N-linked Glycans of Chloroviruses Sharing a Core Architecture without Precedent
Prof. Cristina De Castro, Dr. Immacolata Speciale, Prof. Garry Duncan, Dr. David D. Dunigan, Dr. Irina Agarkova, Prof. Rosa Lanzetta, Dr. Luisa Sturiale, Dr. Angelo Palmigiano, Prof. Domenico Garozzo, Prof. Antonio Molinaro, Prof. Michela Tonetti and Prof. James L. Van Etten
Article first published online: 19 NOV 2015 | DOI: 10.1002/anie.201509150
Glycan signature: Chloroviruses glycosylate their capsid protein in a host-independent process. These N-linked glycans have unprecedented structures, and each is virus-specific, but all share the same core motif. Conservation in the core region occurs at two different levels: the most conserved region comprises five residues and inclusion of the sixth extends this strictly conserved core. This core oligosaccharide represents a new type of N-glycosylation.