Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 37

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Upcoming Hot Papers

Hot Papers are chosen by the Editors for their importance in a rapidly evolving field of high current interest. Many of the "Very Important Papers" (VIPs) would certainly qualify to be included here, but such a duplication is avoided.

Antibiotics

An Accurate In Vitro Model of the E. coli Envelope

Dr. Luke A. Clifton, Dr. Stephen A. Holt, Dr. Arwel V. Hughes, Dr. Emma L. Daulton, Dr. Wanatchaporn Arunmanee, Dr. Frank Heinrich, Dr. Syma Khalid, Damien Jefferies, Dr. Timothy R. Charlton, Dr. John R. P. Webster, Dr. Christian J. Kinane and Prof. Jeremy H. Lakey

An Accurate In Vitro Model of the E. coli EnvelopeUnderstanding the outer membranes of Gram-negative bacteria is important for the development of new antibacterial compounds. However, their structure and dynamics are poorly understood because of their small in vivo size and inaccurate in vitro models. A stable asymmetric model of the outer membrane that can be analyzed by a range of biophysical techniques and accurately imitates the in vivo behavior of natural outer membranes is herein presented.

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Drug Delivery

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing

Wujin Sun, Wenyan Ji, Jordan M. Hall, Quanyin Hu, Dr. Chao Wang, Prof. Dr. Chase L. Beisel and Prof. Dr. Zhen Gu

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome EditingAll rolled into one: A biologically inspired delivery vehicle for CRISPR–Cas9 is based on yarn-like DNA nanoparticles that are synthesized by rolling circle amplification. The DNA nanoclews were efficiently loaded with Cas9 protein/single guide RNA complexes and delivered them into human cells, enabling targeted gene disruption.

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Mesoporous Materials

Periodic Mesoporous Organosilica with Molecular-Scale Ordering Self-Assembled by Hydrogen Bonds

Dr. Norihiro Mizoshita and Dr. Shinji Inagaki

Periodic Mesoporous Organosilica with Molecular-Scale Ordering Self-Assembled by Hydrogen BondsHost–guest systems: Self-assembly of an organosilane precursor by hydrogen bonding is the key to construction of a new class of crystal-like periodic mesoporous organosilicas (see picture). The present mesoporous materials can stably accomodate silane-free H-bonding guest molecules within the pore walls, which is applicable to non-covalent modification of organosilica hybrids.

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Viruses

Whole-Genome Sequencing of a Single Viral Species from a Highly Heterogeneous Sample

Dr. Hee-Sun Han, Paul G. Cantalupo, Dr. Assaf Rotem, Dr. Shelley K. Cockrell, Martial Carbonnaux, Prof. James M. Pipas and Prof. David A. Weitz

Whole-Genome Sequencing of a Single Viral Species from a Highly Heterogeneous SampleOn a drop-in basis: A new platform that integrates drop-based microfluidics and computational analysis was developed for purification of a single viral species from a mixed sample and retrieval of its complete genome sequence. This method was used to retrieve the genome sequence of SV40 spiked into wastewater with more than 96 % sequence coverage and 99.8 % sequence identity. The platform can also be used to detect and identify unknown viruses.

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Electrocatalysis

Stability of Fe-N-C Catalysts in Acidic Medium Studied by Operando Spectroscopy

Dr. Chang Hyuck Choi, Claudio Baldizzone, Jan-Philipp Grote, Dr. Anna K. Schuppert, Dr. Frédéric Jaouen and Dr. Karl J. J. Mayrhofer

Stability of Fe-N-C Catalysts in Acidic Medium Studied by Operando SpectroscopyThe stable potential window of Fe-N-C catalysts for oxygen reduction reactions is studied using a scanning flow cell equipped with advanced online analytical techniques. Fe demetalation and carbon oxidation (see picture) are observed in low (<0.7 V) and high (>0.9 V) potential regions, respectively, which can introduce significant performance drops in a fuel cell.

