Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 31

Early View (Online Version of Record published before inclusion in an issue)

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

  1. Communications

    1. Layered Hybrid Materials

      You have full text access to this OnlineOpen article
      Single-Layered Hybrid Materials Based on 1D Associated Metalorganic Nanoribbons for Controlled Release of Pheromones

      José María Moreno, Dr. Ismael Navarro, Dr. Urbano Díaz, Prof. Jaime Primo and Prof. Avelino Corma

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201602215

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      Come into my layer: Layered organic–inorganic materials, based on ordered nickel-nanoribbons separated by alkyl arylic mono-carboxylate spacers located perpendicular to the 1D inorganic chains, act as a matrix for the controlled release of active principles (pheromones) in environmentally friendly pest management.

    2. Plastics Substitutes | Hot Paper

      Hydrogels from Amorphous Calcium Carbonate and Polyacrylic Acid: Bio-Inspired Materials for “Mineral Plastics”

      Dr. Shengtong Sun, Li-Bo Mao, Zhouyue Lei, Prof. Dr. Shu-Hong Yu and Prof. Dr. Helmut Cölfen

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201602849

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      Shapeable, stretchable, recyclable, (thermochromic) amorphous calcium carbonate-based hybrid supramolecular hydrogels were synthesized, which can reversibly form macroscopic rigid transparent films upon drying. This plastic material may potentially replace conventional plastics in a move towards solving environmental issues.

    3. Fischer–Tropsch Synthesis

      Highly Tunable Selectivity for Syngas-Derived Alkenes over Zinc and Sodium-Modulated Fe5C2 Catalyst

      Peng Zhai, Cong Xu, Dr. Rui Gao, Dr. Xi Liu, Mengzhu Li, Weizhen Li, Xinpu Fu, Prof. Chunjiang Jia, Jinglin Xie, Ming Zhao, Dr. Xiaoping Wang, Prof. Yong-Wang Li, Prof. Qianwen Zhang, Prof. Xiao-Dong Wen and Prof. Ding Ma

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201603556

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      Direct synthesis of olefins using Fe-based catalysts is a component of the traditional Fischer–Tropsch process. Na-doping of Fe catalysts alters the surface electronic structure, which promotes CO activation and desorption of products, while suppressing hydrogenation of double bonds. A Na-modulated catalyst is especially selective for alkenes (particularly C5+).

    4. Natural Product Synthesis

      The Enantioselective Total Synthesis of Exochomine

      Alison X. Gao, Dr. Tomoaki Hamada and Prof. Dr. Scott A. Snyder

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201604744

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      Challenging chirality: Use of a distinct synthetic strategy to address the challenges in merging two different halves bearing a chiral center at their merger point has enabled access to the alkaloid exochomine in 16 steps. Key operations include the functionalization of a hindered iminium precursor, a unique aldol-based coupling cascade, and a robust protocol for 1,4-reduction in a hindered context where numerous side-reactions can occur.

    5. Carbonylation

      Carbonylation of Difluoroalkyl Bromides Catalyzed by Palladium

      Hai-Yang Zhao, Zhang Feng, Zhiji Luo and Prof. Dr. Xingang Zhang

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201605380

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      Insertion of CO: A palladium-catalyzed carbonylation reaction of difluoroalkyl halides into ketones was developed (see picture). The resulting difluoroalkyl ketones can serve as versatile building blocks for the synthesis of useful fluorinated compounds.

  2. Cover Pictures

    1. Divergent Coordination Chemistry: Parallel Synthesis of [2×2] Iron(II) Grid-Complex Tauto-Conformers

      Dr. Bernhard Schäfer, Dr. Jean-François Greisch, Dr. Isabelle Faus, Dr. Tilmann Bodenstein, Dr. Ivan Šalitroš, Dr. Olaf Fuhr, Priv.-Doz. Dr. Karin Fink, Prof. Dr. Volker Schünemann, Prof. Dr. Manfred M. Kappes and Prof. Dr. Mario Ruben

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201606094

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      Divergent coordination chemistry is featured by two, in parallel synthesized tauto-isomeric FeII4L4 tetramers which differ strongly in their magnetic behavior. In their Communication (10.1002/anie.201603916), M. Ruben et al. report how tautomerism of a homoditopic ligand leads during FeII ion coordination to the emergence of both diversity and complexity on the molecular level. In the background, the Asura statue from the year 734, placed in Kōfuku-ji, Nara, Japan, symbolizes the chaos-creating good–evil dichotomy in an ever complex world by showing three faces and six arms.

  3. Reviews

    1. Sensors

      Single-Molecule Sensors: Challenges and Opportunities for Quantitative Analysis

      Prof. J. Justin Gooding and Katharina Gaus

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201600495

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      More than the sum of its parts: Advances in measurement science have seen a progressive reduction in sample size to the point that single-molecule measurements are today commonplace. A new generation of sensors is expected that perform quantitative analysis by measuring many single-molecule events. This Review discusses the challenges, opportunities, and recent developments in quantitative single-molecule sensors.

  4. Communications

    1. Chirality

      The Interplay Between Conformation and Absolute Configuration in Chiral Electron Dynamics of Small Diols

      Dr. Steven Daly, Dr. Maurice Tia, Dr. Gustavo A. Garcia, Dr. Laurent Nahon and Prof. Dr. Ivan Powis

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201603771

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      Methyl substitution at a terminal carbon of 1,3-propanediol creates a new stereogenic center, and hence permanent R and S configurational enantiomers of 1,3-butanediol. However, the HOMO electron dynamics are predicted to continue displaying marked conformational pseudo-enantiomerism analogous to the transient conformational chirality in 1,3-propanediol.

    2. Glycans

      Highly Efficient Synthesis of Multiantennary Bisected N-glycans Based on Imidates

      Manuel Mönnich, Dr. Steffen Eller, Theodoros Karagiannis, Lukas Perkams, Thomas Luber, Dr. Dimitri Ott, Dr. Mathäus Niemietz, Dr. Joanna Hoffman, Janika Walcher, Lukas Berger, Dr. Matthias Pischl, Markus Weishaupt, Cathrin Wirkner, Prof. Rachel G. Lichtenstein and Prof. Carlo Unverzagt

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201604190

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      Bisecting á la carte: A general and robust modular approach to bisected N-glycans was established based on a unified protecting-group pattern. The switch to N-TFAc protection of the donors for the antennae provides high yields for the difficult late-stage introduction of a bisecting GlcNAc. Regardless of the number of antennae, a judicious choice of imidate activation permits the highly efficient one-pot synthesis of bisected N-glycans.

    3. Molecular Electronics

      Gradients of Rectification: Tuning Molecular Electronic Devices by the Controlled Use of Different-Sized Diluents in Heterogeneous Self-Assembled Monolayers

      Gyu Don Kong, Miso Kim, Soo Jin Cho and Prof. Hyo Jae Yoon

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201604748

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      Rectifying defects: A detailed study of the electrical behavior of binary surface-assembled monolayers (SAMs) composed of an organic rectifier, SC11BIPY, and non-rectifying n-alkanethiolate diluents shows that the gradient behavior of rectification can be finely tuned by controlling the structure (specifically, the molecular length) of the diluent.

    4. Indole Alkaloids

      Total Synthesis of Notoamides F, I, and R and Sclerotiamide

      Benxiang Zhang, Dr. Weifeng Zheng, Dr. Xiaoqing Wang, Dr. Deqian Sun and Prof. Dr. Chaozhong Li

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201604754

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      Just a hop, skip, and a jump: The title compounds were synthesized in only 10–12 steps from the Seebach acetal. The synthetic approach features an oxidative aza-Prins cyclization to construct the bicyclo[2.2.2]diazaoctane in a highly stereoselective manner and a cobalt-catalyzed radical cycloisomerization to build the cyclohexenyl ring.

    5. Synthetic Methods

      Oxidative Difunctionalization of Alkenyl MIDA Boronates: A Versatile Platform for Halogenated and Trifluoromethylated α-Boryl Ketones

      Wen-Xin Lv, Yao-Fu Zeng, Dr. Qingjiang Li, Dr. Yunyun Chen, Dong-Hang Tan, Ling Yang and Prof.Dr. Honggen Wang

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201604898

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      α-Boryl ketone synthesis: A one-pot oxidative difunctionalization of alkenyl MIDA boronates for the syntheses of densely functionalized α-boryl ketones was developed. The presence of multiple functional groups within the same molecule confers on these products great synthetic utility, as demonstrated by the successful synthesis of borylated furans.

