Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Reviews in Angewandte Chemie, written by leading experts, summarize the important results of recent research on topical subjects in all branches of chemistry, point to unresolved problems, and discuss possible developments. Although review articles are generally written upon invitation of the editor, unsolicited manuscripts are also welcome provided they are in keeping with the character of the journal.
Dr. Justus Masa, Dr. Wei Xia, Prof. Dr. Martin Muhler, Prof. Dr. Wolfgang Schuhmann
A free agent: Nitrogen-modified carbon (NC) materials (see scheme) are of emerging importance for electrocatalysis of the oxygen reduction reaction (ORR). However, trace-metal residues in NC catalysts can significantly influence the ORR, which has raised concerns regarding the validity of the notion of a metal-free catalyst. A critical discussion of the role of metals in NC catalysts is given to reconcile divergent views.
Structure-Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes
Dr. Marta Pelay-Gimeno, Adrian Glas, Dr. Oliver Koch, Dr. Tom N. Grossmann
A matter of class: Inhibitors of protein–protein interactions can be obtained by mimicking peptide binding epitopes in their bioactive conformation. For this purpose, several strategies have been evolved to yield molecules that are generally referred to as peptidomimetics. This Review highlights these approaches and introduces a new classification for peptidomimetics that enables a clear assignment of available approaches.
Dr. Li-Ming Yang, Prof. Eric Ganz, Prof. Zhongfang Chen, Prof. Zhi-Xiang Wang, Prof. Paul von Ragué Schleyer
Where the great plains begin: Planar hypercoordinate chemistry has emerged as an exciting field with the discovery of unique molecules with unusual bonding configurations. Starting with planar tetragonal carbon, molecules of increasing complexity and hypercoordinate bond number from four up to ten have been predicted, and some have been synthesized. This Review covers the evolution and rapid growth of the field of planar hypercoordinate chemistry over the last four and a half decades.
Dr. Emmanuel Roussakis, Dr. Zongxi Li, Dr. Alexander J. Nichols, Prof. Dr. Conor L. Evans
Tracking oxygen: To fully comprehend oxygen’s critical role in the biochemistry of life, various techniques have been developed for the measurement of its physiological tensions in different environments. There have been exciting advances in both instrumentation and method development, leading to techniques that are capable of providing oxygenation information from sub-cellular to macroscopic tissue levels (image: changes in oxygen consumption in a full-thickness burn).
Prof. Stephen T. Liddle
Rise like a phoenix? In the last several years, there has been a resurgence of non-aqueous uranium chemistry, in particular dealing with the development of new ligand classes and complexes with multiple bonding, single-molecule magnetism, and the activation of small molecules, such as N2, CO2, and alkanes. Owing to its unusual coordination properties, uranium is remarkably different from transition metals, but also from other actinides.
Dr. Quanjun Xiang, Prof. Bei Cheng, Prof. Jiaguo Yu
There’s always the sun: Graphene-based photocatalysts for solar-fuel production are of significant interest in solving the global energy problem. The recent advances in the fabrication and application of graphene-based photocatalysts, including photocatalytic reduction of CO2 to hydrocarbon fuels and photocatalytic splitting of water to H2 are explored.