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Drug Delivery

Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein–Drug Conjugates for Targeted Therapy

Dr. Joong-jae Lee, Hyo-Jung Choi, Misun Yun, YingJin Kang, Ji-Eun Jung, Dr. Yiseul Ryu, Tae Yoon Kim, Young-je Cha, Prof. Hyun-Soo Cho, Prof. Jung-Joon Min, Dr. Chul-Woong Chung and Prof. Hak-Sung Kim

Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein–Drug Conjugates for Targeted TherapyA chemoenzymatic conjugation method that is based on enzymatic prenylation and oxime ligation is a simple and efficient means for generating highly stable and homogeneous protein–drug conjugates in a site-specific manner. It can be generally applied to the conjugation of drugs to a wide range of protein binders, facilitating the development of targeted therapies with high efficacies and low off-target effects.

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Strontium guanidinate

Synthesis, Structure, and Properties of SrC(NH)3, a Nitrogen-Based Carbonate Analogue with the Trinacria Motif

M. Sc. Ronja Missong, M. Sc. Janine George, Dr. Andreas Houben, Dr. Markus Hoelzel and Prof. Dr. Richard Dronskowski

Synthesis, Structure, and Properties of SrC(NH)3, a Nitrogen-Based Carbonate Analogue with the Trinacria MotifKeeping an ion guanidinate: Strontium guanidinate, SrC(NH)3, the first compound with a doubly deprotonated guanidine unit, was synthesized, and its properties investigated using X-ray and neutron powder diffraction as well as IR spectroscopy. Combined with quantum-theoretical calculations, allows a qualitative and quantitative discussion some first insights into the structure of the anionic guanidine unit.

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Biosensors

Site-Directed, On-Surface Assembly of DNA Nanostructures

Dr. Rebecca Meyer, Dr. Barbara Saccà and Prof. Dr. Christof M. Niemeyer

Site-Directed, On-Surface Assembly of DNA NanostructuresFrom micro to nano: Orthogonal topographic modification of planar DNA nanostructures combined with site-directed on-surface assembly provides a means to bridge top-down micropatterning with bottom-up nanotechnology.

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Nanostructures

Large-Area, Free-Standing, Two-Dimensional Supramolecular Polymer Single-Layer Sheet for Highly Efficient Electrocatalytic Hydrogen Evolution

Dr. Renhao Dong, Martin Pfeffermann, Dr. Haiwei Liang, Dr. Zhikun Zheng, Dr. Xiang Zhu, Dr. Jian Zhang and Prof. Dr. Xinliang Feng

Large-Area, Free-Standing, Two-Dimensional Supramolecular Polymer Single-Layer Sheet for Highly Efficient Electrocatalytic Hydrogen EvolutionStanding up: The Langmuir–Blodgett method can be used to prepare two-dimensional supramolecular polymer (2DSP) sheets from nickel bis(dithiolene) complexes at the air–water interface (see figure). These free-standing single-layer sheets, which are 0.7–0.9 nm thick and square millimeters in area, showed excellent electrocatalytic activities in the hydrogen evolution reaction from water.

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Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis Catalysts

Liang Liang, Dr. Hao Cheng, Fengcai Lei, Dr. Jun Han, Shan Gao, Dr. Chengming Wang, Prof. Yongfu Sun, Shaista Qamar, Prof. Shiqiang Wei and Prof. Yi Xie

Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis CatalystsSingle-unit-cell orthorhombic CoSe2 sheets are prepared by thermally exfoliating a lamellar CoSe2-DETA hybrid. As shown by Y. Xie, Y. F. Sun et al. in their Communication (10.1002/anie.201505245) the single-unit-cell thickness means that 66.7 % of the Co2+ ions are exposed on the surface and are low coordinate (coordination numbers of 1.3 and 2.6) leading to a lower Tafel slope (64 mV dec−1) and higher turnover frequency (745 h−1) in water splitting.