    6. Two-Dimensional Nanomaterials

      Controlled Gas Exfoliation of Boron Nitride into Few-Layered Nanosheets

      Dr. Wenshuai Zhu, Dr. Xiang Gao, Dr. Qian Li, Dr. Hongping Li, Dr. Yanhong Chao, Dr. Meijun Li, Dr. Shannon M. Mahurin, Prof. Huaming Li, Dr. Huiyuan Zhu and Prof. Sheng Dai

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201605515

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      Layered structures: A novel and efficient thermal-expansion-triggered gas exfoliation of boron nitride into few-layered nanosheets was successfully developed (see picture). This method can also be used to produce other layered materials in high yields.

    7. N-Glycopeptide Synthesis

      N-Linked Glycosyl Auxiliary-Mediated Native Chemical Ligation on Aspartic Acid: Application towards N-Glycopeptide Synthesis

      Hua Chai, Dr. Kim Le Mai Hoang, Minh Duy Vu, Dr. Kalyan Pasunooti, Prof. Dr. Chuan-Fa Liu and Prof. Dr. Xue-Wei Liu

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201605597

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      A practical approach towards N-glycopeptide synthesis using an auxiliary-mediated dual native chemical ligation (NCL) has been developed. The first NCL connects an N-linked glycosyl auxiliary to the thioester side chain of an N-terminal aspartate oligopeptide. This intermediate undergoes a second NCL with a C-terminal thioester oligopeptide. Mild cleavage provides the desired N-glycopeptide.

    8. Carbon Nanohorns | Hot Paper

      Individualized p-Doped Carbon Nanohorns

      Anastasios Stergiou, Dr. Zheng Liu, Dr. Bin Xu, Dr. Toshiro Kaneko, Dr. Christopher P. Ewels, Dr. Kazu Suenaga, Dr. Minfang Zhang, Dr. Masako Yudasaka and Dr. Nikos Tagmatarchis

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201605644

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      I am an individual: A facile approach for the separation of aggregated carbon nanohorns (CNHs), by treatment with chlorosulfonic acid, leads to p-doped species. The acid induces positive charges on the nanohorns which repel and push the individual nanohorns apart. The method yields gram quantities of free nanohorns.

    9. Water Oxidation

      Thin Heterojunctions and Spatially Separated Cocatalysts To Simultaneously Reduce Bulk and Surface Recombination in Photocatalysts

      Ang Li, Xiaoxia Chang, Zhiqi Huang, Chengcheng Li, Yijia Wei, Dr. Lei Zhang, Dr. Tuo Wang and Prof. Dr. Jinlong Gong

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201605666

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      Mesoporous hollow spheres with the composition Pt@TiO2@In2O3@MnOx can absorb both UV and visible light. Owing to the presence of thin heterojunctions and spatially separated cocatalysts, charge recombination is efficiently reduced in both the bulk phase and the surface/subsurface. These hollow spheres can be used as efficient photocatalysts for water and alcohol oxidation.

    10. Sulfoximidation

      Synthesis of Sulfoximidoyl-Containing Hypervalent Iodine(III) Reagents and Their Use in Transition-Metal-Free Sulfoximidations of Alkynes

      Han Wang, Ying Cheng, Dr. Peter Becker, Prof. Dr. Gerhard Raabe and Prof. Dr. Carsten Bolm

      Version of Record online: 22 JUL 2016 | DOI: 10.1002/anie.201605743

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      Stable sulfoximidoyl-containing hypervalent iodine(III) reagents were prepared and their structural properties were analyzed through X-ray crystal structure determination of a representative product and theoretical investigations. The reactivity of the new compounds led to an unprecedented transition-metal-free approach towards N-alkynylated sulfoximines.

    11. Heterocycles | Very Important Paper

      Medium-Ring Nitrogen Heterocycles through Migratory Ring Expansion of Metalated Ureas

      Jessica E. Hall, Dr. Johnathan V. Matlock, Dr. John W. Ward, Katharine V. Gray and Prof. Jonathan Clayden

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201605714

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      Ringing in ureas: Simple benzo-fused nitrogen heterocycles (indolines, tetrahydroquinolines, and their homologues) undergo migratory ring expansion under basic conditions to generate a range of medium-ring nitrogen heterocycles with ring sizes of 8–12. Considerable complexity is rapidly generated in an efficient synthesis of these otherwise difficult-to-obtain rings.

  5. Cover Pictures

    1. You have free access to this content
      Porous Molybdenum Phosphide Nano-Octahedrons Derived from Confined Phosphorization in UIO-66 for Efficient Hydrogen Evolution

      Jian Yang, Fengjun Zhang, Xin Wang, Dongsheng He, Geng Wu, Qinghua Yang, Xun Hong, Yuen Wu and Yadong Li

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201606586

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      The confinement effect of metal–organic frameworks (MOFs) allows MoO2 nanoparticles@porous carbon to be fabricated by subliming MoO3 into the pores of the MOF UIO-66. The resulting MoO2 nanoparticles (NPs) were converted into MoP at 850 °C by PH3 which was generated in situ. In their Communication (DOI: 10.1002/anie.201604315) Y. Wu, Y. Li, and co-workers show that using this strategy, MoP NPs confined in porous carbon are obtained and exhibit higher hydrogen evolution reaction (HER) activity than bulk MoP.

    2. You have free access to this content
      Hydrogels from Amorphous Calcium Carbonate and Polyacrylic Acid: Bio-Inspired Materials for “Mineral Plastics”

      Dr. Shengtong Sun, Li-Bo Mao, Zhouyue Lei, Prof. Dr. Shu-Hong Yu and Prof. Dr. Helmut Cölfen

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201606536

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      Mineral plastics may bring new hope to solve current environmental issues, such as “white pollution”. In their Communication (10.1002/anie.201602849) H. Cölfen and co-workers report a bio-inspired hydrogel material composed of very small amorphous calcium carbonate nanoparticles and poly(acrylic acid). The hydrogel is shapeable and self-healable like the character “Barbapapa” and can reversibly form macroscopic rigid transparent films upon drying.

    3. You have free access to this content
      Synthesis of Graphene Oxide by Oxidation of Graphite with Ferrate(VI) Compounds: Myth or Reality?

      Prof. Dr. Zdeněk Sofer, Jan Luxa, Dr. Ondřej Jankovský, Prof. Dr. David Sedmidubský, Dr. TomአBystroň and Prof. Dr. Martin Pumera

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201606630

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      Ferrate or not ferrate that is the question. Recently, the synthesis of graphene oxide using potassium ferrate(VI) ions has been reported. In their Communication (10.1002/anie.201603496) Z. Sofer, M. Pumera, and co-workers critically replicate and evaluate the new ferrate(VI) oxidation method. In addition, they test the use of potassium ferrate(VI) for the synthesis of graphene oxide under various experimental routes. The oxidation of graphite by ferrate(VI) is shown to be impossible owing to its fast decomposition in an acidic environment.

  6. Communications

    1. Organic Semiconductors | Hot Paper

      Wide Band-Gap Bismuth-based p-Dopants for Opto-Electronic Applications

      Dr. Sébastien Pecqueur, Anna Maltenberger, Prof. Dr. Marina A. Petrukhina, Prof. Dr. Marcus Halik, Prof. Dr. Arndt Jaeger, Dr. Dominik Pentlehner and Dr. Günter Schmid

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201601926

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      Bi doping: Ten new efficient p-dopants for conductivity doping of organic semiconductors for OLEDs are identified. The key advantage of the electrophilic tris(carboxylato)bismuth(III) compounds is the unique low absorption of the resulting doped layers. The combination of this feature with their low fabrication cost, volatility, and stability, make these materials very attractive as dopants in organic electronics.

    2. C−H Activation

      Overcoming the Limitations of C−H Activation with Strongly Coordinating N-Heterocycles by Cobalt Catalysis

      Hui Wang, Dr. Mélanie M. Lorion and Prof. Dr. Lutz Ackermann

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201603260

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      Strongly coordinating nitrogen heterocycles are fully tolerated by a versatile cobalt-catalyzed C−H amidation method, which provides access to structurally complex quinazolines. The powers of various directing groups in cobalt-catalyzed C−H activation were thus delineated.

    3. Metal–Organic Materials | Hot Paper

      Tuning Pore Size in Square-Lattice Coordination Networks for Size-Selective Sieving of CO2

      Dr. Kai-Jie Chen, Dr. David G. Madden, Dr. Tony Pham, Katherine A. Forrest, Amrit Kumar, Dr. Qing-Yuan Yang, Dr. Wei Xue, Prof. Dr. Brian Space, Dr. John J. Perry IV, Prof. Dr. Jie-Peng Zhang, Prof. Dr. Xiao-Ming Chen and Prof. Dr. Michael J. Zaworotko

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201603934

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      Sieves you right: Crystal engineering of supramolecular isomers of [Cu(quinoline-5-carboxyate)2]n metal–organic materials enables the right pore-chemistry for ultra-high CO2/N2 and CO2/CH4 selectivity even in the presence of water vapor.

