Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure–Activity Relationships
Dr. Silke C. Wenzel, Dr. Holger Hoffmann, Dr. Jidong Zhang, Dr. Laurent Debussche, Dr. Sabine Haag-Richter, Dr. Michael Kurz, Dr. Frederico Nardi, Dr. Peer Lukat, Irene Kochems, Dr. Heiko Tietgen, Prof. Dr. Dietmar Schummer, Jean-Paul Nicolas, Dr. Loreley Calvet, Dr. Valerie Czepczor, Dr. Patricia Vrignaud, Dr. Agnes Mühlenweg, Priv.-Doz. Dr. Stefan Pelzer, Prof. Dr. Rolf Müller and Prof. Dr. Mark Brönstrup
Article first published online: 30 OCT 2015 | DOI: 10.1002/anie.201508277
A terrestrial dive to bengamides: Bengamides, sponge-derived natural products, have been generated from a terrestrial source. Their biosynthesis and self-resistance mechanism against methionine aminopeptidases was elucidated, a heterologous expression platform was established, and their pharmaceutical properties were improved by medicinal chemistry.