Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Reviews in Angewandte Chemie, written by leading experts, summarize the important results of recent research on topical subjects in all branches of chemistry, point to unresolved problems, and discuss possible developments. Although review articles are generally written upon invitation of the editor, unsolicited manuscripts are also welcome provided they are in keeping with the character of the journal.
Martin Büschleb, Stéphane Dorich, Stephen Hanessian, Daniel Tao, Kyle B. Schenthal, Larry E. Overman
Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms
Raising the bar: The impressive achievements in the total synthesis of complex natural products containing two or three stereogenic contiguous quaternary carbon centers since 1953 are showcased through the many creative strategies. The height of the “synthesis bar” can now be raised to consider hitherto unconquered molecules with multiple contiguous quaternary carbon atoms, each residing on a stereogenic carbon atom.
Angew. Chem. Int. Ed. 10.1002/anie.201507549
Won-jin Chung, Christopher D. Vanderwal
Stereoselective Halogenation in Natural Product Synthesis
With thousands of natural products containing halogen-bearing stereogenic centers, a wealth of methods have been developed for their stereocontrolled introduction in the context of total synthesis. This Review highlights the creative ways in which organic chemists have dealt with the challenges of stereochemically rich, halogenated natural products.
Angew. Chem. Int. Ed. 10.1002/anie.201506388
Erika A. Crane, Karl Gademann
Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis
Less is more: The desired biological activity of structurally complex natural products can be captured in small, truncated fragments. This process is enabled by chemical synthesis, which guides the discovery process and allows the secrets enshrined in natural products to be unlocked.
Angew. Chem. Int. Ed. 10.1002/anie.201505863
Hari Krishna Bisoyi, Quan Li
Light-Directed Dynamic Chirality Inversion in Functional Self-Organized Helical Superstructures
Photoisomerizable chiral molecular switches or motors as guests induce chirality into achiral nematic liquid crystals and enable light-driven chirality inversion of the resulting cholesteric liquid crystals (CLCs). This Review describes the recent developments in the rational design of chiral guests with the capability for light-directed chirality inversion of CLCs.
Angew. Chem. Int. Ed. 10.1002/anie.201505520
Lei Sun, Michael G. Campbell, Mircea Dincă
Electrically Conductive Porous Metal–Organic Frameworks
MOFs conduct: Metal–organic frameworks (MOFs) that simultaneously display permanent porosity and electrical conductivity are an emerging class of materials that display promise for a wide variety of next-generation technologies. This Review describes recent progress in this rapidly developing field, with a focus on the design principles that have enabled long-range charge transport in MOFs.
Angew. Chem. Int. Ed. 10.1002/anie.201506219
Cosima Stubenrauch, Frank Gießelmann
Gelled Complex Fluids: Combining Unique Structures with Mechanical Stability
Going soft: Gelled complex fluids are soft materials in which the microstructure of the complex fluid is combined with the mechanical stability of a gel. This Review describes the structure and potential applications of such fluids and clarifies whether the respective system is formed through orthogonal self-assembly, that is, the independent but simultaneous formation of two coexisting self-assembled structures within one system.
Angew. Chem. Int. Ed. 10.1002/anie.201506603
Wei Xia, Asif Mahmood, Zibin Liang, Ruqiang Zou, Shaojun Guo
Earth-Abundant Nanomaterials for Oxygen Reduction
Pt free: Great efforts have been devoted to designing and optimizing earth-abundant nanomaterials for use as catalysts for the oxygen reduction reaction (ORR). These new catalysts have improved intrinsic catalytic activity, stability, and selectivity as well as performances nearing that of the classical platinum based catalysts. This Review highlights the recent breakthroughs in engineering non-Pt nanomaterials with advanced structures for enhanced ORR catalysis.
Angew. Chem. Int. Ed. 10.1002/anie.201504830