    4. Mesoporous Metals

      Tunable-Sized Polymeric Micelles and Their Assembly for the Preparation of Large Mesoporous Platinum Nanoparticles

      Bo Jiang, Dr. Cuiling Li, Jing Tang, Dr. Toshiaki Takei, Prof. Jung Ho Kim, Dr. Yusuke Ide, Dr. Joel Henzie, Dr. Satoshi Tominaka and Prof. Yusuke Yamauchi

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201603967

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      Dancing to a different tune: Platinum nanoparticles with continuously tunable mesoporous structures were prepared by a one-step approach based on polymeric micelles. Their particle and pore sizes were controlled by altering the solvent composition (see picture). By virtue of their high surface area, these mesoporous Pt structures were more efficient electrocatalysts for methanol oxidation than commercially available Pt catalysts.

    5. Heterogeneous Catalysis

      Unraveling the Catalytic Synergy between Ti3+ and Al3+ Sites on a Chlorinated Al2O3: A Tandem Approach to Branched Polyethylene

      Alessandro Piovano, Dr. K. S. Thushara, Dr. Elena Morra, Prof. Mario Chiesa and Dr. Elena Groppo

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201604136

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      Working side by side: Branched polyethylene was synthesized using a catalyst consisting of Ti3+ and Al3+ sites on chlorinated alumina. Spectroscopic and physicochemical characterization showed that the catalytic sites act synergistically to promote the olefin conversion.

    6. Responsive Materials

      Light-Induced Water Splitting Causes High-Amplitude Oscillation of pH-Sensitive Layer-by-Layer Assemblies on TiO2

      Sviatlana A. Ulasevich, Prof. Gerald Brezesinski, Prof. Helmuth Möhwald, Prof. Peter Fratzl, Prof. Felix H. Schacher, Dr. Sergey K. Poznyak, Dr. Daria V. Andreeva and Dr. Ekaterina V. Skorb

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201604359

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      Water splitting for polymer actuation: A simple light-induced pH change, causes high amplitude oscillation of the thickness and stiffness of a polymer film deposited on a TiO2 surface. Irradiation of the TiO2 surface causes a charge separation, leading to water splitting and to a pH change. Unexpectedly the pH value could be reduced to pH 4, it could be localized by focusing of light, maintained over hours, and effected repeatedly and reversibly.

    7. Protein Modification | Very Important Paper

      A Modular Method for the High-Yield Synthesis of Site-Specific Protein–Polymer Therapeutics

      Dr. Yan Pang, Dr. Jinyao Liu, Yizhi Qi, Dr. Xinghai Li and Prof. Ashutosh Chilkoti

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201604661

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      The site-specific and stoichiometric synthesis of protein/peptide–polymer therapeutics in high yield is enabled by a modular method that is based on a combination of recombinant expression, enzyme-mediated ligation, and click chemistry. This approach is suitable for the conjugation of structurally diverse polymers to various protein and peptide drugs.

    8. Gas-Phase Reactions | Hot Paper

      Reactions between Criegee Intermediates and the Inorganic Acids HCl and HNO3: Kinetics and Atmospheric Implications

      Elizabeth S. Foreman, Kara M. Kapnas and Dr. Craig Murray

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201604662

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      Novel sink for Criegee intermediates: The rate constants for the reaction of the simplest Criegee intermediate, CH2OO, with HCl (in green) and HNO3 (in blue) were directly measured by broadband transient absorption spectroscopy. Both reactions occur at or near the collision limit, as was also confirmed by quantum-chemical calculations.

    9. Concentration Cells

      Magnetic Cobalt Ferrite Nanocrystals For an Energy Storage Concentration Cell

      Dr. Qilin Dai, Ketan Patel, Greg Donatelli and Prof. Shenqiang Ren

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201604790

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      CoFe2O4 nanocrystals with controlled size and magnetic properties were synthesized. The energy storage performance of concentration cells is dictated by the magnetic characteristics of the cobalt ferrite nanocrystal carriers.

    10. Coordination Chemistry | Hot Paper

      Simplest Monodentate Imidazole Stabilization of the oxy-Tyrosinase Cu2O2 Core: Phenolate Hydroxylation through a CuIII Intermediate

      Dr. Linus Chiang, William Keown, Dr. Cooper Citek, Dr. Erik C. Wasinger and Prof. T. Daniel P. Stack

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201605159

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      Cold copper cores: Three Nτ-imidazole-bonded CuII2O2 species were synthesized and characterized at low solution temperatures. These complexes resemble the catalytic cores of tyrosinases, and allowed phenolate-ligated CuIII intermediates during hydroxylation reactions to be probed, providing insights into the enzymatic mechanisms.

    11. Posttranslational Modifications

      Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine

      Dr. Maria Matveenko, Dr. Elena Cichero, Prof. Dr. Paola Fossa and Prof. Dr. Christian F. W. Becker

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201605366

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      Underinvestigated protein modifications: The non-enzymatic posttranslational modification (nPTM) argpyrimidine (Apy) was incorporated into Hsp27 through protein semisynthesis, and the impact was investigated at the molecular level. Apy was found to reduce Hsp27 chaperone activity and oligomerization, without affecting folding. This suggests that nPTMs are able to alter protein function.

    12. Hydrosilylation of Alkynes

      Highly Chemo-, Regio-, and Stereoselective Cobalt-Catalyzed Markovnikov Hydrosilylation of Alkynes

      Jun Guo and Prof. Zhan Lu

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201605501

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      Cobalt catalysis: A highly chemo-, regio- and stereoselective cobalt-catalyzed hydrosilylation reaction of alkynes with silanes was developed (see picture; HBPin=pinacol borane; TOF=turnover frequency). The reaction tolerates various functionalized groups, which may lead to further applications and late-stage derivatizations.

    13. Epigenetics | Hot Paper

      An Epigenetics-Inspired DNA-Based Data Storage System

      Dr. Clemens Mayer, Dr. Gordon R. McInroy, Dr. Pierre Murat, Dr. Pieter Van Delft and Prof. Shankar Balasubramanian

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201605531

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      Information storage: Inspired by the epigenetic regulation of genomic information in cells, it is shown how digital data can undergo controlled changes when encoded in synthetic DNA strands. Chemical transformations were used to alter naturally occurring cytosine derivatives, which enabled the reversible recovery of multiple data layers from a single DNA template (see portraits).

    14. Uranium MOFs

      Design and Synthesis of a Water-Stable Anionic Uranium-Based Metal–Organic Framework (MOF) with Ultra Large Pores

      Dr. Peng Li, Dr. Nicolaas A. Vermeulen, Xirui Gong, Dr. Christos D. Malliakas, Prof. J. Fraser Stoddart, Prof. Joseph T. Hupp and Prof. Omar K. Farha

      Version of Record online: 21 JUL 2016 | DOI: 10.1002/anie.201605547

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      Stuck on U: Large cationic dyes and enzymes are adsorbed selectively over their anionic counterparts by a water-stable anionic mesoporous metal–organic framework (MOF) based on uranium.

  7. Essays

    1. Citation Ethics

      Homo Citans and Carbon Allotropes: For an Ethics of Citation

      Dr. Roald Hoffmann, Dr. Artyom A. Kabanov, Andrey A. Golov and Prof. Davide M. Proserpio

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201600655

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      Cite we must, cite we do. We cite because we are links in a chain, using properties and methods validated by others. We also cite to negotiate the anxiety of influence. And to be fair. After outlining the reasons for citation, we use two case studies of citation amnesia in the field of hypothetical carbon allotropes to present a computer-age search tool (SACADA) in that subsubfield. Finally, we advise on good search practice, including what to do if you miss a citation.

  8. Reviews

    1. Metabolic Glycoengineering

      Metabolic Glycoengineering with N-Acyl Side Chain Modified Mannosamines

      Paul R. Wratil, Prof. Dr. Rüdiger Horstkorte and Prof. Dr. Werner Reutter

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201601123

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      Sugar for cells: Metabolic glycoengineering is a method to incorporate modified monosaccharides into cells, organs, or animals. Unnatural sialic acids can be generated by treatment with N-acyl side chain modified mannosamines. The application of this technique has intriguing biological consequences for treated cells. Mannosamine analogues bearing reactive groups can be used, for example, to visualize sialylated glycoconjugates.

    2. Avermectins

      A Splendid Gift from the Earth: The Origins and Impact of the Avermectins (Nobel Lecture)

      Prof. Dr. Satoshi Ōmura

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201602164

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      Japanese soil was the origin of one of the most important drugs of the world: ivermectin. No other drug has such importance for the health of millions of people, particularly in the poor regions of the world. The discovery of the parent compounds of the avermectines is described first hand by S. Ōmura.

