Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 35

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

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Table of
Press ReleaseOriginal Communication


Killing Resistant Germs
Paromomycin derivative as a potential drug against multiple-resistant Staphylococci

Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Stephen Hanessian, Univ. Montréal (Canada)


Detachable Nanoglue
Nanoscopic gold spheres can be reversibly bound to DNA strands

Reversible Switching of DNA–Gold Nanoparticle Aggregation

Christoph M. Niemeyer, Univ. Dortmund (Germany)


Protein with Pores
"Biozeolites": Peptides as a new class of microporous organic solids

Dipeptides as Microporous Materials

Dimitriy V. Soldatov / John A. Ripmeester, Russian Academy of Sciences, Novosibirsk / Steacie Inst. of Molecular Sciences, Ottawa (Canada)


Watch your Step!
Aligned nanowires: carbon nanotubes grow along atomic steps on sapphire surfaces

Atomic-Step-Templated Formation of Single Wall Carbon Nanotube Patterns

Ernesto Joselevich, Weizmann Institute of Science, Rehovot (Israel)


Uncovered by Weight Gain
Enzyme tests with peptide chips and mass spectrometry

Profiling Kinase Activities by Using a Peptide Chip and Mass Spectrometry

Milan Mrksich, University of Chicago (USA)


Solution to a Mystery
The structure of a polymeric carbon suboxide is finally cleared up

Analysis of Poly(carbon suboxide) by Small-Angle X-ray Scattering

Matthias Ballauf, Universität Bayreuth (Germany)


Copying Mother Nature
Organic molecules spontaneously organize themselves into large spherical structures

Finite, Spherical Coordination Networks that Self-Organize from 36 Small Components

Makoto Fujita, University of Tokyo (Japan)


Toy from the Molecular Construction Set
A molecule that looks like a toy top can serve as a motor for nanoscale components

Molecular Gyroscopes: {Fe(CO)3}- and {Fe(CO)2(NO)}+ Rotators Encased in Three-Spoke Stators; Facile Assembly by Alkene Metatheses

John A. Gladysz, Universität Erlangen-Nürnberg (Germany)


A new method for coating individual luminous nanocrystals (quantum dots) with silicon dioxide

Single Quantum Dots in Spherical Silica Particles

Thomas Nann, Universität Freiburg (Germany)


Nanoneedle for the Injection of Genes?
Carbon nanotubes slip DNA into cells—a new approach to gene therapy?

Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery

Alberto Bianco, CNRS, IBMC Strasbourg (France)


Lord of the Rings—Chemical magic tricks
Selective formation of cross-catenanes—pairs of different interlocking molecular rings

Kinetic Self-Assembly: Selective Cross-Catenation of Two Sterically Differentiated PdII-Coordination Rings

Makoto Fujita, The University of Tokyo (Japan)


Autonomous nanomachine: a DNA fragment moves along a self-organized DNA track

A Unidirectional DNA Walker That Moves Autonomously along a Track

Hao Yan, Duke University, Durham, NC (USA)


Scaring off Mosquitoes
Total synthesis of gaur acid reveals the spatial structure of this proposed yellow-fever mosquito repellant

Stereodivergent Construction of Cyclic Ethers by a Regioselective and Enantiospecific Rhodium-Catalyzed Allylic Etherification: Total Synthesis of Gaur Acid

P. Andrew Evans, Indiana University, Bloomington, IN (USA)


Cancer Drug from Sea Sponges?
Two research teams succeed in synthesizing Dictyostatin—confirming the proposed structure of this natural product

Total Synthesis and Configurational Assignment of (-)-Dictyostatin, a Microtubule-Stabilizing Macrolide of Marine Sponge Origin; Total Synthesis of (-)-Dictyostatin: Confirmation of Relative and Absolute Configurations

Ian Paterson / Dennis P. Curran , Universities of Cambridge (UK) / Pittsburgh (USA)


More Potential Side-Effects than Previously Thought
Does the activity of chromium in "slimming agents" stem from the formation of cancer-causing substances?

Biomimetic Oxidation of Chromium(III): Does the Antidiabetic Activity of Chromium(III) Involve Carcinogenic Chromium(VI)?

