Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 35

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

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A Larger Pocket - Reprogramed nonribosomal peptide synthetase incorporates amino acids with reactive sites for “click” chemistry

Latest News

A Larger Pocket

Reprogramed nonribosomal peptide synthetase incorporates amino acids with reactive sites for “click” chemistry.
A single targeted mutation is enough to alter a natural peptide system so that it also incorporates non-natural amino acids into peptides, report Swiss scientists in the journal Angewandte Chemie. The mutation increases the size of the binding cavity in one domain of the system, which changes the substrate specificity. The researchers are thus able to incorporate amino acids with a specific reactive group that can later be used to easily modify the peptide.

Read more.

No.Press ReleaseOriginal Communication

32/2014

Planet–Satellite Nanostructures Made To Order by RAFT Star Polymers

Philipp Vana, Universität Göttingen (Germany)


31/2014

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

K. Barry Sharpless, The Scripps Research Institute, La Jolla (USA)


30/2014

A Larger Pocket
Reprogramed nonribosomal peptide synthetase incorporates amino acids with reactive sites for “click” chemistry
(PDF)

Reprogramming Nonribosomal Peptide Synthetases for "Clickable" Amino Acids

Donald Hilvert, ETH Zürich (Switzerland)


29/2014

Textile Solar Cells
Affordable and inexpensive: flexible fiber perovskite solar cells
(PDF)

Integrating Perovskite Solar Cells into a Flexible Fiber

Huisheng Peng, Fudan University, Shanghai (China)


28/2014

Hope for the Honey Bee?
Peptide-polyketide antibiotic from the pathogen that causes American Foulbrood
(PDF)

Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvae

Roderich Süssmuth, Technische Universität Berlin (Germany)


27/2014

Dating by Electrode
Voltammetry of microparticles used to date archeological artifacts made of copper and bronze
(PDF)

Dating Archaeological Copper/Bronze Artifacts by Using the Voltammetry of Microparticles

Antonio Doménech-Carbó, Universitat de València (Spain)


26/2014

Cholera: Fighting Fire with Fire
Binding at five sites: effective cholera inhibitor based on cholera toxins
(PDF)

A Protein-Based Pentavalent Inhibitor of the Cholera Toxin B-Subunit

W. Bruce Turnbull, University of Leeds (United Kingdom)


25/2014

A Sink for Signals
Triplex RNA motif binds cellular cGMP after expression in mammalian cells
(PDF)

Endless: A Purine Binding Motif that Can Be Expressed in Cells

Clemens Richert, Universität Stuttgart (Germany)


24/2014

Follow Your Nose
Odor code for food is based on a few volatile substances
(PDF)

Nature's Chemical Signatures in Human Olfaction: A Foodborne Perspective for Future Biotechnology

Thomas Hofmann, Technische Universität München (Germany)


23/2014

Drug Sensing by a Synthetic Receptor
Nanomechanical detection of methamphetamines and designer drugs
(PDF)

Cavitand-Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water

Enrico Dalcanale, Università degli Studi di Parma (Italy)


22/2014

A Battery up Your Sleeve
Elastic wire-shaped lithium ion batteries with high electrochemical performance
(PDF)

Elastic and Wearable Wire-Shaped Lithium-Ion Battery with High Electrochemical Performance

Huisheng Peng, Fudan University, Shanghai (China)


21/2014

Go with the Flow
Flow-through peptide synthesis and cell-based assays on Teflon-coated paper
(PDF)

Flow-Through Synthesis on Teflon-Patterned Paper to Produce Peptide Arrays That Can Be Used for Cell-Based Assays

Ratmir Derda, University of Alberta, Edmonton (Canada)


20/2014

Carbon-Based Electronics in Sight?
Triazine-based, graphitic carbon nitride as novel two-dimensional semiconductor
(PDF)

Triazine-Based, Graphitic Carbon Nitride: a Two-Dimensional Semiconductor

Andrew I. Cooper, University of Liverpool (UK)


19/2014

Effective Cesium Radioisotope Removal
Novel vanadosilicate is potential decontamination agent for cesium-tainted water
(PDF)

A Novel Vanadosilicate with Hexadeca-Coordinated Cs+ Ions as a Highly Effective Cs+ Remover

Kyung Byung Yoon, Sogang University, Seoul (Rep. Korea)


18/2014

Wearable Solar Cells
Solar cells based on stacked textile electrodes for integration into fabrics
(PDF)

Wearable Solar Cells by Stacking Textile Electrodes

Huisheng Peng, Fudan University, Shanghai (China)