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Structure-Directing Agents

Synthesis of Silicate Zeolite Analogues Using Organic Sulfonium Compounds as Structure-Directing Agents

Dr. Changbum Jo, Sungjune Lee, Prof. Sung June Cho and Prof. Ryong Ryoo

Synthesis of Silicate Zeolite Analogues Using Organic Sulfonium Compounds as Structure-Directing AgentsA zeolite with MEL structure and three other germanosilicate zeolites were synthesized using organic sulfonium compounds as structure-directing agents. Depending on the synthesis conditions, the germanosilicates had ISV, ITT, or a new zeolite structure. The new germanosilicate exhibited two types of accessible micropores with diameters of 0.61 and 0.78 nm after calcination.

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Photothermal Agents

Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents

Dr. Zhengbo Sun, Hanhan Xie, Siying Tang, Prof. Xue-Feng Yu, Zhinan Guo, Jundong Shao, Prof. Han Zhang, Hao Huang, Prof. Huaiyu Wang and Prof. Paul K. Chu

Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal AgentsA liquid exfoliation method based on a combination of probe sonication and bath sonication was adopted to synthesize black phosphorus quantum dots (BPQDs). These displayed a high extinction coefficient of 14.8 Lg−1 cm−1, a photothermal conversion efficiency of 28.4 %, and good biocompatibility, and can thus be used as highly effective photothermal agents for cancer therapy.

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Structural Virology

Attachment of Norovirus to Histo Blood Group Antigens: A Cooperative Multistep Process

Dr. Alvaro Mallagaray, Julia Lockhauserbäumer, Dr. Grant Hansman, Dr. Charlotte Uetrecht and Prof. Dr. Thomas Peters

Attachment of Norovirus to Histo Blood Group Antigens: A Cooperative Multistep ProcessMore than binding: Attachment of noroviruses to histo blood group antigens is a complex and cooperative process. This is in contrast to current perception conveying simple one-site binding. NMR spectroscopy and native mass spectrometry independently confirm this new paradigm of virus–carbohydrate interaction.

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Synthetic Methods

Aqueous Titanium Trichloride-Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine

Dr. Shuo Tong, Dr. Zhengren Xu, Mathias Mamboury, Dr. Qian Wang and Prof. Dr. Jieping Zhu

Aqueous Titanium Trichloride-Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and AspidospermidineMild and efficient treatment of o-nitrostyrenes with aqueous TiCl3 solution at room temperature afforded indoles through a formal reductive C(sp2)–H amination process. A concise synthesis of a marketed drug (rizatriptan) and a formal total synthesis of aspidospermidine featuring this novel N-heterocyclization process are reported.

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Nanorods

A Unique Ternary Semiconductor–(Semiconductor/Metal) Nano-Architecture for Efficient Photocatalytic Hydrogen Evolution

Tao-Tao Zhuang, Yan Liu, Meng Sun, Shen-Long Jiang, Ming-Wen Zhang, Prof. Dr. Xin-Chen Wang, Prof. Dr. Qun Zhang, Prof. Dr. Jun Jiang and Prof. Dr. Shu-Hong Yu

A Unique Ternary Semiconductor–(Semiconductor/Metal) Nano-Architecture for Efficient Photocatalytic Hydrogen EvolutionThree in one: A unique 1D ternary hetero-nanorod (ZnS) with segmented node sheaths (CdS) decorated by metal nanoparticles (Au) is constructed by a sequential chemical-transformation strategy. The arrangement enables steered charge flow for electron–hole separation and hence efficient photocatalysis.

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CO2 Activation

Hydrophosphination of CO2 and Subsequent Formate Transfer in the 1,3,2-Diazaphospholene-Catalyzed N-Formylation of Amines

Che Chang Chong and Prof. Dr. Rei Kinjo

Hydrophosphination of CO2 and Subsequent Formate Transfer in the 1,3,2-Diazaphospholene-Catalyzed N-Formylation of AminesFormate formation: Hydrophosphination of CO2 with 2-H-1,3,2-Diazaphospholene afforded phosphorus formate, from which transfer of the formate to Ph2SiH2 produced Ph2Si(OCHO)2. These elementary reactions were applied to the metal-free catalytic N-formylation of various amine derivatives with CO2 in a one-pot approach at room temperature.

