept]
- Martin Pichette Drapeau, Lukas J. Gooßen
Carboxylic Acids as Directing Groups for C−H Bond Functionalization [Minireview]
- Melania Gómez-Martínez, Diego A. Alonso, Isidro M. Pastor, Gabriela Guillena, Alejandro Baeza
Organocatalyzed Assembly of Chlorinated Quaternary Stereogenic Centers [Focus Review]
- Yangyan Li, Wenbo Li, Junliang Zhang
Gold-Catalyzed Enantioselective Annulations [Review]
- Stanislav I. Sadovnikov, Aleksandr I. Gusev
Universal Approach to the Synthesis of Silver Sulfide in the Forms of Nanopowders, Quantum Dots, Core-Shell Nanoparticles, and Heteronanostructures [Microreview]
- Hisashi Shimakoshi, Yoshio Hisaeda
A Hybrid Catalyst for Light-Driven Green Molecular Transformations [Minireview]
The Nobel Prize in Chemistry 2016 was awarded to J.-P. Sauvage, J. F. Stoddart and B. L. Feringa. Read more at ChemistryViews.org.
The Angewandte team is proud to have published the first articles in the "accepted article" format: as-submitted, without translation, copy-editing, language polishing, or typesetting. These tasks will be carried out shortly and the article, in its "version of record", be moved to "EarlyView" before inclusion in an issue. In the meantime, the paper can already be studied, discussed, and even cited (by its DOI). At the moment, this procedure is reserved to reviews only.
If you are looking for the list of upcoming articles that used to be found under "Accepted Articles", please see "Articles Coming Soon".
October 21, 2016
Angewandte Chemie 44/2016: New Paradigms
In this issue, L. Yuan et al. review the imaging of chemistry in individual organelles with fluorescent probes. How can small-molecule probes be targeted to elucidate functionality? In a Minireview, S. P. Marsden et al. evaluate new chemistry to drive molecular discovery. The Highlight deals with the mechanism of biological methane-forming reactions (S. Shima). In his Editorial, Peter Gölitz discusses the development of Angewandte Chemie and editorial policies regarding color cost and preprints.
In the Communications section, C. J. H. Porter et al. present glyceride-mimetic prodrugs that avoid first-pass metabolism and enhance oral bioavailability (see picture). P. A. Levkin et al. succeeded in UV-induced disulfide formation and reduction for photopatterning. M. D. Smith et al. present a counterion-directed approach to the Diels–Alder paradigm: a cascade synthesis of tricyclic fused cyclopropanes.
Where Does Cisplatin Bind?
Identification of genome-wide cisplatin cross-linking sites with DNA base resolution
Cisplatin is one of the most widely used agents in cancer chemotherapy. Its mode of action is cross-linking of the DNA, which can kill cells. But which part of the genome is more affected, and which is less affected? A Chinese team of scientists have now set up a universal, genome-wide assay system to detect the specific cisplatin action sites, In the journal Angewandte Chemie the scientists introduce their system and report initial results, which support the notion that the mitochondrial genome is one of cisplatin's main targets.
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