  9. Communications

    1. Cross-Coupling

      Versatile C(sp2)−C(sp3) Ligand Couplings of Sulfoxides for the Enantioselective Synthesis of Diarylalkanes

      William M. Dean, Mindaugas Šiaučiulis, Dr. Thomas E. Storr, Dr. William Lewis and Prof. Robert A. Stockman

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201602264

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      On three: The reaction of chiral (hetero)aryl benzyl sulfoxides with Grignard reagents affords diarylalkanes with greater than 99.5 % enantiomeric excess. The reaction is tolerant to multiple substitution patterns and proceeds in three operationally simple steps from commercially available reagents. This strategy provides orthogonal access to electron-deficient heteroaromatic compounds.

  10. Minireviews

    1. Nonribosomal Peptide Synthesis

      You have full text access to this OnlineOpen article
      New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis

      Tiia Kittilä, Aurelio Mollo, Dr. Louise K. Charkoudian and Dr. Max J. Cryle

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201602614

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      Have substrate, will travel: Nonribosomal peptide synthetases (NRPSs) show great potential for the generation of new bioactive molecules, however, a detailed model describing the NRPS mechanism is still lacking. Recent characterization of several multidomain NRPS structures has expanded our understanding of essential peptide carrier protein interactions and movements during NRPS catalysis.

  11. Communications

    1. Carbenes

      Synthesis of α-Fluoroketones by Insertion of HF into a Gold Carbene

      Xiaojun Zeng, Shiwen Liu, Zhenyu Shi, Guangchang Liu and Dr. Bo Xu

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201603914

      Thumbnail image of graphical abstract

      An HF insert: Insertion of hydrogen fluoride (HF) into a metal carbene is a new approach in transition metal catalyzed fluorination and provides an efficient synthesis of α-fluoroketones. This method gives excellent chemical yields for wide range of alkyne substrates.

    2. Rust as Electrodes

      In Situ Activating Ubiquitous Rust towards Low-Cost, Efficient, Free-Standing, and Recoverable Oxygen Evolution Electrodes

      Haixia Zhong, Jun Wang, Fanlu Meng and Prof. Dr. Xinbo Zhang

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201604040

      Thumbnail image of graphical abstract

      To turn waste into treasure, rusty stainless steel is recycled into low-cost, efficient, free-standing oxygen evolution reaction (OER) electrodes via an electrochemical oxidation–reduction cycle in an electrolyte.

    3. Molecular Shuttles

      Selective Nitrate Recognition by a Halogen Bonding Four Station [3]Rotaxane Molecular Shuttle

      Timothy A. Barendt, Andrew Docker, Igor Marques, Prof. Vítor Félix and Prof. Paul D. Beer

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201604327

      Thumbnail image of graphical abstract

      Anion sandwich is a pincer cake: The synthesis of the first halogen bonding (XB) [3]rotaxane host system containing a four station axle is reported. Anion binding titration experiments reveal the rotaxane is selective for nitrate and operates through a dynamic pincer mechanism in which both macrocycles shuttle to the central XB anion recognition sites to form a 1:1 stoichiometric oxoanion–rotaxane sandwich complex.

    4. Dual Catalysis

      Highly Chemoselective Iridium Photoredox and Nickel Catalysis for the Cross-Coupling of Primary Aryl Amines with Aryl Halides

      Dr. Martins S. Oderinde, Natalie H. Jones, Antoine Juneau, Prof. Mathieu Frenette, Dr. Brian Aquila, Sharon Tentarelli, Dr. Daniel W. Robbins and Dr. Jeffrey W. Johannes

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201604429

      Thumbnail image of graphical abstract

      Lights, metal, action: A visible-light-promoted dual-catalytic cross-coupling procedure combining Ir photoredox catalysis and Ni catalysis to form C−N bonds has been developed. This mild and operationally simple method proceeds at room temperature without rigorous exclusion of O2 and was employed for the cross-coupling of various aryl amines with electronically and sterically diverse aryl iodides and bromides.

    5. Sequential Catalysis | Very Important Paper

      A Metalloregulated Four-State Nanoswitch Controls Two-Step Sequential Catalysis in an Eleven-Component System

      M.Sc. Sudhakar Gaikwad, M.Sc. Abir Goswami, Dr. Soumen De and Prof. Dr. Michael Schmittel

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201604658

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      Connect four: The first nanoswitch with four states can control a sequential transformation A+B+C[RIGHTWARDS ARROW]AB+C[RIGHTWARDS ARROW]ABC with 11 components over two complete cycles. The cycle proceeds stepwise along the switching states OFF1[RIGHTWARDS ARROW]ON1 (click reaction: A+B[RIGHTWARDS ARROW]AB)[RIGHTWARDS ARROW]OFF2[RIGHTWARDS ARROW]ON2 (Michael addition: AB+C[RIGHTWARDS ARROW]ABC)[RIGHTWARDS ARROW]OFF1 (see scheme). The system′s preformance is superior to that of systems with only two switching states.

    6. Organocatalysis

      Asymmetric Synthesis of Spirobenzazepinones with Atroposelectivity and Spiro-1,2-Diazepinones by NHC-Catalyzed [3+4] Annulation Reactions

      Dr. Lei Wang, Sun Li, Marcus Blümel, Arne R. Philipps, Ai Wang, Dr. Rakesh Puttreddy, Prof. Dr. Kari Rissanen and Prof. Dr. Dieter Enders

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201604819

      Thumbnail image of graphical abstract

      Spiro via [3+4]: The asymmetric NHC-catalyzed [3+4] annulation of isatin-derived enals and aryl sulfonamides or tosyl hydrazones leads to spirobenzazepinones with atroposelectivity, or to spiro-1,2-diazepinones bearing an oxindole moiety in high yields and excellent enantioselectivities with a wide variety of substrates.

    7. Multicomponent Catalysis

      Catalytic Enantioselective Conjugate Additions of (pin)B-Substituted Allylcopper Compounds Generated in situ from Butadiene or Isoprene

      Dr. Xiben Li, Dr. Fanke Meng, Dr. Sebastian Torker, Ying Shi and Prof. Amir H. Hoveyda

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201605001

      Thumbnail image of graphical abstract

      Catalysis with feedstock: Abundantly available butadiene and isoprene together with commercially available B2(pin)2 participate in enantioselective multicomponent conjugate addition to enoates. Transformations are catalyzed by a copper complex of an easily accessible NHC (N-heterocyclic carbene) ligand, affording products in up to 83 % yield, 80:20 Z:E and 98:2 e.r.

    8. Enantioselective Synthesis

      Mixed Aggregates of the Dilithiated Koga Tetraamine: NMR Spectroscopic and Computational Studies

      Dr. Yun Ma, Kyle A. Mack, Dr. Jun Liang, Dr. Ivan Keresztes, Prof. David B. Collum and Prof. Armen Zakarian

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201605199

      Thumbnail image of graphical abstract

      Koga's chiral dilithium amide used in asymmetric synthesis is shown to promiscuously form mixed aggregates with a wide variety of lithium salts including those containing halides, alkoxides, acetylides, and amides. Although largely isostructural, the presence or absence of Li−X transannular contacts distinguishes ladder from cyclic motifs.

    9. Dehydrogenative Cross-Coupling

      Cobalt-Catalyzed C−H Thiolation through Dehydrogenative Cross-Coupling

      Tobias Gensch, Felix J. R. Klauck and Prof. Dr. Frank Glorius

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201605193

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      Co-laboration! A new method for the dehydrogenative cross-coupling of thiols and indoles features a novel mode of action for the cobalt-catalyzed formation of a C−heteroatom bond. Mechanistic studies indicate a sequence of C−H activation, thiolate transfer, and reductive elimination.

    10. Diazo Compounds

      Selective Synthesis of Six Products from a Single Indolyl α-Diazocarbonyl Precursor

      Michael J. James, Prof. Peter O'Brien, Prof. Richard J. K. Taylor and Dr. William P. Unsworth

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201605337

      Thumbnail image of graphical abstract

      Pick a catalyst: Indolyl α-diazocarbonyls can be selectively cyclized to give six distinct products through the careful choice of the catalyst and reaction conditions. A range of catalysts were used, including complexes of RhII, PdII, and CuII as well as SiO2, to promote diazo decomposition and subsequent cyclization/rearrangement through a range of mechanistic pathways.

    11. Energetic Materials | Very Important Paper

      Synthesis of Tetrazino-tetrazine 1,3,6,8-Tetraoxide (TTTO)

      Dr. Michael S. Klenov, Alexey A. Guskov, Dr. Oleg V. Anikin, Prof. Dr. Aleksandr M. Churakov, Dr. Yurii A. Strelenko, Dr. Ivan V. Fedyanin, Dr. Konstantin A. Lyssenko and Prof. Dr. Vladimir A. Tartakovsky

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201605611

      Thumbnail image of graphical abstract

      A butterfly-like high-nitrogen structure: A ten-step synthesis of TTTO (see picture) was accomplished. The synthetic strategy was based on the sequential closure of two 1,2,3,4-tetrazine 1,3-dioxide rings by the generation of oxodiazonium ions and their intramolecular coupling with tert-butyl-NNO-azoxy groups. TTTO is considered as a new high-energy compound.