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Carbon Nanotubes

Template Synthesis of Linear-Chain Nanodiamonds Inside Carbon Nanotubes from Bridgehead-Halogenated Diamantane Precursors

Yusuke Nakanishi, Dr. Haruka Omachi, Dr. Natalie A. Fokina, Prof. Dr. Peter R. Schreiner, Prof. Dr. Ryo Kitaura, Dr. Jeremy E. P. Dahl, Prof. Dr. Robert M. K. Carlson and Prof. Dr. Hisanori Shinohara

Template Synthesis of Linear-Chain Nanodiamonds Inside Carbon Nanotubes from Bridgehead-Halogenated Diamantane PrecursorsLong diamonds: A simple method for the synthesis of linear-chain diamond-like nanomaterials, so-called diamantane polymers, is described. This synthetic approach is primarily based on a template reaction of dihalogen-substituted diamantane precursors in the hollow cavities of carbon nanotubes. The present strategy may be used for the design and synthesis of other one-dimensional nanomaterials.

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Luminescent Complexes

[Cr(ddpd)2]3+: A Molecular, Water-Soluble, Highly NIR-Emissive Ruby Analogue

Sven Otto, Dr. Markus Grabolle, Dr. Christoph Förster, Christoph Kreitner, Dr. Ute Resch-Genger and Prof. Katja Heinze

[Cr(ddpd)2]3+: A Molecular, Water-Soluble, Highly NIR-Emissive Ruby AnalogueStrong, long-lived, and sharp NIR phosphorescence (775 nm, Φ=12 %, τ=899 μs) is achieved in the soluble chromium(III) complex [Cr(ddpd)2]3+ (ddpd=N,N′-dimethyl-N,N′-dipyridin-2-ylpyridine-2,6-diamine) by ligand-field tuning through optimization of the ligand’s bite angle and σ-donor strength. 3O2 quenches the emission allowing for optical oxygen sensing. The highly stable complex is easy to prepare in high yields from inexpensive starting materials.

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Mesoporous Metals

Polymeric Micelle Assembly for the Smart Synthesis of Mesoporous Platinum Nanospheres with Tunable Pore Sizes

Yunqi Li, Dr. Bishnu Prasad Bastakoti, Dr. Victor Malgras, Dr. Cuiling Li, Jing Tang, Prof. Jung Ho Kim and Prof. Yusuke Yamauchi

Polymeric Micelle Assembly for the Smart Synthesis of Mesoporous Platinum Nanospheres with Tunable Pore SizesA polymeric micelle assembly is used for the fabrication of well-dispersed mesoporous Pt nanospheres. A core–shell–corona triblock copolymer [poly(styrene-b-2-vinylpyridine-b-ethylene oxide), PS-b-P2VP-b-PEO] is employed as the pore-directing agent. The negatively charged PtCl42− ions preferably interact with the protonated P2VP+ blocks while the free PEO chains prevent the aggregation of the Pt nanospheres.

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Wearable Electronics

Realizing both High Energy and High Power Densities by Twisting Three Carbon-Nanotube-Based Hybrid Fibers

Ye Zhang, Yang Zhao, Dr. Xunliang Cheng, Dr. Wei Weng, Jing Ren, Xin Fang, Yishu Jiang, Peining Chen, Zhitao Zhang, Prof. Yonggang Wang and Prof. Huisheng Peng

Realizing both High Energy and High Power Densities by Twisting Three Carbon-Nanotube-Based Hybrid FibersStrand and deliver: A fiber-shaped hybrid energy-storage device is created by twisting three different carbon nanotube hybrid fibers together to integrate the properties of a lithium-ion battery and a supercapacitor. The twisted strands giving rise to both high energy and power densities. The hybrid device is three-dimensionally flexible, weaveable, and wearable, which offers promising advantages in the modern electronics.

