Angewandte Chemie International Edition

(P)Review

Reviews in Angewandte Chemie, written by leading experts, summarize the important results of recent research on topical subjects in all branches of chemistry, point to unresolved problems, and discuss possible developments. Although review articles are generally written upon invitation of the editor, unsolicited manuscripts are also welcome provided they are in keeping with the character of the journal.

Index of Reviews: 1962–1969   1970–1979   1980–1989   1990–1999   2000–2009 2010–now   Nobel lectures

Organometallic Catalysis

The N–H Functional Group in Organometallic Catalysis

Baoguo Zhao, Zhaobin Han, Kuiling Ding*

The "magic" effects of N–H moieties in organometallic catalysis have been observed in various reaction systems. Recent advances are presented in the development of organometallic catalysts based on the concept of cooperative catalysis by taking the beneficial effect of the NH moiety in the catalyst by catalyst–substrate, ligand–ligand, and catalyst–catalyst interactions.

To appear in issue 18/2013.

Published online on March 7, 2013,
DOI: 10.1002/anie.201204921

Main Group Organometallic Chemistry

Structurally Defined Allyl Compounds of Main Group Metals: Coordination and Reactivity

Crispin Lichtenberg, Jun Okuda*

No longer an aside: The allyl chemistry of main group metals was traditionally less investigated, but there is now a fundamental understanding of metal–allyl interactions. Furthermore, reactivity trends and new allyl-specific reaction patterns have been identified. In this Review, the coordination modes and reactivity of allyl compounds of main group metals as well as trends in the periodic system of the elements (PSE) are discussed.

To appear in issue 20/2013.

Published online on April 5, 2013,
DOI: 10.1002/anie.201208942

Proteasome Inhibitors

Synthesis and Pharmacology of Proteasome Inhibitors

Andreas Rentsch, Dirk Landsberg, Tobias Brodmann, Leila Bülow, Anna-Katharina Girbig, Markus Kalesse*

The ubiquitin–proteasome system controls fundamental processes such as cell cycle regulation, DNA repair, apoptosis, and immune and inflammatory responses, as well as hereditary disorders such as cystic fibrosis. This Review covers the synthesis of the most important proteasome inhibitors as well as their mode of action and clinical development.

To appear in issue 21/2013.

Published online on March 25, 2013,
DOI: 10.1002/anie.201207900

Enzyme Design

Computational Enzyme Design

Gert Kiss, Nihan Çelebi-Ölçüm, Rocco Moretti, David Baker, K. N. Houk*

The "inside-out" approach to computer-based enzyme design unites the newest developments in the areas of computational chemistry and biology. This has enabled the design of proteins that catalyze reactions not accelerated in nature. The achievements and limitations of the current technology are highlighted and compared to other methods.

To appear in issue 22/2013.

Published online on March 25, 2013,
DOI: 10.1002/anie.201204077

Spectroscopic Methods

Nanoscale Chemical Imaging Using Tip-Enhanced Raman Spectroscopy: A Critical Review

Thomas Schmid, Lothar Opilik, Carolin Blum, Renato Zenobi*

Getting to the point: Tip-enhanced Raman spectroscopy (TERS) combines the chemical information of Raman spectroscopy experiments with a high signal enhancement and high spatial resolution. The current status of the technique is described together with the shortcomings and pitfalls that have to be considered for spectroscopic imaging by TERS.

To appear in issue 23/2013.

Published online on April 22, 2013,
DOI: 10.1002/anie.201203849

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

C–C Bond Formation

Asymmetric Carbon–Carbon Bond Formation under Continuous-Flow Conditions with Chiral Heterogeneous Catalysts

Tetsu Tsubogo, Takanori Ishiwata, Shū Kobayashi*

One of the most efficient ways to obtain optically active compounds is by the title reaction, but the efficiency of the catalysts is often lower than that in some other reactions, such as asymmetric hydrogenation. The efficiency of such reactions could be solved by using chiral heterogeneous catalysts in continuous-flow systems, which have several advantages over conventional batch systems.

Coming soon.

G-Protein-Coupled Receptors

The Structural Basis of G-Protein-Coupled Receptor Signaling (Nobel Lecture)

Brian Kobilka*

Cells from different parts of our bodies communicate with each other using chemical messengers in the form of hormones and neurotransmitters. They process information encoded in these chemical messages using G-protein-coupled receptors (GPCRs) located in the plasma membrane. The Nobel Prize for Chemistry 2012 was awarded for studies on GPCRs.

Coming soon.

Published online on May 6, 2013,
DOI: 10.1002/anie.201302116

CO₂ Photoreduction

Photocatalytic Reduction of CO₂ on TiO₂ and Other Semiconductors

Severin N. Habisreutinger, Lukas Schmidt-Mende*, Jacek K. Stolarczyk*

It cuts both ways: The photocatalytic conversion of CO₂ into valuable solar fuels such as methane or methanol has the potential to address the future energy supply needs and mitigate CO₂ emissions. This Review presents the current state of the art of the heterogeneous photocatalytic reduction of CO₂ on TiO₂ and other metal oxides, oxynitrides, sulfides, and phosphides. The mechanisms and the measures of the efficiency of the process are discussed in detail.

Coming soon.

Nanostructures

Emerging Strategies for the Total Synthesis of Inorganic Nanostructures

Matthew R. Buck, Raymond E. Schaak*

Nanoscale total synthesis: Diverse nanoparticle reaction libraries can be applied sequentially and predictably to construct complex multicomponent nanoscale architectures, in analogy to the total synthesis concept used to construct large and complex molecules.

Coming soon.

Published online on April 22, 2013,
DOI: 10.1002/anie.201207240

Lithium Batteries

Thermodynamics of Electrochemical Lithium Storage

Professor Joachim Maier*

No defects, no equilibrium: The equilibrium properties of electrochemical storage of lithium in solids are treated bearing in mind that defects in solids are the mechanistically relevant centers. Nanomaterials and amorphous materials are dealt with in the context of constrained equilibria. Finally, it is shown that the application of defect chemistry also allows for a pertinent thermodynamic treatment of interfacial storage.

Coming soon.

Published online on April 29, 2013,
DOI: 10.1002/anie.201205569

G-Protein-Coupled Receptors

A Brief History of G-Protein Coupled Receptors (Nobel Lecture)

Robert J. Lefkowitz*

The idea of receptors has fascinated scientists for more than a century. Today it is known that the G-protein coupled receptors (GPCRs) represent by far the largest, most versatile and most ubiquitous of the several families of plasma membrane receptors. The Nobel Prize for Chemistry 2012 was awarded for studies on GPCRs.

Coming soon.

Published online on May 6, 2013,
DOI: 10.1002/anie.201301924