Peter A. Lay, University of Sydney (Australia)


Plastic with a Lotus Effect
It's in the combination: a super-water-repellent polystyrene film made of microspheres and nanothreads

A Lotus-Leaf-like Superhydrophobic Surface: A Porous Microsphere/Nanofiber Composite Film Prepared by Electrohydrodynamics

Lei Jiang, Chinese Academy of Sciences, Beijing (China)


Phosphorus Nanorods
Two new forms of elemental phosphorus: rod-shaped molecular chains of phosphorus cages

Phosphorus Nanorods—Two Allotropic Modifications of a Long-Known Element

Arno Pfitzner, Univ. Regensburg (Germany)


Breakwater against Diabetes
A new approach to type II diabetes? "Beta-breaker" should break up incorrectly folded, destructive protein structures

Inhibition of Amyloid Fibril Formation by Peptide Analogues Modified with α-Aminoisobutyric Acid

Ehud Gazit, Tel Aviv University (Israel)


Rare Sugar
Unusual carbohydrate structure in the cell walls of tuberculosis bacteria—a new point of attack for drugs?

Identification of the 5-Methylthiopentosyl Substituent in Mycobacterium tuberculosis Lipoarabinomannan

Achim Treumann, Royal College of Surgeons, Dublin (Ireland)


Reinforcing the Immune System
Small difference, large effect: fully synthetic drug is orders of magnitude more effective than naturally occurring analogue

The C-Glycoside Analogue of the Immunostimulant α-Galactosylceramide (KRN7000): Synthesis and Striking Enhancement of Activity

Richard W. Franck, City University of New York (USA)


Will Computers Think, Machines Invent, and Humans Live Forever?
Harvard Chemist G. Whitesides on the Future

Assumptions: Taking Chemistry in New Directions

George M. Whitesides, Harvard Univ., Cambridge (USA)


Platonic Gold
Producing Gold nanocrystals with defined geometric shapes

Platonic Gold Nanocrystals

Peidong Yang, UC Berkeley (USA)


Piecing together the Natural Product Puzzle
Structure determination and synthesis of the mussel toxin azaspiracid

Structural Revision and Total Synthesis of Azaspiracid-1 (Part I+II)

K. C. Nicolaou, The Scripps Research Institute, La Jolla, CA (USA)


Molecular Hand
DNA-based molecular machine that reversibly grabs and then releases thrombin

A DNA-Based Machine That Can Cyclically Bind and Release Thrombin

Friedrich C. Simmel, Univ. München (Germany)


Open and shut detection
Electrochemical sensor for the uncomplicated detection of "hits" on DNA chips

Label-Free Electrochemical Recognition of DNA Hybridization by Means of Modulation of the Feedback Current in SECM

Wolfgang Schuhmann, Univ. Bochum (Germany)


DNA as a Template for Minerals
Copying DNA structures with silicates— a step toward ordered synthetic inorganic materials?

Sol–Gel Reaction Using DNA as a Template: An Attempt Toward Transcription of DNA into Inorganic Materials

Seiji Shinkai, Kyushu University (Japan)


Bottle Brushes Tête à Tête
Copolymers made of one coil- and one rod-shaped block congregate in giant micelles

Micelle Formation from Amphiphilic "Cylindrical Brush"—Coil Block Copolymers Prepared by Metallocene Catalysis

Manfred Schmidt, Univ. Mainz (Germany)


Fishing for Proteins
Magnetic gold and nickel nanorods for the separation of biomolecules

Multicomponent Magnetic Nanorods for Biomolecular Separations

Chad A. Mirkin, Northwestern University, Evanston, IL (USA)


A Goblet for Gases
Calixarene crystals as new absorption agents for the purification of hydrogen

A New Type of Material for the Recovery of Hydrogen from Gas Mixtures

Leonard J. Barbour, University of Stellenbosch (South Africa)


Finely Divided
New process for the production of efficient catalyst systems for the synthesis of methanol

MOCVD-Loading of Mesoporous Siliceous Matrices with Cu/ZnO: Supported Catalysts for Methanol Synthesis

Roland A. Fischer, Ruhr-Universität Bochum (Germany)


Thought Experiment with Golden Balls
Computer calculations predict an unusual gold cluster: a fullerene made of 32 gold atoms

Au32: A 24-Carat Golden Fullerene

Mikael P. Johansson, University of Helsinki (Finland)


Crystals by the Drop
High-throughput process for the optimization of crystallization conditions for proteins

A Droplet-Based, Composite PDMS/Glass Capillary Microfluidic System for Evaluating Protein Crystallization Conditions by Microbatch and Vapor-Diffusion Methods with On-Chip X-Ray Diffraction

Rustem Ismagilov, University of Chicago (USA)


Responsibility for the Weaker
Environmental protection and chemical security in developing countries—a mutual burden

Chemical Safety in a Vulnerable World—A Manifesto

C. Djerassi, Stanford University (USA)


"Drawing" with Nanoparticles
Defined patterns of gold nanoparticles in transparent materials—optoelectronic building blocks of the future?