17/2014

Beyond Elastic
Organic crystal demonstrates superelasticity
(PDF)

A Superelastic Crystal of Terephthalamide

Satoshi Takamizawa, Yokohama City University (Japan)


16/2014

Clear Pathways
A potential candidate for more efficient solid oxide bismuth and iridium fuel cells
(PDF)

A Metallic Room-Temperature Oxide Ion Conductor

Michael Ruck, Technische Universität Dresden (Germany)


15/2014

Nanoparticles Replace Needle and Thread
Wound closure and organ repair with nanoparticle solutions
(PDF)

Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles

Ludwik Leibler, ESPCI ParisTech (France)


14/2014

Pearls to Prevent Relaxation
Additive stops aging in super glassy polymer membranes
(PDF)

Ending Aging in Super Glassy Polymer Membranes

Matthew R. Hill, CSIRO Division of Materials Science and Engineering, Clayton South (Australia)


13/2014

Versatile Capsules
Multifunctional microcapsules made from metals and tannic acid
(PDF)

Engineering Multifunctional Capsules through the Assembly of Metal–Phenolic Networks

Frank Caruso, University of Melbourne (Australia)


12/2014

From Stench to Resource
Production of sulfur and hydrogen: splitting hydrogen sulfide with solar energy
(PDF)

An Integrated Photoelectrochemical–Chemical Loop for Solar-Driven Overall Splitting of Hydrogen Sulfide

Lianzhou Wang, University of Queensland (Australia)


11/2014

Swelling Stacks
Optical components made of multiresponsive microgels
(PDF)

Optical Devices Constructed from Multiresponsive Microgels

Michael J. Serpe, University of Alberta, Edmonton (Canada)


10/2014

Tracking Down the Ash Tree Killer
Volatile lactone of Hymenoscyphus pseudoalbidus inhibits germination of ash seeds
(PDF)

A Volatile Lactone of Hymenoscyphus pseudoalbidus, Pathogen of European Ash Dieback, Inhibits Host Germination

Jeroen S. Dickschat, Technische Universtiät Braunschweig (Germany)


09/2014

Spinning Drops of Blood
Better diagnosis of parasitic infections: rapid, simple enrichment of rare cells by using ultrasound
(PDF)

Rare-Cell Enrichment by a Rapid, Label-Free, Ultrasonic Isopycnic Technique for Medical Diagnostics

Jonathan M. Cooper, University of Glasgow (UK)


08/2014

Gel Filled Filter—More than a Pore
Microgel-based thermoresponsive membranes for water filtration
(PDF)

Temperature-Modulated Water Filtration Using Microgel-Functionalized Hollow-Fiber Membranes

Matthias Wessling, RWTH Aachen (Germany)


07/2014

Molecular Hinges Open Pathways
Exchange of bismuth atoms for chloride ions with retention of structure
(PDF)

The Topochemical Pseudomorphosis of a Chloride into a Bismuthide

Michael Ruck, Technische Universität Dresden (Germany)


06/2014

Iron Oxide as an Ultralightweight
Iron oxide frameworks with hierarchical pore structure from pyrolysis of Prussian blue nanocrystals
(PDF)

Ultralight Mesoporous Magnetic Frameworks by Interfacial Assembly of Prussian Blue Nanocubes

Dongyuan Zhao, Fudan University, Shanghai (China)


05/2014

Chains of Gold and Palladium
Copolymerization of metal nanoparticles for the production of colloidal plasmonic copolymers
(PDF)

Copolymerization of Metal Nanoparticles: A Route to Colloidal Plasmonic Copolymers

Eugenia Kumacheva, University of Toronto (Canada)


04/2014

Micro-Patchwork Family
3D construction: microparticles made of three chemically independent patches
(PDF)

Chemically Orthogonal Three-Patch Microparticles

Joerg Lahann, University of Michigan, Ann Arbor (USA)


03/2014

Color without Dyes
New non-iridescent structural colors cover the whole spectrum
(PDF)

Full-Spectrum Photonic Pigments with Non-iridescent Structural Colors through Colloidal Assembly

Vinothan N. Manoharan, Harvard University, Cambridge (USA)


02/2014

Silenced
Overcoming multidrug resistance in cancer cells by silencing genes with RNA
(PDF)

Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells

Xiaoyuan Chen, National Institutes of Health (NIH), Bethesda (USA)


01/2014

A New Approach to Malaria Treatment?
Halogenated natural alkaloids show herbicidal and antiplasmodial activity
(PDF)

Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD

François Diederich, ETH Zürich (Switzerland)


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