Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 22

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Upcoming Hot Papers

Hot Papers are chosen by the Editors for their importance in a rapidly evolving field of high current interest. Many of the "Very Important Papers" (VIPs) would certainly qualify to be included here, but such a duplication is avoided.

Graphene Nanostructures

The Nanoparticle Size Effect in Graphene Cutting: A “Pac-Man” Mechanism

The Nanoparticle Size Effect in Graphene Cutting: A “Pac-Man” Mechanism

Surface or interface? By employing a multiscale simulation approach, a “Pac-Man” mechanism is revealed for the nickel-nanoparticle-catalyzed cutting of graphene. Although the overall cutting rate is proportional to the surface area of the nanoparticle, it is found that the rate-limiting step is actually at the graphene–metal interface instead of on the nanoparticle surface.

Read more now


 

Atomic-Scale Engineering

Low-Temperature Cationic Rearrangement in a Bulk Metal Oxide

Low-Temperature Cationic Rearrangement in a Bulk Metal Oxide

The unprecedented low-temperature (150–300 °C) cationic rearrangement in bulk Mn2FeMoO6 leads to a transition from a Ni3TeO6-type to an ordered-ilmenite structure, and dramatic changes of the electrical and magnetic properties, which demonstrates remarkable physical property tunneling through atomic-scale manipulation in bulk oxide under mild conditions.

Read more now


 

Photocatalysis

Chromoselective Photocatalysis: Controlled Bond Activation through Light-Color Regulation of Redox Potentials

Chromoselective Photocatalysis: Controlled Bond Activation through Light-Color Regulation of Redox Potentials

I see your two colors, shining through: The xanthene dye rhodamine 6G is a moderately reducing photoredox catalyst if irradiated with green light, but provides an high reduction power of −2.4 V vs. SCE upon blue-light irradiation. This allows control of the selectivity of photocatalytic C−H arylation reactions through changing the color of the light.

Read more now


 

Venom Peptides

Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries

Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries

Pick your poison: Cysteine-knot peptides were extracted from the venom database by using bioinformatics and used to create a lentiviral vector library for the autocrine-based selection of peptides targeting ion channels. Interaction of the membrane-tethered venom peptide with the ion channel results in the protease-mediated release of a transcription factor (orange), which triggers expression of a reporter gene (red).

Read more now


 

Oxygen Reduction

Nitrogen-Rich Manganese Oxynitrides with Enhanced Catalytic Activity in the Oxygen Reduction Reaction

Nitrogen-Rich Manganese Oxynitrides with Enhanced Catalytic Activity in the Oxygen Reduction Reaction

The catalytic activities of manganese oxynitrides with different nitrogen contents in the oxygen reduction reaction (ORR) in alkaline solution were investigated. An increase in the nitrogen content of rock-salt-type manganese oxynitrides increases the valence of manganese and leads to enhanced catalytic activity.

Read more now


 

Molecular Motion

Dissipative and Autonomous Square-Wave Self-Oscillation of a Macroscopic Hybrid Self-Assembly under Continuous Light Irradiation

Dissipative and Autonomous Square-Wave Self-Oscillation of a Macroscopic Hybrid Self-Assembly under Continuous Light Irradiation

Oscillate wildly: In a limit-cycle self-oscillatory motion of a macroscopic assembly, the assembly permanently flips under continuous blue-light irradiation. Mechanical self-oscillation showing a spatio-temporal pattern is established by successively alternating photoisomerization processes and multi-stable phase transitions.

Read more now


 

Spin-Crossover Materials

First Step Towards a Devil's Staircase in Spin-Crossover Materials

First Step Towards a Devil's Staircase in Spin-Crossover Materials

The devil is in the detail: Periodic and aperiodic spin-state concentration waves form during “Devil's staircase”-type spin-crossover in a new bimetallic 2D coordination polymer {Fe[(Hg(SCN)3)2](4,4′-bipy)2}n.

Read more now


 

Analytical Methods

A Disposable Planar Paper-Based Potentiometric Ion-Sensing Platform

A Disposable Planar Paper-Based Potentiometric Ion-Sensing Platform

Paper-based sensors: Embedding a potentiometric cell into paper brings selective ion sensors into the reach of users with limited resources and training. The paper-based device is simple to use, does not need any pretreatment, and requires only a low sample volume of 20 μL. It can be used to detect clinically relevant ions in biological samples with high sensitivity and reproducibility. ISE=ion-selective electrode.

