Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems
Xiaoxuan Liu, Jiehua Zhou, Tianzhu Yu, Chao Chen, Qiang Cheng, Kheya Sengupta, Yuanyu Huang, Haitang Li, Cheng Liu, Yang Wang, Paola Posocco, Menghua Wang, Qi Cui, Suzanne Giorgio, Maurizio Fermeglia, Fanqi Qu, Sabrina Pricl, Yanhong Shi, Zicai Liang, Palma Rocchi, John J. Rossi and Ling Peng
Article first published online: 12 SEP 2014 | DOI: 10.1002/anie.201406764
Vesicle-like dendrimersomes formed through the self-assembly of an amphiphilic dendrimer are able to undergo structural rearrangement into spherical micelles to entrap and condense siRNA into stable nanoparticles, which protect siRNA and promote siRNA delivery in various cells including human primary and stem cells as well as in vivo. This system combines the advantages of lipid and dendrimer vectors, hence constituting a novel and efficient siRNA delivery platform.