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Electrocatalysis

Electrocatalytic Hydrogen Production by an Aluminum(III) Complex: Ligand-Based Proton and Electron Transfer

Emily J. Thompson and Prof. Louise A. Berben

Electrocatalytic Hydrogen Production by an Aluminum(III) Complex: Ligand-Based Proton and Electron TransferTwo in one: Proton and electron transfer by a complex comprising Al3+ and a redox-active iminopyridine ligand promotes electrocatalytic H2 evolution. The Al3+ center brings the reduction potential of the ligand into an accessible range for low-overpotential proton production. The proposed mechanism involves two protonation events at the ligand and a subsequent two-electron reduction to liberate hydrogen (see figure).

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Pyrotechnics

Chlorine-Free Red-Burning Pyrotechnics

Dr. Jesse J. Sabatini, Dr. Ernst-Christian Koch, Dr. Jay C. Poret, Dr. Jared D. Moretti and Seth M. Harbol

Chlorine-Free Red-Burning PyrotechnicsSeeing red: The emission from SrOH(g) alone is responsible for the red color of a chlorine-free high-intensity flare based on magnesium, strontium nitrate, 5-amino-1H-tetrazole or hexamine, and Epon binder. The detrimental orange emission from SrO(g) could be successfully suppressed. The new formulations avoid any risk of forming carcinogenic polychlorinated aromatic compounds and will positively impact civilian and military pyrotechnics.

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Photothermal Effects

Thermosensitive Ion Channel Activation in Single Neuronal Cells by Using Surface-Engineered Plasmonic Nanoparticles

Hirotaka Nakatsuji, Dr. Tomohiro Numata, Dr. Nobuhiro Morone, Prof. Shuji Kaneko, Prof. Yasuo Mori, Prof. Hiroshi Imahori and Dr. Tatsuya Murakami

Thermosensitive Ion Channel Activation in Single Neuronal Cells by Using Surface-Engineered Plasmonic NanoparticlesHot membranes: A non-disruptive plasma membrane heating method employs gold nanorods (AuNRs) coated with a cationic protein/lipid complex. Under near-infrared illumination, these AuNRs induce highly localized photothermal heat generation in intact neuronal cells without membrane damage, enabling Ca2+ influx solely by activation of the thermosensitive cation channel TRPV1.

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Key Intermediates

The Methylsulfonyloxyl Radical, CH3SO3

Bifeng Zhu, Prof. Dr. Xiaoqing Zeng, Dr. Helmut Beckers, Prof. Dr. Joseph S. Francisco and Prof. Dr. Helge Willner

The Methylsulfonyloxyl Radical, CH3SO3Up in the air: Low-pressure flash pyrolysis of CH3SO2OOSO2CH3 has been used to generate the methylsulfonyloxyl radical (CH3SO3), one of the key intermediates in the atmospheric oxidation of dimethyl sulfide, which was subsequently isolated in solid noble-gas matrices. The radical has been characterized by UV/Vis and IR spectroscopy and its photoinduced (λ≥360 nm) tautomerization to CH2SO3H was observed.

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Polymerization

Regioregular Synthesis of Azaborine Oligomers and a Polymer with a syn Conformation Stabilized by N[BOND]H⋅⋅⋅π Interactions

Andrew W. Baggett, Fang Guo, Dr. Bo Li, Prof. Dr. Shih-Yuan Liu and Prof. Dr. Frieder Jäkle

Regioregular Synthesis of Azaborine Oligomers and a Polymer with a syn Conformation Stabilized by N<img src="http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif" alt="[BOND]" />H⋅⋅⋅π InteractionsA BN serial: A regioregular conjugated polymer and short model oligomers constructed solely from 1,2-azaborine units by Suzuki–Miyaura cross-coupling have been synthesized and found to adopt an unusual syn conformation stabilized by N[BOND]H⋅⋅⋅π interactions. The optoelectronic properties of the polymer more closely resemble the computationally predicted properties of poly(cyclohexadiene) rather than those of poly(p-phenylene). pin=pinacol.