Read more now


 

Heterogeneous Catalysis

Heterogeneous Catalysis for Water Oxidation by an Iridium Complex Immobilized on Bipyridine-Periodic Mesoporous Organosilica

Dr. Xiao Liu, Yoshifumi Maegawa, Dr. Yasutomo Goto, Prof. Kenji Hara and Dr. Shinji Inagaki

Heterogeneous Catalysis for Water Oxidation by an Iridium Complex Immobilized on Bipyridine-Periodic Mesoporous Organosilica

Uncharted waters: Using bipyridine-periodic mesoporous organosilica (BPy-PMO) as a solid chelating ligand, efficient heterogeneous iridium catalysts (Ir-Bpy-PMO) for water oxidation were obtained. This catalyst had an activity comparable to the analogous homogeneous iridium catalyst and showed one order of magnitude higher activity than that of the previously reported heterogeneous iridium catalysts.

Read more now


 

Protein Synthesis

Parallel Chemical Protein Synthesis on a Surface Enables the Rapid Analysis of the Phosphoregulation of SH3 Domains

Robert Zitterbart and Prof. Dr. Oliver Seitz

Parallel Chemical Protein Synthesis on a Surface Enables the Rapid Analysis of the Phosphoregulation of SH3 Domains

A fast track to analyze the phosphoregulation of proteins has been realized by immobilization of peptide hydrazides through hydrazone ligation with self-purified peptide thioesters, a radical-induced desulfurization, and a surface-based binding assay. The method shows that tyrosine phosphorylation can induce both a loss and a gain in the ligand affinity of the SH3 domains of Abl kinases.

Read more now


 

Electrochromic Batteries

Trace H2O2-Assisted High-Capacity Tungsten Oxide Electrochromic Batteries with Ultrafast Charging in Seconds

Jinxiong Zhao, Yuyu Tian, Zhen Wang, Dr. Shan Cong, Prof. Di Zhou, Qingzhu Zhang, Mei Yang, Weikun Zhang, Prof. Fengxia Geng and Prof. Zhigang Zhao

Trace H2O2-Assisted High-Capacity Tungsten Oxide Electrochromic Batteries with Ultrafast Charging in Seconds

A high-performance electrochromic battery with unprecedented charging time down to eight seconds and specific capacity up to 429 mAh g−1 was designed, in which the level of energy stored can be constantly and visually conveyed by recognizing variations in color. The high capacity may come from an intricate combination of structure and valence state changes of the tungsten oxide electrode.

Read more now


 

Supported Catalysts

CO2 Hydrogenation over Oxide-Supported PtCo Catalysts: The Role of the Oxide Support in Determining the Product Selectivity

Dr. Shyam Kattel, Dr. Weiting Yu, Dr. Xiaofang Yang, Dr. Binhang Yan, Yanqiang Huang, Weiming Wan, Dr. Ping Liu and Prof. Dr. Jingguang G. Chen

CO2 Hydrogenation over Oxide-Supported PtCo Catalysts: The Role of the Oxide Support in Determining the Product Selectivity

By simply changing the oxide support, the selectivity of a metal–oxide catalyst can be tuned. For the CO2 hydrogenation over PtCo bimetallic catalysts supported on different reducible oxides, replacing a TiO2 support by CeO2 or ZrO2 selectively strengthens the binding of C,O-bound and O-bound species at the PtCo–oxide interface, leading to a different product selectivity.

Read more now


 

Substrate Channeling

Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold

Guoliang Ke, Dr. Minghui Liu, Shuoxing Jiang, Dr. Xiaodong Qi, Yuhe Renee Yang, Shaun Wootten, Dr. Fei Zhang, Prof. Zhi Zhu, Prof. Yan Liu, Prof. Chaoyong James Yang and Prof. Hao Yan

Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold

Artificial multi-enzyme systems with precise and directional control over the enzyme pathway activities are of great significance in bionanotechnology and synthetic biology. A DNA origami system for the directional regulation of the activities of two enzyme pathways (G6pDH–MDH and G6pDH–LDH) through the control of NAD+ substrate channeling by specifically shifting NAD+ between the two enzyme pairs is now reported.

Read more now


 

Activity-Based Probes

Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity

Dr. Yong Qian, Dr. Marc Schürmann, Dr. Petra Janning, Prof. Dr. Christian Hedberg and Prof. Dr. Herbert Waldmann

Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity

Old dog—new tricks: Woodward's reagent K (WRK) is a reactive heterocyclic compound known to covalently and unspecifically label proteins. A range of WRK-derived activity-based probes were synthesized and shown to be fairly selective for a few proteins in the human proteome.

