Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 32

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie


Reviews in Angewandte Chemie, written by leading experts, summarize the important results of recent research on topical subjects in all branches of chemistry, point to unresolved problems, and discuss possible developments. Although review articles are generally written upon invitation of the editor, unsolicited manuscripts are also welcome provided they are in keeping with the character of the journal.

Index of Reviews: 1962–1969   1970–1979   1980–1989   1990–1999   2000–2009 2010–now  Nobel lectures


Chengxiang Xiang, Adam Z. Weber, Shane Ardo, Alan Berger, YiKai Chen, Robert Coridan, Katherine T. Fountaine, Sophia Haussener, Shu Hu, Rui Liu, Nathan S. Lewis, Miguel A. Modestino, Matthew M. Shaner, Meenesh R. Singh, John C. Stevens, Ke Sun, Karl Walczak
Modeling, Simulation, and Implementation of Solar-Driven Water-Splitting Devices

Modeling, Simulation, and Implementation of Solar‐Driven Water‐Splitting Devices

Catching the sun: Significant advances have been made in recent years on the modeling- and simulation-guided development of integrated solar-driven water-splitting devices. Multidimensional multiphysics models have provided design guidelines for semiconductors, electrocatalysts, as well as liquid and membrane electrolytes. This Review discusses the guiding principles and key findings of these activities.

Angew. Chem. Int. Ed. 10.1002/anie.201510463

Chuangang Hu, Liming Dai
Carbon-Based Metal-Free Catalysts for Electrocatalysis beyond the ORR

Carbon‐Based Metal‐Free Catalysts for Electrocatalysis beyond the ORR

Free agents: Carbon-based metal-free catalysts have been intensively researched as alternatives to noble-metal/metal oxide catalysts for the oxygen evolution reaction (OER) in metal–air batteries and for the splitting of water through the hydrogen evolution reaction (HER). This Review gives an overview of recent developments in this area, with a focus on the OER and HER.

Angew. Chem. Int. Ed. 10.1002/anie.201509982

J. Justin Gooding, Katharina Gaus
Single-Molecule Sensors: Challenges and Opportunities for Quantitative Analysis

Single‐Molecule Sensors: Challenges and Opportunities for Quantitative Analysis

More than the sum of its parts: Advances in measurement science have seen a progressive reduction in sample size to the point that single-molecule measurements are today commonplace. A new generation of sensors is expected that perform quantitative analysis by measuring many single-molecule events. This Review discusses the challenges, opportunities, and recent developments in quantitative single-molecule sensors.

Angew. Chem. Int. Ed. 10.1002/anie.201600495

Paul R. Wratil, Rüdiger Horstkorte, Werner Reutter
Metabolic Glycoengineering with N-Acyl Side Chain Modified Mannosamines

Metabolic Glycoengineering with N‐Acyl Side Chain Modified Mannosamines

Sugar for cells: Metabolic glycoengineering is a method to incorporate modified monosaccharides into cells, organs, or animals. Unnatural sialic acids can be generated by treatment with N-acyl side chain modified mannosamines. The application of this technique has intriguing biological consequences for treated cells. Mannosamine analogues bearing reactive groups can be used, for example, to visualize sialylated glycoconjugates.

Angew. Chem. Int. Ed. 10.1002/anie.201601123

Satoshi Ōmura
A Splendid Gift from the Earth: The Origins and Impact of the Avermectins (Nobel Lecture)

A Splendid Gift from the Earth: The Origins and Impact of the Avermectins (Nobel Lecture)

Japanese soil was the origin of one of the most important drugs of the world: ivermectin. No other drug has such importance for the health of millions of people, particularly in the poor regions of the world. The discovery of the parent compounds of the avermectines is described first hand by S. Ōmura.

Angew. Chem. Int. Ed. 10.1002/anie.201602164

Alexander P. Pulis, David J. Procter
C−H Coupling Reactions Directed by Sulfoxides: Teaching an Old Functional Group New Tricks

C−H Coupling Reactions Directed by Sulfoxides: Teaching an Old Functional Group New Tricks

Classical sulfoxide directing groups have been given a new lease on life because of their unique ability to direct a variety of C−H couplings to form important C−C bonds. Sulfoxide direction operates through internal coordination to a metal (directing groups), through external coordination (ligands), or via sulfoxide capture of nucleophilic or electrophilic coupling partners (sulfonium-directed).

Angew. Chem. Int. Ed. 10.1002/anie.201601540

Michael M. Lerch, Mickel J. Hansen, Gooitzen M. van Dam, Wiktor Szymanski, Ben L. Feringa
Emerging Targets in Photopharmacology

Emerging Targets in Photopharmacology

Spotlight on the patient: The impressive advances made in the field of photopharmacology in recent years are critically reviewed with respect to the “photodruggability” of medicinal targets and prospects of the selective delivery of light to different organs. This Review is meant to provide a stimulus for chemists to enter this exciting field, with fascinating opportunities to bring “smart” molecular design to the realm of clinical use.

Angew. Chem. Int. Ed. 10.1002/anie.201601931

Moisés Gulías, José Luis Mascareñas
Metal-Catalyzed Annulations through Activation and Cleavage of C−H Bonds

Metal‐Catalyzed Annulations through Activation and Cleavage of C−H Bonds

Formel notice: Recent years have witnessed an upsurge in annulations based on C−H activation that can be formally considered as cycloaddition processes. These transformations are particularly appealing from a synthetic perspective because they allow the conversion of readily available substrates into highly valuable cyclic products in a rapid and sustainable manner.

Angew. Chem. Int. Ed. 10.1002/anie.201511567

C. Rose Kennedy, Song Lin, Eric N. Jacobsen
The Cation–π Interaction in Small-Molecule Catalysis

The Cation–π Interaction in Small‐Molecule Catalysis

Positive effects: This Review discusses the burgeoning role of the cation–π interaction in the small-molecule catalysis of organic and organometallic reactions. An extensive survey of the state-of-the-art research emphasizes how unexpected discoveries and systematic mechanistic studies have begun to enable rational applications of the cation–π interaction in catalyst design.

Angew. Chem. Int. Ed. 10.1002/anie.201600547

William C. Campbell
Ivermectin: A Reflection on Simplicity (Nobel Lecture)

Ivermectin: A Reflection on Simplicity (Nobel Lecture)

Parasitic diseases including river blindness and lymphatic filariasis affect hundreds of millions of people annually. The discovery of the drug ivermectin has provided humankind with a powerful new means to combat these severe diseases. To a very large extent the drug was brought about by “simple” science.

Angew. Chem. Int. Ed. 10.1002/anie.201601492