  12. Cover Pictures

    1. You have free access to this content
      Asymmetric Ring Opening/Cyclization/Retro-Mannich Reaction of Cyclopropyl Ketones with Aryl 1,2-Diamines for the Synthesis of Benzimidazole Derivatives

      Yong Xia, Dr. Lili Lin, Fenzhen Chang, Yuting Liao, Prof. Dr. Xiaohua Liu and Prof. Dr. Xiaoming Feng

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201606534

      Thumbnail image of graphical abstract

      The first asymmetric ring-opening/cyclization/retro-Mannich reaction of cyclopropyl ketones with aryl-1,2-diamines is described by X. M. Feng and co-workers in their Communication (10.1002/anie.201604735). The construction of benzimidazole backbones and establishing the stereochemistry in their side chains are accomplished in only one step in the presence of a N,N′-dioxide/ScIII complex. “The carp has leaped through the dragon's gate” means success in a Chinese saying. The N,N′-dioxide/ScIII complex is the dragon's gate, the reagents are the carp, and the successfully generated product is the dragon.

    2. You have free access to this content
      A Description of Vibrational Modes in Hexaphyrins: Understanding the Aromaticity Reversal in the Lowest Triplet State

      Dr. Young Mo Sung, Juwon Oh, Koji Naoda, Dr. Taegon Lee, Woojae Kim, Prof. Dr. Manho Lim, Prof. Dr. Atsuhiro Osuka and Prof. Dr. Dongho Kim

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201606588

      Thumbnail image of graphical abstract

      Vibrational spectroscopy sheds light on the relationship between the changes in the molecular structures and aromaticity reversal. Compared to the relatively simple IR spectra of aromatic hexaphyrins, those of antiaromatic hexaphyrins show complex IR spectra, which reflects an interrelation between the aromaticity reversal and structural changes. In their Communication (10.1002/anie.201603631) D. Kim et al. analyze this aromaticity reversal by using IR spectroscopic techniques and quantum calculations.

  13. Communications

    1. Synthetic Methods | Very Important Paper

      Regioselective Transition-Metal-Free Allyl–Allyl Cross-Couplings

      Mario Ellwart, Dr. Ilya S. Makarov, Dr. Florian Achrainer, Prof. Dr. Hendrik Zipse and Prof. Dr. Paul Knochel

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201603923

      Thumbnail image of graphical abstract

      One of four possible products: Cross-coupling reactions of allylic zinc halides with allylic bromides provide 1,5-dienes with high regioselectivity. Various functional groups (ester, nitrile) are tolerated. Propargylic and benzylic halides can be used in this transformation. DFT calculations confirm the importance of LiCl for the efficient cross-coupling.

    2. Nucleotide Labelling

      Covalent Chemical 5′-Functionalization of RNA with Diazo Reagents

      Dr. Christian M. Gampe, Micah Hollis-Symynkywicz and Dr. Frédéric Zécri

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201604385

      Thumbnail image of graphical abstract

      Conditions for selective alkylation of the 5′-phosphate of native RNA in aqueous media are reported. This method was applied to functionalize an oligonucleotide with both biotin and a small molecule that endowed the RNA with binding affinity to the eukaryotic initiation factor 4E (eIF4E), thus confirming the ability to modulate RNA properties and suggesting applications in mRNA therapy.

    3. Metathesis

      FeCl3-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis

      Lina Ma, Wenjuan Li, Hui Xi, Xiaohui Bai, Enlu Ma, Dr. Xiaoyu Yan and Prof. Dr. Zhiping Li

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201604349

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      Ironing it out: The title reaction allows access to a range of carbo-/heterocyclic alkenes. The reaction is proposed to take place by FeCl3-catalyzed oxetane formation followed by retro-ring-opening to deliver the metathesis products.

    4. Supported Catalysis

      Molecular Engineering of Trifunctional Supported Catalysts for the Aerobic Oxidation of Alcohols

      Dr. Antony E. Fernandes, Prof. Olivier Riant, Prof. Klavs F. Jensen and Prof. Alain M. Jonas

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201603673

      Thumbnail image of graphical abstract

      A simple and modular strategy is reported for the preparation and engineering of trifunctional supported catalysts bearing Cu, TEMPO, and NMI sites for application in the aerobic oxidation of alcohols. Variation of the linker length on the NMI component and optimization of surface composition allowed synergistic interactions to be tailored for optimal activity and recycling.

    5. Crystal Growth

      Realignment of Nanocrystal Aggregates into Single Crystals as a Result of Inherent Surface Stress

      Zhaoming Liu, Dr. Haihua Pan, Genxing Zhu, Yaling Li, Dr. Jinhui Tao, Biao Jin and Prof. Ruikang Tang

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201603794

      Thumbnail image of graphical abstract

      Fall in! During random-attachment-based crystal growth, it was found that the evolution of crystal orientation is driven by the inherent surface stress, which eventually generates a single crystal (see picture). This mechanism is corroborated by measurements of orientation rate versus stress, for which a predictive relationship was identified.

    6. Surface Chemistry

      Catalytic Dealkylation of Ethers to Alcohols on Metal Surfaces

      Biao Yang, Haiping Lin, Kangjian Miao, Pan Zhu, Liangbo Liang, Kewei Sun, Dr. Haiming Zhang, Dr. Jian Fan, Prof. Vincent Meunier, Prof. Youyong Li, Dr. Qing Li and Prof. Lifeng Chi

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201602414

      Thumbnail image of graphical abstract

      On-surface dealkylation: The dealkylation reaction from ethers to alcohols is controllably realized through on-surface synthesis techniques. This reaction was shown to be surface-assisted and universal for alkoxybenzene-containing ethers.

    7. Molecular Switches | Hot Paper

      Fluorinated Azobenzenes for Shape-Persistent Liquid Crystal Polymer Networks

      Supitchaya Iamsaard, Emmanuel Anger, Sarah Jane Aßhoff, Alexis Depauw, Prof. Dr. Stephen P. Fletcher and Prof. Dr. Nathalie Katsonis

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201603579

      Thumbnail image of graphical abstract

      Liquid crystal polymers that contain fluorinated azobenzenes and retain a photochemically generated shape for more than eight days are reported. To preserve photoactivated molecular deformation on the macroscopic scale, the thermal stability of the photoswitch, the cross-linking density in the polymer network, and the molecular orientations in the material have been optimized.

    8. Azapentacene

      The Radical Anion and Dianion of Tetraazapentacene

      Dr. Lei Ji, Dr. Martin Haehnel, Dr. Ivo Krummenacher, Dr. Philipp Biegger, Florian L. Geyer, Olena Tverskoy, Dr. Manuel Schaffroth, Jie Han, Prof. Dr. Andreas Dreuw, Prof. Dr. Todd B. Marder and Prof. Dr. Uwe H. F. Bunz

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201603177

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      Charged but not pinned down! The reduction of the symmetrical tetraazapentacene with potassium metal in THF gives the radical anion, a species critical in charge transport in field effect transistors. The negative charge is shown to be equally distributed over the whole molecule and not localized or pinned on the electronegative nitrogen atoms.

    9. Gold Catalysis

      Well-Defined Dinuclear Gold Complexes for Preorganization-Induced Selective Dual Gold Catalysis

      Vincent Vreeken, Dr. Daniël L. J. Broere, Anne C. H. Jans, Marianne Lankelma, Prof. Dr. Joost N. H. Reek, Dr. Maxime A. Siegler and Dr. Jarl Ivar van der Vlugt

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201603938

      Thumbnail image of graphical abstract

      Worth its weight in gold: Coordination of gold(I) to a rigid bis(o-tolylamino)diphosphine ligand allows for versatile chemistry, including the isolation of a mixed-valent AuI–AuIII species. Halide abstraction induces ligand-to-gold two-electron transfer, producing a carbazolyldiphosphine analogue with a bridging chlorido ligand. This preorganized AuI–AuI species enables σ,π-activation of alkynes and is an isolable precatalyst for highly selective heterocyclizations.

    10. Nucleic Acid Computation

      Towards a DNA Nanoprocessor: Reusable Tile-Integrated DNA Circuits

      Dr. Yulia V. Gerasimova and Dr. Dmitry M. Kolpashchikov

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201603265

      Thumbnail image of graphical abstract

      AND and NOR on DNA: Arrays of communicating DNA logic gates integrated in a single DNA tile were produced. The gates can process nucleic acid inputs in a reusable format.

