Angewandte Chemie International Edition

• Cheng-Kui Pei, Min Shi
  Asymmetric Cyclization Reactions of Allenoates with Imines or α,β-Unsaturated Ketones Catalyzed by Organocatalysts Derived from Cinchona Alkaloids
  
  Asymmetric organocatalysis: Lewis base-catalyzed cyclization reactions of allenoates with electron-deficient olefins and imines have been applied in the preparation of biologically active natural products and pharmaceutically interesting substances and have emerged as powerful synthetic tools in the rapid construction of cyclic molecular complexity. In contrast to phosphine-containing Lewis bases, nitrogen-containing Lewis base amines display markedly different reaction profiles; however, this area is not well-developed. [Concept]
• Stefan K. Henninger, Felix Jeremias, Harry Kummer, Christoph Janiak
  MOFs for Use in Adsorption Heat Pump Processes [Microreview]
• Juliusz A. Wolny, Rolf Diller, Volker Schünemann
  Vibrational Spectroscopy of Mono- and Polynuclear Spin-Crossover Systems [Microreview]
• Sinéad E. Milner, Thomas S. Moody, Anita R. Maguire
  Biocatalytic Approaches to the Henry (Nitroaldol) Reaction [Microreview]
• Frances Heaney
  Nitrile Oxide/Alkyne Cycloadditions – A Credible Platform for Synthesis of Bioinspired Molecules by Metal-Free Molecular Clicking [Microreview]
• Roy N. Dsouza, Andreas Hennig, Werner M. Nau
  Supramolecular Tandem Enzyme Assays [Concept]
• Hannah Gelman, Max Platkov, Martin Gruebele
  Rapid Perturbation of Free-Energy Landscapes: From In Vitro to In Vivo [Concept]
• Yoshiyuki Hari, Satoshi Obika, Takeshi Imanishi
  Towards the Sequence-Selective Recognition of Double-Stranded DNA Containing Pyrimidine-Purine Interruptions by Triplex-Forming Oligonucleotides [Microreview]

Planned Coincidence

Antibody-based search for new chemical reactions

Many discoveries are made by chance, but it is also possible to help it along: The chance of finding something interesting increases when the number of experiments rises. French researchers have now applied this principle to the search for new chemical reactions. In the journal Angewandte Chemie, they have introduced a new concept based on antibodies and a “sandwich” immunoassay.

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alkynes · asymmetric catalysis · asymmetric synthesis · C-H activation · copper · cycloaddition · density functional calculations · electrochemistry · fluorescence · gold · heterocycles · heterogeneous catalysis · homogeneous catalysis · magnetic properties · nanoparticles · nanostructures · natural products · NMR spectroscopy · organocatalysis · oxidation · palladium · peptides · polymers · rhodium · ruthenium · self-assembly · structure elucidation · supramolecular chemistry · synthetic methods · total synthesis