Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Reviews in Angewandte Chemie, written by leading experts, summarize the important results of recent research on topical subjects in all branches of chemistry, point to unresolved problems, and discuss possible developments. Although review articles are generally written upon invitation of the editor, unsolicited manuscripts are also welcome provided they are in keeping with the character of the journal.
Francisco Fernandez-Trillo, Liam M. Grover, Alex Stephenson-Brown, Paul Harrison, Paula M. Mendes
Vesicles in Nature and the Laboratory: Elucidation of Their Biological Properties and Synthesis of Increasingly Complex Synthetic Vesicles
Inspiration–imitation–innovation: Parallel to the elucidation of the biological properties and physiological function of vesicles, increasingly elegant artificial vesicles are being reported. This Review provides an overview of the complex and rapidly developing fields of natural and synthetic vesicles and shows how the two fields can profit from one another.
Angew. Chem. Int. Ed. 10.1002/anie.201607825
Chia-I. Lin, Reid M. McCarty, Hung-wen Liu
The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems
Naming names: Chemical reactions that are named after their discoverers are known as “name reactions”. This Review is a collection of biological representatives of named chemical reactions. Emphasis is placed on reaction types and catalytic mechanisms that showcase both the chemical diversity in natural product biosynthesis as well as the parallels with synthetic organic chemistry.
Angew. Chem. Int. Ed. 10.1002/anie.201603291
Felipe Merino, Stefan Raunser
Electron Cryo-microscopy as a Tool for Structure-Based Drug Development
Cold as ice: A new generation of detectors has revolutionized electron cryo-microscopy (Cryo-EM). This review summarizes the use of cryo-EM to study the structure of pharmacologically relevant macromolecules that have escaped classical techniques. In many of these cases, drug-like molecules have been identified, thus validating cryo-EM as a useful tool for structure-based drug design.
Angew. Chem. Int. Ed. 10.1002/anie.201608432
Barry M. Trost, Michael C. Ryan
Indenylmetal Catalysis in Organic Synthesis
A fused relative: Indenyl ligands in many cases impart differential reactivity in transition-metal-catalyzed processes as compared to their well-developed cyclopentadienyl relatives. The advantages of such indenylmetal complexes for the synthesis of small molecules are summarized and highlighted.
Angew. Chem. Int. Ed. 10.1002/anie.201609054