Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Reviews in Angewandte Chemie, written by leading experts, summarize the important results of recent research on topical subjects in all branches of chemistry, point to unresolved problems, and discuss possible developments. Although review articles are generally written upon invitation of the editor, unsolicited manuscripts are also welcome provided they are in keeping with the character of the journal.
Sarah J. Reinholt, Prof. Antje J. Baeumner
It′s a small world: Many nucleic acid isolation techniques have been miniaturized and integrated into microfluidic devices, each having their own advantages and disadvantages, as well as (potential) applications. The techniques presented include using silica-based surfaces, functionalized paramagnetic beads, oligonucleotide-modified polymer surfaces, pH-dependent charged surfaces, and aluminum oxide membranes.
Prof. Dr. Harald F. Krug
A question of safety: This Review discusses how far the human toxicological evaluation of synthetic nanomaterials has come, for which over 10 000 publications have appeared since 2000. Four core themes have been analyzed: the uptake of nanomaterials by the three main pathways of the lungs, gastrointestinal tract, and skin as well as the assessment of the methods for lung exposure studies.
Dr. Gebrekidan Gebresilassie Eshetu, Prof. Dr. Michel Armand, Prof. Dr. Bruno Scrosati, Prof. Dr. Stefano Passerini
Functional ionic liquids (ILs) are appealing eco-friendly solvents for the synthesis of tailor-made inorganic compounds of use in energy storage devices. Their peculiar properties, such as low volatility, wide liquidus range, high thermal stability, and large electrochemical window, make them suitable as functional advanced materials, media for materials production, and components for preparing highly engineered functional products.
Dr. Tianmeng Sun, Dr. Yu Shrike Zhang, Bo Pang, Dr. Dong Choon Hyun, Miaoxin Yang, Prof. Younan Xia
On the way to nanomedicine: Considerable advances in the development of nanoparticles for cancer therapy have been made in recent years. Nanoparticle-based drug-delivery systems offer advantages with regard to multidrug resistance, systemic delivery, and clearance, and enable for example specific tumor targeting and controlled release of therapeutic agents.
Dr. Timothy A. Hill, Dr. Nicholas E. Shepherd, Dr. Frederik Diness, Prof. Dr. David P. Fairlie
Short peptides can be constrained by cyclization to recreate key folded elements of protein structure, like β-strands and β-sheets, α-helices, and turn motifs. Coupled with internal molecular constraints, cyclization has led to many protease-resistant, potent and target-selective, biologically active compounds for use in biology and medicine.
Prof. Dr. Ilan Marek, Dr. Ahmad Masarwa, Dr. Pierre-Olivier Delaye, Dr. Markus Leibeling
Open, sesame! The creation of new bonds has dominated the field of organic synthesis; however, selective CC cleavage (see scheme) is an important alternative for the construction of interesting molecular frameworks. This Review examines approaches to the synthesis of challenging acyclic molecular skeletons by the regio-, diastereo-, or enantioselective cleavage of carbon–carbon bonds, with a focus on the ring opening of small rings.
Prof. Dr. Yasutomo Segawa, Takehisa Maekawa, Prof. Dr. Kenichiro Itami
By no means π in the sky! The activation of aromatic CH bonds by a transition metal catalyst has received significant attention in the synthetic chemistry community. In recent years, rapid and site-selective extension of π-electron systems by C–H activation has emerged as an ideal methodology for preparing conjugated organic materials. This Review focuses on recently developments in this area directed toward new optoelectronic materials.
Dr. Nicholas H. Evans, Prof. Paul D. Beer
Since the start of this millennium, anion supramolecular chemistry has evolved substantially beyond the chemistry of anion receptors. Alongside the research that continues on the binding and sensing of anions, large strides have been made in areas which have previously been underdeveloped, such as the use of anions as templates and for membrane transportation, and importantly in chemical applications including catalysis, ion extraction, and responsive molecular systems.
Prof. Dr. Reinhard Niessner
What is soot? Soot nanoparticles produced by engines are a threat to human health. The comprehensive characterization of soot will be essential to meet future low-emission standards. This Review describes the many properties of soot nanoparticles and the possibilities to characterize them, from analysis of its morphology and biological reactivity, to its simple combustion, photoacoustic spectroscopy, and Raman scattering.
Formation of Nanoparticles and Nanostructures—An Industrial Perspective on CaCO3, Cement, and Polymers
Dr. Jens Rieger, Dr. Matthias Kellermeier, Dr. Luc Nicoleau
Intermediate nanostructures occurring during crystallization reactions play an important role in understanding and controlling the formation of particles and hybrid materials. The use of polymers allows the range of achievable properties to be broadened through their specific effects at the nanoscale—as is exemplified in this Review with calcium carbonate, zinc oxide, and cementitious systems.
Prof. James Edward Rothman
Cells contain small membrane-enclosed vesicles which transport many kinds of cargo between the compartments of the cell. The result is a choreographed program of secretory, biosynthetic and endocytic protein traffic that serves the cell’s internal physiologic needs.