In Vivo Gold Complex Catalysis within Live Mice
Kazuki Tsubokura, Dr. Kenward K. H. Vong, Dr. Ambara R. Pradipta, Dr. Akihiro Ogura, Sayaka Urano, Dr. Tsuyoshi Tahara, Dr. Satoshi Nozaki, Dr. Hirotaka Onoe, Dr. Yoichi Nakao, Regina Sibgatullina, Dr. Almira Kurbangalieva, Dr. Yasuyoshi Watanabe and Dr. Katsunori Tanaka
Version of Record online: 15 FEB 2017 | DOI: 10.1002/anie.201610273
The first metal-catalyzed reaction that proceeds within live mice is based on a targeting approach with glycans. Glycoalbumin–AuIII complexes can be accumulated in specific organs where they catalyze amide bond formation between a propargyl ester probe and amine groups on nearby proteins. The selective targeting was confirmed by whole body fluorescence imaging and analysis of dissected tissues.