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Fluorescence Imaging

Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry

Paresh Agarwal, Brendan J. Beahm, Peyton Shieh and Prof. Carolyn R. Bertozzi

Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal ChemistryHow exSiating! Systemic fluorescence imaging of cell-surface glycans inside a live animal is described for the first time. Metabolic incorporation of a cyclooctyne-functionalized sialic acid into glycans during zebrafish embryogenesis followed by ligation with a fluorogenic tetrazine enables the visualization of sialoglycoconjugates.

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CO Homologues

{μ-PbSe}: A Heavy CO Homologue as an Unexpected Ligand

Dr. Günther Thiele, Yannick Franzke, Priv.-Doz. Dr. Florian Weigend and Prof. Dr. Stefanie Dehnen

{μ-PbSe}: A Heavy CO Homologue as an Unexpected LigandLike a mosquito's stinger, the second heaviest CO homologue, μ-PbSe, is attached with a distinct bent coordination mode to an Rh3Se2 cluster moiety. The ionic compound comprising the [Rh3(CN)2(PPh3)43-Se)2(μ-PbSe)]3− anion (shown) was obtained as a side product along with a larger Rh/Se cluster, and apparently arises from an unbridged species that crystallizes under slightly different reaction conditions. Experimental and quantum chemical analyses explain the nature of this uncommon ligand.

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Cycloaddition

Pentafulvene for the Synthesis of Complex Natural Products: Total Syntheses of (±)-Pallambins A and B

Christian Ebner and Prof. Dr. Erick M. Carreira

Pentafulvene for the Synthesis of Complex Natural Products: Total Syntheses of (±)-Pallambins A and BCore congestion: The first total syntheses of the diterpenoids (±)-pallambins A and B are reported. The use of fulvene in a Diels–Alder cycloaddition is without precedence in complex synthesis and enables, in combination with a strategic C[BOND]H insertion, rapid assembly of the tetracyclo[4.4.03,5.02,8]decane core.

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Hydrogen Trioxide

A Simple and Efficient Preparation of High-Purity Hydrogen Trioxide (HOOOH)

Gregor Strle and Prof. Dr. Janez Cerkovnik

A Simple and Efficient Preparation of High-Purity Hydrogen Trioxide (HOOOH)O3 can do: Hydrogen trioxide (HOOOH) is prepared on functionalized polymer beads and subsequently released. Solutions of high-purity HOOOH in diethyl ether, free of any reactants and by-products, may be stored at −20 °C for weeks. HOOOH could be also isolated in highly pure form or dissolved in another solvent, thus significantly extending the research perspectives of HOOOH.

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Water Splitting

Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis Catalysts

Liang Liang, Dr. Hao Cheng, Fengcai Lei, Dr. Jun Han, Shan Gao, Dr. Chengming Wang, Prof. Yongfu Sun, Shaista Qamar, Prof. Shiqiang Wei and Prof. Yi Xie

Metallic Single-Unit-Cell Orthorhombic Cobalt Diselenide Atomic Layers: Robust Water-Electrolysis CatalystsThe shape of thins to come: Atomic layers bring better catalytic properties as shown by thermally exfoliating a lamellar CoSe2-DETA hybrid to give single-unit-cell orthorhombic CoSe2 sheets. The single-unit-cell thickness means that 66.7 % of the Co2+ ions are exposed on the surface and are low coordinate leading to a lower Tafel slope and higher turnover frequency in water splitting.