Read more now


 

Photocatalysis

An Elemental Phosphorus Photocatalyst with a Record High Hydrogen Evolution Efficiency

Dr. Zhuofeng Hu, Luyan Yuan, Prof. Zhifeng Liu, Dr. Zhurui Shen and Prof. Jimmy C. Yu

An Elemental Phosphorus Photocatalyst with a Record High Hydrogen Evolution Efficiency

A breakthrough: Fibrous-phase red phosphorous was used as semiconductor photocatalyst for visible-light-driven hydrogen evolution. The phosphorus in micro-fibrous P/SiO2 and smashed-fibrous phosphorus showed hydrogen evolution rates of 633 μmol h−1 g−1 and 684 μmol h−1 g−1, respectively. These values are records for elemental photocatalysts.

Read more now


 

Fluorine Chemistry

Positioning a Carbon–Fluorine Bond over the π Cloud of an Aromatic Ring: A Different Type of Arene Activation

Maxwell Gargiulo Holl, Mark D. Struble, Prakhar Singal, Dr. Maxime A. Siegler and Prof. Thomas Lectka

Positioning a Carbon–Fluorine Bond over the π Cloud of an Aromatic Ring: A Different Type of Arene Activation

Stabilizing effect of fluorine: A chemical species was synthesized that contained a carbon–fluorine bond positioned tightly over the π cloud of an aromatic ring. This rigid C−F⋅⋅⋅Ar interaction played a prominent role in both its reaction chemistry and spectroscopy. The results establish fluorine as a through-space directing/activating group that complements the traditional role of fluorine as an overall deactivating aryl substituent.

Read more now


 

Protein–Polymer Nanoconjugates

Hierarchical Proteinosomes for Programmed Release of Multiple Components

Dr. Xiaoman Liu, Pei Zhou, Prof. Yudong Huang, Dr. Mei Li, Prof. Xin Huang and Prof. Stephen Mann

Hierarchical Proteinosomes for Programmed Release of Multiple Components

A hierarchical proteinosome architecture comprising three nested layers and different types of encapsulated components was fabricated (see picture). Engineering the cross-links in the host and guest proteinosome membranes gave rise to three different types of programmed release behavior.

Read more now


 

Hybrid Materials

Controlled Exfoliation of Layered Silicate Heterostructures into Bilayers and Their Conversion into Giant Janus Platelets

Matthias Stöter, Sebastian Gödrich, Patrick Feicht, Dr. Sabine Rosenfeldt, Herbert Thurn, Jens W. Neubauer, Maximilian Seuss, Dr. Peter Lindner, Dr. Hussein Kalo, Dr. Michael Möller, Prof. Dr. Andreas Fery, Prof. Dr. Stephan Förster, Prof. Dr. Georg Papastavrou and Prof. Dr. Josef Breu

Controlled Exfoliation of Layered Silicate Heterostructures into Bilayers and Their Conversion into Giant Janus Platelets

Controlled exfoliation of layered silicate heterostructures into bilayers with unprecedented precision by osmotic swelling gives access to a general method for asymmetrical modification of basal planes. Only two simple steps are needed to obtain Janus-type monolayers as bulk material.

Read more now


 

MOF Films

Direct fabrication of Free-Standing MOF Superstructures with Desired Shapes by Micro-Confined Interfacial Synthesis

Jin-Oh Kim, Dr. Kyoung-Ik Min, Hyunwoo Noh, Dong-Hwi Kim, Prof. Dr. Soo-Young Park and Prof. Dr. Dong-Pyo Kim

Direct fabrication of Free-Standing MOF Superstructures with Desired Shapes by Micro-Confined Interfacial Synthesis

Same mold MOFs: Micro-confined interfacial synthesis allows control of the morphologies and dimensions of MOF 2D patterns by growing the MOF films in molds. The free standing 2D MOFs can also be functionalization, by loading them with magnetic nanoparticles, or using luminescent lanthanide ions. Contact transfer allows the selective positioning the MOF arrays on various substrates including glass and skin.

Read more now


 

Heterogeneous Hydrogenation

Pt3Co Octapods as Superior Catalysts of CO2 Hydrogenation

Munir Ullah Khan, Liangbing Wang, Zhao Liu, Zehua Gao, Shenpeng Wang, Hongliang Li, Wenbo Zhang, Menglin Wang, Prof. Zhengfei Wang, Prof. Chao Ma and Prof. Jie Zeng

Pt3Co Octapods as Superior Catalysts of CO2 Hydrogenation

Pt3Co octapods, Pt3Co nanocubes, Pt octapods, and Pt nanocubes were used as catalysts for carbon dioxide hydrogenation. Owing to the multiple sharp tips and the charge transfer between Pt and Co, which leads to the accumulation of negative charge on the Pt atoms in the vertices, the Pt3Co octapods were the most efficient catalyst of this process.

