An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides
Dr. Wael E. Houssen, Andrew F. Bent, Dr. Andrew R. McEwan, Nathalie Pieiller, Dr. Jioji Tabudravu, Dr. Jesko Koehnke, Greg Mann, Rosemary I. Adaba, Dr. Louise Thomas, Dr. Usama W. Hawas, Dr. Huanting Liu, Dr. Ulrich Schwarz-Linek, Prof. Margaret C. M. Smith, Prof. James H. Naismith and Prof. Marcel Jaspars
Article first published online: 21 OCT 2014 | DOI: 10.1002/anie.201408082
Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry, but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds using a set of engineered marine-derived enzymes and substrates.