Mannose-6-Phosphate Receptor: A Target for Theranostics of Prostate Cancer
Dr. Ophélie Vaillant, Dr. Khaled El Cheikh, Dr. David Warther, Dr. David Brevet, Dr. Marie Maynadier, Dr. Elise Bouffard, Dr. Frédéric Salgues, Dr. Audrey Jeanjean, Dr. Pierre Puche, Dr. Catherine Mazerolles, Dr. Philippe Maillard, Dr. Olivier Mongin, Dr. Mireille Blanchard-Desce, Dr. Laurence Raehm, Dr. Xavier Rébillard, Dr. Jean-Olivier Durand, Dr. Magali Gary-Bobo, Dr. Alain Morère and Dr. Marcel Garcia
Article first published online: 20 MAR 2015 | DOI: 10.1002/anie.201500286
On target: The over-expression of a mannose-6-phosphate receptor was demonstrated in prostate tissues and cancer cell lines. This receptor was targeted with a mannose-6-phosphate analogue grafted onto the surface of mesoporous silica nanoparticles (MSNs). MSNs were efficient for cancer imaging and therapy, thus demonstrating the potential of M6PR targeting for prostate cancer theranostics.