Read more now


 

Metal–Organic Frameworks

Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks

Jihye Park, Dr. Qin Jiang, Dr. Dawei Feng and Prof. Dr. Hong-Cai Zhou

Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks

A switch inside: In situ incorporation of a photosensitizing system into MOF nanoparticles to control 1O2 generation is possible using a tunable ratio of a photochromic switch. The MOF formulation allows enhanced in vitro photodynamic therapy (PDT) efficacy with a superior control of 1O2 production compared to a simple mixture of the dyad.

Read more now


 

Lifetime Engineering

A Macrocyclic Fluorophore Dimer with Flexible Linkers: Bright Excimer Emission with a Long Fluorescence Lifetime

Hiroshi Osaki, Dr. Chih-Ming Chou, Prof. Dr. Masayasu Taki, Dr. Kai Welke, Prof. Dr. Daisuke Yokogawa, Prof. Dr. Stephan Irle, Prof. Dr. Yoshikatsu Sato, Prof. Dr. Tetsuya Higashiyama, Dr. Shohei Saito, Prof. Dr. Aiko Fukazawa and Prof. Dr. Shigehiro Yamaguchi

A Macrocyclic Fluorophore Dimer with Flexible Linkers: Bright Excimer Emission with a Long Fluorescence Lifetime

Brighter and slower: A macrocyclic fluorophore dimer with flexible alkylene linkers exhibited strong absorption, a high fluorescence quantum yield (ΦF), and a slow fluorescence decay (τ) attributable to efficient intramolecular excimer formation. In vitro time-gated imaging experiments were used to demonstrate the superior fluorescence performance of the dimer compared to a commercial fluorescent dye.

Read more now


 

Peptidoglycan

Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance

Dr. Mijoon Lee, Supurna Dhar, Dr. Stefania De Benedetti, Dr. Dusan Hesek, Dr. Bill Boggess, Dr. Blas Blázquez, Prof. Kalai Mathee and Prof. Shahriar Mobashery

Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance

Muropeptides: A total of 20 muropeptides, which are breakdown products of peptidoglycan, were isolated from Pseuromonas aeruginosa and their structures were elucidated. The least abundant of these metabolites is present at 100 and the most abundant at 55 000 molecules per bacterium. Two of these compounds were shown to be involved in the induction of β-lactamase expression. This effect is the basis for resistance to β-lactam antibiotics in P. aeruginosa.

Read more now


 

Self-Assembly

Molecularly Regulated Reversible DNA Polymerization

Dr. Niancao Chen, Xuechen Shi and Prof. Dr. Yong Wang

Molecularly Regulated Reversible DNA Polymerization

Reversible DNA polymerization: Linear and branched DNA polymers were synthesized and decomposed using molecular triggers under physiological conditions (see picture). The polymerization mechanism is based on the well-known hybridization chain reaction.

Read more now


 

Nanocrystal Assemblies

3D Assembly of All-Inorganic Colloidal Nanocrystals into Gels and Aerogels

Vladimir Sayevich, Bin Cai, Albrecht Benad, Danny Haubold, Luisa Sonntag, Prof. Nikolai Gaponik, Dr. Vladimir Lesnyak and Prof. Alexander Eychmüller

3D Assembly of All-Inorganic Colloidal Nanocrystals into Gels and Aerogels

An assembly approach for a variety of electrostatically stabilized all-inorganic semiconductor nanocrystals is based on their linking with appropriate ions into multibranched gel networks. The resulting aerogels are highly porous monolithic structures, which preserve the quantum confinement of their building blocks.

Read more now


 

Droplet Microfluidics

Quantitative Single-Cell mRNA Analysis in Hydrogel Beads

Agata Rakszewska, Rosa J. Stolper, Anna B. Kolasa, Dr. Aigars Piruska and Prof. Dr. Wilhelm T. S. Huck

Quantitative Single-Cell mRNA Analysis in Hydrogel Beads

Catch me if you can: Hydrogel beads functionalized with LNA (locked nucleic acid) can serve as a matrix to capture mRNA from lysed single cells. mRNA quantification free of pre-amplification bias is ensured by using padlock probes and rolling circle amplification followed by hybridization with fluorescent probes. The number of transcripts in individual cells is assessed by counting fluorescent dots inside gel beads. Scale bar=50 µm.

Read more now


 

SEARCH

SEARCH BY CITATION