    11. Silver Clusters

      Unprecedented Efficient Structure Controlled Phosphorescence of Silver(I) Clusters Stabilized by Carba-closo-dodecaboranylethynyl Ligands

      Michael Hailmann, Natalia Wolf, Rebecca Renner, Thomas C. Schäfer, Benjamin Hupp, Dr. Andreas Steffen and Prof. Dr. Maik Finze

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201604198

      Thumbnail image of graphical abstract

      Six silver(I) clusters with five electronically different pyridine ligands were obtained starting from the silver(I) alkynyl {Ag2(12-C≡C-closo-1-CB11H11)}n. All of the clusters show room-temperature phosphorescence, which is highly unusual for this class of compounds. A distorted pentagonal bipyramidal AgI7 cluster with 3,5-lutidine gave a quantum yield of Φ=0.76, unprecedented for AgI clusters.

    12. Oligosaccharide Synthesis

      Reagent-Controlled α-Selective Dehydrative Glycosylation of 2,6-Dideoxy- and 2,3,6-Trideoxy Sugars

      Dr. Jason M. Nogueira, Marissa Bylsma, Danielle K. Bright and Prof. Clay S. Bennett

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/anie.201605091

      Thumbnail image of graphical abstract

      No directors needed! A combination of cyclopropene-1-thione 1 and oxalyl bromide promotes reagent-controlled dehydrative glycosylation reactions with 2,6-dideoxy- and 2,3,6-trideoxy-sugar donors in good yield and high selectivity (see Scheme). The best selectivity is observed with secondary acceptors. Orthogonal protecting groups on the donor are tolerated, allowing the reaction to be used in oligosaccharide synthesis.

    13. Cyclic Hexapeptides

      Dehydromicrosclerodermin B and Microsclerodermin J: Total Synthesis and Structural Revision

      Ekaterina Y. Melikhova, Dr. Robert D. C. Pullin, Dr. Christian Winter and Prof. Timothy J. Donohoe

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201604764

      Thumbnail image of graphical abstract

      Not your everyday AAs: Efficient approaches to the unusual amino acids in the title compounds were developed on the basis of the Negishi coupling (for the Trp-2-CO2H) and the Blaise reaction (for the pyrrolidinone unit). The original assignment of the pyrrolidinone stereostructure was confirmed to be incorrect by the synthesis of epimers, whose spectroscopic data were in complete agreement with those for the natural isolates (see structure).

    14. Synthetic methods

      Electrophilic Cyanation of Boron Enolates: Efficient Access to Various β-Ketonitrile Derivatives

      Dr. Kensuke Kiyokawa, Takaya Nagata and Prof. Dr. Satoshi Minakata

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201605445

      Thumbnail image of graphical abstract

      Plus CN: The title reaction proceeds with readily available cyanating reagents, N-cyano-N-phenyl-p-toluenesulfonamide and p-toluenesulfonyl cyanide. Various β-ketonitriles can be prepared by this new protocol, which shows a remarkably broad substrate scope compared to existing methods. The present method also allowed efficient synthesis of β-ketonitriles bearing a quaternary α-carbon center.

  14. Highlights

    1. Cross-Coupling

      Decarboxylative Alkyl–Alkyl Cross-Coupling Reactions

      Mikhail O. Konev and Prof. Dr. Elizabeth R. Jarvo

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201605593

      Thumbnail image of graphical abstract

      Alkyl with alkyl: A significant development in alkyl–alkyl cross-coupling reactions, namely the nickel-catalyzed decarboxylative Negishi coupling of N-hydroxyphthalimide esters, was recently reported by Baran and co-workers. This method enables the synthesis of various highly functionalized compounds, including natural product derivatives.

  15. Editorials

    1. You have free access to this content
      Chemists Creating a European Identity through Conferences and Journals

      Prof. Dr. Luis A. Oro

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201605628

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      “ … The 6th EuCheMS Chemistry Congress will take place in Seville in September 2016. EuCheMS represents more than 160 000 chemists from more than 40 member societies. ChemPubSoc Europe is an organization of 16 European chemical societies from 15 countries. These initiatives have contributed significantly to the creation of a European identity for chemistry …” Read more in the Editorial by Luis A. Oro.

  16. Cover Pictures

    1. You have free access to this content
      Thermoset Shape-Memory Polyurethane with Intrinsic Plasticity Enabled by Transcarbamoylation

      Ning Zheng, Zizheng Fang, Weike Zou, Prof. Qian Zhao and Prof. Tao Xie

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201606585

      Thumbnail image of graphical abstract

      The traditional Chinese art of paper cutting, Jianzhi, which is also known as kirigami, generates beautiful and sophisticated patterns. In their Communication (DOI: 10.1002/anie.201602847), Q. Zhao, T. Xie et al. made use of the Jianzhi technique to obtain classical thermoset polyurethanes with complex three-dimensional shapes. The thermoset polymer has intrinsic plasticity and can be permanently and repeatedly reshaped in the solid state through a topological network rearrangement that is induced by transcarbamoylation.

    2. You have free access to this content
      Flexible Zirconium Metal-Organic Frameworks as Bioinspired Switchable Catalysts

      Shuai Yuan, Lanfang Zou, Dr. Haixia Li, Ying-Pin Chen, Dr. Junsheng Qin, Dr. Qiang Zhang, Dr. Weigang Lu, Prof. Dr. Michael B. Hall and Prof. Dr. Hong-Cai Zhou

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201606587

      Thumbnail image of graphical abstract

      Switchable catalysis in flexible MOFs is possible through the inherent cavities and dynamic behaviors of flexible metal–organic frameworks (MOFs), namely the PCN-700 series, properties which bear a close resemblance to those of regulatory enzymes. In their Communication (10.1002/anie.201604313), W. Lu, M. B. Hall, H.-C. Zhou, and co-workers show that manual control of the catalytic properties of these MOFs is possible through reversible pore opening and closing.

  17. Communications

    1. Electrode Materials

      Topotactic Consolidation of Monocrystalline CoZn Hydroxides for Advanced Oxygen Evolution Electrodes

      Dr. Jing Wang, Chuan Fu Tan, Dr. Ting Zhu and Prof. Dr. Ghim Wei Ho

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201605096

      Thumbnail image of graphical abstract

      Tactical topology: A topotactic consolidation of cobalt and zinc constituents into monocrystalline CoZn hydroxide nanosheets is demonstrated for direct electrochemical oxygen evolution reactions.

    2. NMR Spectroscopy

      Recovering Invisible Signals by Two-Field NMR Spectroscopy

      Samuel F. Cousin, Dr. Pavel Kadeřávek, Baptiste Haddou, Dr. Cyril Charlier, Thorsten Marquardsen, Jean-Max Tyburn, Dr. Pierre-Alain Bovier, Dr. Frank Engelke, Dr. Werner Maas, Prof. Dr. Geoffrey Bodenhausen, Dr. Philippe Pelupessy and Prof. Dr. Fabien Ferrage

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201602978

      Thumbnail image of graphical abstract

      A two-field NMR spectrometer was designed to excite and observe nuclear spins in two distinct magnetic fields in a single experiment. This approach enables the detection of narrow resonances that are broadened beyond recognition at high fields because of internal dynamics.

    3. Aluminum/Sulfur Batteries | Hot Paper

      A Rechargeable Al/S Battery with an Ionic-Liquid Electrolyte

      Tao Gao, Xiaogang Li, Xiwen Wang, Dr. Junkai Hu, Fudong Han, Dr. Xiulin Fan, Dr. Liumin Suo, Alex J Pearse, Prof. Sang Bok Lee, Prof. Gary W. Rubloff, Dr. Karen J Gaskell, Dr. Malachi Noked and Prof. Chunsheng Wang

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201603531

      Thumbnail image of graphical abstract

      An ionic-liquid electrolyte is employed to give a rechargeable Al/S battery . The hurdle for oxidizing AlSx is addressed by using a microporous carbon/sulfur cathode that can improve the electron access of sulfur species, enlarge interfacial reaction area, and reduce the Al3+ diffusion length (<2 nm). Experimental results indicate that sulfur undergoes solid state conversion reaction in the electrolyte.

    4. Biomass Conversion

      Simultaneous H2 Generation and Biomass Upgrading in Water by an Efficient Noble-Metal-Free Bifunctional Electrocatalyst

      Dr. Bo You, Nan Jiang, Xuan Liu and Dr. Yujie Sun

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201603798

      Thumbnail image of graphical abstract

      A strategy for simultaneous H2 production and biomass valorization with high energy conversion efficiency is reported for coupling 5-hydroxymethylfurfural oxidation and H2 generation in water catalyzed by a nonprecious bifunctional electrocatalyst, Ni2P nanoparticle arrays coated on nickel foam. This strategy could provide a low-cost and energy-efficient alternative to standard electrocatalysts.

