Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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Abstracts now required for Communications
To improve the discoverability of Communications, we ask authors to supply an abstract as the first paragraph from now on. In this abstract, the motivation for the work, the methods applied, the results, and the conclusions drawn should be presented (maximum 1000 characters).
“If I were not a scientist, I would be a businessman. I can never resist the taste of success. ...” This and more about Mohammad K. Nazeeruddin can be found on page 9419.
Reviews from Our Sister Journals
- Sven Kruspe, Florian Mittelberger, Kristina Szameit, Ulrich Hahn
Aptamers as Drug Delivery Vehicles
Selective delivery: Active drug targeting enhances the efficacy and specificity of systemic therapeutics. Aptamers, artificial nucleic acid ligands, represent powerful targeting tools that can act as cell-specific drug carriers. The advancements from the past decade have provided various approaches that open new gateways for drug administration in cancer therapy. [Review]
- Arunoday Bhan, Subhrangsu S. Mandal
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease [Review]
- Aurélie Blond, Eric Ennifar, Carine Tisné, Laurent Micouin
The Design of RNA Binders: Targeting the HIV Replication Cycle as a Case Study [Review]
- Paul Vogel, Thorsten Stafforst
Site-Directed RNA Editing with Antagomir Deaminases — A Tool to Study Protein and RNA Function [Concept]
- Akimitsu Okamoto
DNA–Osmium Complexes: Recent Developments in the Operative Chemical Analysis of DNA Epigenetic Modifications [Review]
- Jussara Amato, Nunzia Iaccarino, Antonio Randazzo, Ettore Novellino, Bruno Pagano
Noncanonical DNA Secondary Structures as Drug Targets: the Prospect of the i-Motif [Concept]
- Pengfei Zhan, Qiao Jiang, Zhen-gang Wang, Na Li, Haiyin Yu, Baoquan Ding
DNA Nanostructure-Based Imaging Probes and Drug Carriers [Minireview]
- Attilio V. Vargiu, Alessandra Magistrato
Atomistic-Level Portrayal of Drug–DNA Interplay: A History of Courtships and Meetings Revealed by Molecular Simulations [Review]
August 29, 2014
Angewandte Chemie 36/2014: Click to Synthesize
In this issue, K. B. Sharpless et al. review the sulfur(VI) fluoride exchange reaction (SuFEx): In what way is it another good reaction for click chemistry? The Highlight deals with the remote functionalization of C–H bonds (M. Beller et al.).
In the Communications section, A. Friedler et al. describe a tandem in situ peptide cyclization through trifluoroacetic acid cleavage (see picture). S.-G. He et al. report on the thermal methane conversion to formaldehyde by single platinum atoms located in cluster anions. C. J. Yang et al. succeeded in the preparation of a nanomicelle for real-time imaging and NIR cancer therapy. Sharpless, Fokin et al. present a synthesis of polysulfates by applying SuFEx click chemistry.
A Small Golden Cosmos
Planet–satellite nanostructures from gold nanoparticles and RAFT star polymers
The cosmos in miniature: German researchers have produced nanoparticles surrounded by a group of smaller nanoparticles like a planet orbited by satellites. They equipped larger gold nanoparticles with special star-shaped polymers, which in turn bind to smaller gold nanoparticles. As the researchers report in the journal Angewandte Chemie, it is possible to precisely control the distance between the tiny “satellites” and their central “planet” by means of the molecular weight—and thus the chain length—of the polymers.
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