Manipulation of Gold Nanoparticles inside Transparent Materials

Colored butterfly

Jianrong Qiu, Shanghai Institute of Optics and Fine Mechanics (China)


Needle in a Haystack
Magnetic-bioelectronic protein diagnosis is super-sensitive and has potential for use on lab-on-chips

DNA-Based Amplified Bioelectronic Detection and Coding of Proteins

Joseph Wang, New Mexico State University (USA)


Liberated Lithium Ions
Additive speeds the efficiency of lithium-ion accumulators

A High Electrode-Reaction Rate for High-Power-Density Lithium-Ion Secondary Batteries by the Addition of a Lewis Acid

Masataka Wakihara, Tokyo Institute of Technology (Japan)


Common Mushrooms as Synthetic Geniuses
Yellow pigments with unusual structures from common earthball and peppery bolete?

Unusual Pulvinic Acid Dimers from the Common Fungi Scleroderma citrinum (Common Earthball) and Chalciporus piperatus (Peppery Bolete)

Wolfgang Steglich, Univ. München (Germany)


Iron Complex with a Killer Instinct
Iron-containing nucleoside analogs kill tumor cells—organometallic compounds as a new class of drugs?

Iron-Containing Nucleoside Analogues with Pronounced Apoptosis-Inducing Activity

Hans-Günter Schmalz, Univ. Köln (Germany)


Three Colors: Green
Electrically conducting green polymer completes the three primary colors—a step toward a plastic display?

A Red, Green, and Blue (RGB) Polymeric Electrochromic Device (PECD): The Dawning of the PECD Era

Fred Wudl, University of California, Los Angeles (USA)


Rock ‘n’ Roll Down the Tubes
Metal-filled fullerenes are "hopping" inside of carbon nanotubes

Molecular Motion of Endohedral Fullerenes in Single-Walled Carbon Nanotubes

Andrei N. Khlobystov, Oxford University (UK)


Platinum nanoparticles "burrow" into a zeolite support and form new pores

Mesopores Created by Platinum Nanoparticles in Zeolite Crystals

Hitoshi Kato, Japan Fine Ceramics Center, Nagoya (Japan)


Reactor made of Gold Tubes
Gold nanotubes in polycarbonate films for the investigation of catalytic reactions at gas-liquid phase boundaries

Gold-Nanotube Membranes for the Oxidation of CO at Gas-Water Interfaces

James A. Dumesic, University of Wisconsin, Madison (USA)


Cleaner Fuel
Removing nitrogen compounds from diesel by adsorption onto copper-containing zeolites

Denitrogenation of Transportation Fuels by Zeolites at Ambient Temperature and Pressure

Ralph T. Yang, University of Michigan (USA)


Winterproof Fish
Which structural characteristics make glycoproteins into good antifreezes?

Antifreeze Glycoproteins: Elucidation of the Structural Motifs That Are Essential for Antifreeze Activity

Shin-Ichiro Nishimura, Hokkaido Univ. (Japan)


Environmentally Friendly Silicon Production
Electrochemical extraction of silicon: new approach for a more environmentally friendly large-scale process?

Electrochemical Preparation of Silicon and Its Alloys from Solid Oxides in Molten Calcium Chloride

George Z. Chen, University of Nottingham (UK)


Wedged In
A jump in porosity: the incusion of small molecules changes the distance between layers in lamellar material

Solid-State Reshaping of Crystals: Flash Increase in Porosity of Zirconium Phosphate-Hypophosphite That Contains Polyethylenoxa Diphosphonate Pillars

Ernesto Brunet, Universidad Autónoma de Madrid (Spain)


Pocket-sized HIV-Diagnostic Lab
Affordable for developing countries too: Prototype of a portable detector for protein diagnosis

An Integrated Approach to a Portable and Low-Cost Immunoassay for Resource-Poor Settings

George M. Whitesides, Harvard University (USA)


Arsenic in Sheep’s Clothing
Organic arsenic-sulfur compound discovered in sheep urine—is arsenic metabolism more complex than expected?

2-Dimethylarsinothioyl Acetic Acid Identified in a Biological Sample: The First Occurrence of a Mammalian Arsinothioyl Metabolite

Jörg Feldmann, Univ. Aberdeen (UK)


Nanoscale Ladders
Synthesis of ladderlike molecules (ladderanes) by reaction in the solid state

Supramolecular Construction of Molecular Ladders in the Solid State

Leonard R. MacGillivray, Univ. of Iowa (USA)


Stacked Rosettes
Stepwise self-organization of molecules into hexameric rosettes and then into nanotubes

π-Conjugated Oligo-(p-phenylenevinylene) Rosettes and Their Tubular Self-Assembly

E. W. Meijer, TU Eindhoven (The Netherlands)