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Origin of Life

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides

Dr. Neha P. Kamat, Dr. Sylvia Tobé, Ian T. Hill and Prof. Jack W. Szostak

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic PeptidesRNA–membrane association: Simple peptides (as small as three amino acids) can localize RNA to model membrane systems by electrostatic interactions. Microscopy studies showed that peptides can cross vesicle membranes to localize encapsulated RNA.

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Soft Matter

Multi-Compartmental Hydrogel Microparticles Fabricated by Combination of Sequential Electrospinning and Photopatterning

Kanghee Cho, Hyun Jong Lee, San Won Han, Ji Hong Min, Prof. Hansoo Park and Prof. Won-Gun Koh

Multi-Compartmental Hydrogel Microparticles Fabricated by Combination of Sequential Electrospinning and PhotopatterningMulti-compartmental hydrogel microparticles were fabricated by combining electrospinning and photopatterning processes. Each compartment was made of a fiber matrix with different composition. the resultant microparticles have a potential for various biomedical applications such as bioassay, drug delivery, and tissue engineering.

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Carbohydrate Immunology

Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide of Streptococcus pneumoniae Serotype 4

Dr. Claney L. Pereira, Andreas Geissner, Dr. Chakkumkal Anish and Prof. Dr. Peter H. Seeberger

Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide of Streptococcus pneumoniae Serotype 4Unusually Protective. In the search for a glycan epitope for protection against Streptococcus pneumoniae serotype 4, total synthesis of the repeating unit (see structure) enabled the identification of pyruvate as a crucial determinant of immunogenicity. This lays the foundation for the development of a new antibacterial vaccine candidate against Streptococcus pneumoniae serotype 4.

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Light-Emitting Diodes

Waterproof Alkyl Phosphate Coated Fluoride Phosphors for Optoelectronic Materials

Dr. Hoang-Duy Nguyen, Dr. Chun Che Lin and Prof. Dr. Ru-Shi Liu

Waterproof Alkyl Phosphate Coated Fluoride Phosphors for Optoelectronic MaterialsThe moisture instability of fluoride phosphors has limited their application in optoelectronic devices. Their waterproof properties can be improved by a hydrophobic coating layer, such as an alkyl phosphate. The luminous efficacy of warm white-light-emitting diodes (WLEDs) based on such coated phosphors is remarkably stable even under high-humidity and high-temperature conditions.

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Perovskites

Rattling in the Quadruple Perovskite CuCu3V4O12

Dr. Yasuhide Akizuki, Dr. Ikuya Yamada, Dr. Koji Fujita, Kazuya Taga, Dr. Takateru Kawakami, Dr. Masaichiro Mizumaki and Prof. Katsuhisa Tanaka

Rattling in the Quadruple Perovskite CuCu3V4O12Oversize me: CuCu3V4O12 is synthesized using a high-pressure technique. This compound adopts the cubic A-site ordered perovskite-type structure (space group Imequation image) with a valence distribution of Cu2+Cu2+3V4+4O12. It has oversized icosahedral cages in which loosely bound A-site Cu2+ ions rattle with a characteristic temperature (Einstein temperature) of ΘE≈55 K. This is the first demonstration of rattling in perovskites.

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Organic Reductants

Pushing the Limits of Neutral Organic Electron Donors: A Tetra(iminophosphorano)-Substituted Bispyridinylidene

Samuel S. Hanson, Dr. Eswararao Doni, Kyle T. Traboulsee, Dr. Graeme Coulthard, Prof. Dr. John A. Murphy and Prof. Dr. C. Adam Dyker

Pushing the Limits of Neutral Organic Electron Donors: A Tetra(iminophosphorano)-Substituted BispyridinylideneUnlocking max potential: The four strongly π-donating iminophosphorano substituents of compound 1 impart an impressive redox potential of −1.70 V versus saturated calomel electrode (SCE) for the 12+/1 redox couple, and make 1 the first organic donor able to reduce malononitriles and diakylarenesulfonamides without photoexcitation.

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