    5. Isoporphyrins

      Metal-Assisted One-Pot Synthesis of Isoporphyrin Complexes

      Dr. Peter Schweyen, Martin Hoffmann, Jens Krumsieck, Dr. Benedikt Wolfram, Dr. Xiulan Xie and Prof. Dr. Martin Bröring

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201604297

      Thumbnail image of graphical abstract

      Old synthesis, new tricks: Isoporphyrins form in unprecedented amounts if the long-established Adler–Longo condensation for tetraarylporphyrin synthesis is performed in the presence of metal acetates as template agents. The isoporphyrins formed by this one-pot method are surprisingly stable and show the anticipated long-wavelength absorption typical for this class of porphyrinoids.

    6. Charged Droplets | Hot Paper

      Solid-to-Liquid Charge Transfer for Generating Droplets with Tunable Charge

      Yajuan Sun, Xu Huang and Prof. Siowling Soh

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201604378

      Thumbnail image of graphical abstract

      Charged water: When water droplets flow across surfaces that have been charged by contact electrification, the droplets also become charged. Depending on the charge of the surface, the polarity and magnitude of the charge of the droplets can be controlled. The charge allows the droplets to be manipulated, coalesced, and sorted. This method for generating charged droplet is general, simple and inexpensive.

    7. Planar Chirality

      A Family of Chiral Ferrocenyl Diols: Modular Synthesis, Solid-State Characterization, and Application in Asymmetric Organocatalysis

      Chris Nottingham, Helge Müller-Bunz and Patrick J. Guiry

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201604840

      Thumbnail image of graphical abstract

      Triple crown of chirality: Reported is the synthesis of a novel family of chiral ferrocenyl diols possessing planar, central, and axial chirality. X-ray crystallography reveals dense intra- and intermolecular hydrogen-bond networks. The potential of these diols as organocatalysts was demonstrated in an asymmetric hetero-Diels–Alder reaction, thus providing cycloadducts in up to 84 % yield with ee values ranging from −92 to +72 %.

    8. Isomerization

      Rhodium-Catalyzed Asymmetric Cycloisomerization and Parallel Kinetic Resolution of Racemic Oxabicycles

      Dr. Charles C. J. Loh, Matthias Schmid, Dr. Robert Webster, Andy Yen, Shabnam K. Yazdi, Dr. Patrick T. Franke and Prof. Dr. Mark Lautens

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201604937

      Thumbnail image of graphical abstract

      The oxabicycle dance! An unprecedented rhodium-catalyzed cycloisomerization of meso-oxabicyclic alkenes bearing bis-tethered nucleophiles is presented. A parallel kinetic resolution was also demonstrated, where racemic oxabicycles bearing two different tethered nucleophiles can be resolved enantioselectively to give two constitutional isomers by differential nucleophilic attack.

  18. Cover Pictures

    1. You have free access to this content
      Hierarchically Mesoporous o-Hydroxyazobenzene Polymers: Synthesis and Their Applications in CO2 Capture and Conversion

      Guipeng Ji, Dr. Zhenzhen Yang, Dr. Hongye Zhang, Dr. Yanfei Zhao, Dr. Bo Yu, Zhishuang Ma and Prof. Dr. Zhimin Liu

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201604911

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      Hierarchically mesoporous o-hydroxyazobenzene polymers with high surface areas are synthesized without any templates in water. In their Communication (10.1002/anie.201602667), Z. M. Liu and co-workers show that these kinds of porous polymers have multiple functions including excellent dispersity in polar and apolar solvents, good chelation to metal ions (Zn2+, Cu2+, etc.), ultrahigh selectivity for CO2/N2 separation, and excellent performance for catalyzing CO2 conversion.

  19. Communications

    1. Copper Complexes

      Dispersion-Force-Assisted Disproportionation: A Stable Two-Coordinate Copper(II) Complex

      Clifton L. Wagner, Dr. Lizhi Tao, Emily J. Thompson, Dr. Troy A. Stich, Dr. Jingdong Guo, Dr. James C. Fettinger, Prof. Louise A. Berben, Prof. R. David Britt, Prof. Shigeru Nagase and Prof. Philip P. Power

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201605061

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      Straight-up copper: The synthesis of the first linear CuII complex Cu{N(SiMe3)Dipp}2 (Dipp=C6H5-2,6Pri2) and its CuI counterpart [Cu{N(SiMe3)Dipp}2] is described. The former, studied by EPR spectroscopy, forms through a dispersion force-driven disproportionation, and is the reaction product of a CuI halide and LiN(SiMe3)Dipp in a non-donor solvent. The latter forms by preventing the disproportionation by using the complexing agent 15-crown-5.

    2. Noncanonical Amino Acids

      Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins

      Dr. Weimin Xuan, Jack Li, Xiaozhou Luo and Prof. Peter G. Schultz

      Version of Record online: 15 JUL 2016 | DOI: 10.1002/anie.201604891

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      A handy handle: A novel noncanonical amino acid (ncAA) that contains an aryl isothiocyanate group was genetically incorporated into proteins in E. coli. This ncAA allows the selective conjugation of proteins to amine-containing molecules through formation of a thiourea bridge. It was also used to form intra- and intermolecular protein crosslinks through reaction with proximal Lys residues.

    3. Supramolecular Chemistry

      A Halogen-Bond-Induced Triple Helicate Encapsulates Iodide

      Casey J. Massena, Nicholas B. Wageling, Daniel A. Decato, Enrique Martin Rodriguez, Ariana M. Rose and Prof. Dr. Orion B. Berryman

      Version of Record online: 14 JUL 2016 | DOI: 10.1002/anie.201605440

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      Bond, halogen bond: Three tricationic arylethynyl strands self-assemble to form a tubular anion channel lined with nine halogen-bond donors in solution and the solid state. Eight strong iodine⋅⋅⋅iodide halogen bonds and numerous buried π-surfaces endow the triplex with remarkable stability, even at elevated temperatures. The stringent linearity of halogen bonding could be a powerful tool for the synthesis of multi-strand anion helicates.

    4. Heterocycle Synthesis

      Selective Oxytrifluoromethylation of Allylamines with CO2

      Jian-Heng Ye, Lei Song, Prof. Dr. Wen-Jun Zhou, Tao Ju, Zhu-Bao Yin, Si-Shun Yan, Zhen Zhang, Dr. Jing Li and Prof. Dr. Da-Gang Yu

      Version of Record online: 14 JUL 2016 | DOI: 10.1002/anie.201603352

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      CO2 changes things: The title reaction leads to important 2-oxazolidones. CO2 plays a vital role in tuning the difunctionalization of alkenes from amino- to oxytrifluoromethylation. This reaction is highly chemo-, regio-, and diastereoselective under redox-neutral and mild reaction conditions. Moreover, these reactions feature good functional-group tolerance, broad substrate scope, and easy scalability.

    5. Perovskite Oxides

      Subsurface Space-Charge Dopant Segregation to Compensate Surface Excess Charge in a Perovskite Oxide

      Prof. Sung-Yoon Chung, Dr. Si-Young Choi, Hye-In Yoon, Hye-Sung Kim and Hyung Bin Bae

      Version of Record online: 14 JUL 2016 | DOI: 10.1002/anie.201605561

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      Below the surface: Space-charge-driven dopant segregation in the subsurface region of an oxide, rather than the surface itself, is directly visualized with atomic resolution by transmission electron microscopy. A combination of atomic column resolved images and chemical analyses clarify the position of segregation.

  20. Cover Pictures

    1. You have free access to this content
      Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization

      Thibault Viennet, Dr. Aldino Viegas, Arne Kuepper, Sabine Arens, Prof. Dr. Vladimir Gelev, Prof. Dr. Ognyan Petrov, Prof. Dr. Tom N. Grossmann, Prof. Dr. Henrike Heise and Dr. Manuel Etzkorn

      Version of Record online: 14 JUL 2016 | DOI: 10.1002/anie.201606093

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      Directing hyperpolarization to a target protein makes it possible to selectively filter out signals of specific proteins from a large background. In their Communication (DOI: 10.1002/anie.201603205), M. Etzkorn et al. show that dynamic nuclear polarization can be directed to a target protein by using a biradical-labeled ligand. The resulting reduction of the background facilitates solid-state NMR studies of the target protein in increasingly native environments.

  21. Communications

    1. Photothermal Therapy | Very Important Paper

      Controlling Spatial Heat and Light Distribution by Using Photothermal Enhancing Auto-Regulated Liposomes (PEARLs)

      Dr. Kenneth K. Ng, Dr. Robert A. Weersink, Dr. Liang Lim, Prof. Brian C. Wilson and Prof. Gang Zheng

      Version of Record online: 14 JUL 2016 | DOI: 10.1002/anie.201605241

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      Evenly heated: Photothermal J-aggregate nanoparticles based on photothermal enhancing auto-regulating liposomes (PEARLs), have a closed-loop thermal feedback capability. This feedback mechanism enables an iterative increase in light transmission to achieve deeper and more homogeneous heating during photothermal therapy.

  22. Reviews

    1. C−H Activation

      C−H Coupling Reactions Directed by Sulfoxides: Teaching an Old Functional Group New Tricks

      Dr. Alexander P. Pulis and Prof. David J. Procter

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201601540

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      Classical sulfoxide directing groups have been given a new lease on life because of their unique ability to direct a variety of C−H couplings to form important C−C bonds. Sulfoxide direction operates through internal coordination to a metal (directing groups), through external coordination (ligands), or via sulfoxide capture of nucleophilic or electrophilic coupling partners (sulfonium-directed).

  23. Minireviews

    1. Supramolecular Chemistry

      Porous Organic Molecular Frameworks with Extrinsic Porosity: Platform for Carbon Storage and Separation

      Dr. Jian Lü and Prof. Dr. Rong Cao

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201602116

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      Porous organic molecular frameworks (POMFs) have recently been discovered as a new class of chemical materials for carbon storage and separation. The assembly of POMFs by means of primary hydrogen bonding interactions is reviewed based on their applications in both the solid state and solution phase.

  24. Communications

    1. Surface Reactions

      On-Surface Domino Reactions: Glaser Coupling and Dehydrogenative Coupling of a Biscarboxylic Acid To Form Polymeric Bisacylperoxides

      Philipp Alexander Held, Dr. Hong-Ying Gao, Lacheng Liu, Dr. Christian Mück-Lichtenfeld, Alexander Timmer, Dr. Harry Mönig, Dennis Barton, Prof. Dr. Johannes Neugebauer, Prof. Dr. Harald Fuchs and Prof. Dr. Armido Studer

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201602859

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      Playing dominos on gold: 6-Ethynyl-2-naphthoic acid (ENA) undergoes on-surface Glaser coupling on gold to form 6,6′-(1,4-buta-1,3-diynyl)bis(2-naphthoic acid) (BDNA) which in turn reacts in an unprecedented dehydrogenative coupling of the acid functionalities to give poly-BDNA. Polymeric chains with a length of over 100 nm can be obtained and the reaction outcome is influenced by the Au-surface topography and the surface coverage.

    2. Synthetic Methods

      Zirconocene-Mediated Carbonylative Coupling of Grignard Reagents

      Melissa Moss, Xinping Han and Prof. Joseph M. Ready

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201603133

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      An inclusive approach: Acyl zirconocenes [Cp2ZrCl(COR)] are valuable acyl anion equivalents in synthetic chemistry. Traditionally, they have been prepared by the hydrozirconation of alkenes or alkynes, thus precluding the generation of aryl, benzyl, tertiary alkyl, or branched acyl zirconocenes. Now a zirconium-mediated carbonylative coupling of Grignard reagents is described that involves previously inaccessible zirconocene intermediates (see scheme).

    3. Enzyme Modifications

      You have full text access to this OnlineOpen article
      Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short-Chain Dehydrogenases/Reductases

      Antonios Lygidakis, Dr. Vijaykumar Karuppiah, Dr. Robin Hoeven, Dr. Aisling Ní Cheallaigh, Prof. David Leys, Dr. John M. Gardiner, Dr. Helen S. Toogood and Prof. Nigel S. Scrutton

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201603785

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      A simple mechanistic switch: The replacement of tyrosine by glutamic acid in (−)-menthone:(+)-neomenthol reductase and of glutamic acid by tyrosine in isopiperitenone reductase enabled a switch between ene-reductase and ketoreduction activity in the short-chain dehydrogenases/reductases superfamily. This provides attractive routes to novel ene-reductase catalysts.

    4. Rechargeable Lithium Batteries | Hot Paper

      Organotrisulfide: A High Capacity Cathode Material for Rechargeable Lithium Batteries

      Min Wu, Yi Cui, Amruth Bhargav, Yaroslav Losovyj, Amanda Siegel, Mangilal Agarwal, Ying Ma and Yongzhu Fu

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201603897

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      SSSsuitable for batteries: Dimethyl trisulfide (DMTS) was used as a model compound to demonstrate that organotrisulfide compounds can be high capacity cathode materials undergoing multi-electron redox reactions for rechargeable lithium batteries. The lithium/DMTS cell has a high specific energy density of 229 Wh kg−1 as a result of low electrolyte/DMTS ratios.

    5. Weakly Coordinating Anions

      Coordination Chemistry of Diiodine and Implications for the Oxidation Capacity of the Synergistic Ag+/X2 (X=Cl, Br, I) System

      Dr. Przemysław J. Malinowski, Dr. Daniel Himmel and Prof. Dr. Ingo Krossing

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201603913

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      Coordination chemistry of diiodine: Silver(I) ions and diiodine molecules are an unexpectedly variable couple that form dication salts with up to six diiodine molecules as well as the molecule AAg-I2-AgA (A=[Al(ORf)4], Rf=C(CF3)3). This molecule presents an easily in bulk accessible strong oxidizer converting pentane and propane to carbocations, and white phosphorus to P9+.

    6. Iron(II) Complexes

      Divergent Coordination Chemistry: Parallel Synthesis of [2×2] Iron(II) Grid-Complex Tauto-Conformers

      Dr. Bernhard Schäfer, Dr. Jean-François Greisch, Dr. Isabelle Faus, Dr. Tilmann Bodenstein, Dr. Ivan Šalitroš, Dr. Olaf Fuhr, Priv.-Doz. Dr. Karin Fink, Prof. Dr. Volker Schünemann, Prof. Dr. Manfred M. Kappes and Prof. Dr. Mario Ruben

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201603916

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      The coordination of FeII metal ions by a homoditopic ligand L with two tridentate chelates leads to the tautomerism-driven emergence of complexity. The two tauto-isomeric FeII4L4 tetramers that were thus formed exhibit different magnetic properties. One complex undergoes spin crossover (SCO), whereas the other one is blocked in the FeII high spin (HS) state.

    7. Dinitrogen Complexes | Hot Paper

      A Dinitrogen Dicopper(I) Complex via a Mixed-Valence Dicopper Hydride

      Shiyu Zhang, Hengameh Fallah, Evan J. Gardner, Dr. Subrata Kundu, Dr. Jeffery A. Bertke, Prof. Thomas R. Cundari and Prof. Timothy H. Warren

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201603970

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      Caught between two coppers: A tris(pyrazolyl)borate (Tp) dicopper N2 complex [CuI]2(μ-N2) forms through the intermediacy of a mixed-valence dicopper hydride [Cu1⋅5]2(μ-H). Besides allowing a direct comparison between N2 and O2 binding at copper(I), this [CuI]2(μ-N2) complex represents a key member in a family of TpCu complexes [CuI]2(μ-NH=NH) and [CuI](NH2NH2) featuring reduced N2 ligands.

    8. Rearrangements

      Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines

      Dr. Toni Moragas, Ryan M. Liffey, Dr. Dominika Regentová, Jon-Paul S. Ward, Justine Dutton, Dr. William Lewis, Prof. Ian Churcher, Dr. Lesley Walton, Dr. José A. Souto and Prof. Robert A. Stockman

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201604188

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      Making and breaking rings: A novel rearrangement of 2-vinyl aziridine 2-carboxylates to unusual chiral cyclic sulfoximines is described. The method allows the synthesis of substituted cyclic sulfoximines in high yields with complete stereocontrol, and tolerates a wide substrate scope. A one-pot process starting directly from sulfinimines provides access to complex chiral sulfoximines in only two steps from commercially available aldehydes.

    9. Polymer Colloids

      Stimuli-Responsive Shape Switching of Polymer Colloids by Temperature-Sensitive Absorption of Solvent

      Dr. Huaguang Wang, Binghui Li, Prof. Arjun G. Yodh and Prof. Zexin Zhang

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201604294

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      Turning up the heat on colloid particles: The shape of polymer colloidal particles can be switched in a temperature-dependent controllable manner from non-spherical to spherical in a water/2,6-lutidine binary mixture.

    10. Computational Chemistry

      Structural Interpretation of Metastable States in Myoglobin–NO

      Dr. Maksym Soloviov, Akshaya K. Das and Prof. Markus Meuwly

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201604552

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      Reactive molecular dynamics simulations find two timescales for nitric oxide rebinding to myoglobin. These two timescales were assigned to the structures “A” and “B” of the His64 side chain, which controls ligand access to the heme iron center.

    11. DNA Nanotechnology | Hot Paper

      Designer Extracellular Matrix Based on DNA–Peptide Networks Generated by Polymerase Chain Reaction

      Alexander Finke, Dr. Holger Bußkamp, Dr. Marilena Manea and Prof. Dr. Andreas Marx

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/anie.201604687

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      Catch and release: A functional DNA-based network was generated by PCR and functionalized with a peptide that specifically interacts with certain cell types while others are repelled. By following this approach, specific cell types were attracted to functionalized surfaces. The cells remained viable and could also be easily detached for future studies.

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