Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Reviews in Angewandte Chemie, written by leading experts, summarize the important results of recent research on topical subjects in all branches of chemistry, point to unresolved problems, and discuss possible developments. Although review articles are generally written upon invitation of the editor, unsolicited manuscripts are also welcome provided they are in keeping with the character of the journal.
Santanu Mondal, Karuppusamy Raja, Ulrich Schweizer, Govindasamy Mugesh
Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones
A picture of health: Thyroid hormones are essential to control body metabolism, heart rate, neural development, as well as cardiovascular, renal, and brain functions. This Review discusses the chemistry and biology involved in the biosynthesis, plasma transport, metabolic pathways, and receptor-mediated action of thyroid hormones in relation to thyroid related disorders and their treatment.
Angew. Chem. Int. Ed. 10.1002/anie.201601116
The Intrinsic Fragility of DNA (Nobel Lecture)
Our cells contain common molecules, such as water or oxygen, that can damage DNA. In his studies Tomas Lindahl has shown how specific repair enzymes remove and replace damaged parts of DNA in a process of vital importance.
Angew. Chem. Int. Ed. 10.1002/anie.201602159
Yilin Hu, Markus W. Ribbe
Nitrogenases—A Tale of Carbon Atom(s)
A close rapport exists between nitrogenase and carbon through the interstitial carbide of the cofactor of nitrogenase and through the ability of nitrogenase to reduce small carbon compounds to hydrocarbons. Recent advances reveal a radical-SAM-dependent mechanism of carbide insertion into the nitrogenase cofactor and suggest a role of the interstitial carbide in maintaining the stability while permitting certain flexibility of the cofactor structure during catalysis.
Angew. Chem. Int. Ed. 10.1002/anie.201600010
DNA molecules are not completely stable, they are subject to chemical or photochemical damage and errors that occur during DNA replication resulting in mismatched base pairs. Through mechanistic studies Paul Modrich showed how replication errors are corrected by strand-directed mismatch repair in Escherichia coli and human cells.
Angew. Chem. Int. Ed. 10.1002/anie.201601412
Wolfgang G. Zeier, Alex Zevalkink, Zachary M. Gibbs, Geoffroy Hautier, Mercouri G. Kanatzidis, G. Jeffrey Snyder
Thinking Like a Chemist: Intuition in Thermoelectric Materials
Bonding interactions in thermoelectrics: Chemical bonding concepts and molecular orbital theory are used to understand electronic structures and the electronic and thermal transport in semiconductors. Emphasis is placed on the influence of local bonding interactions, such as bond length and orbital overlap, coordination environment, and the expression of lone-pairs.
Angew. Chem. Int. Ed. 10.1002/anie.201508381
Mathieu F. Chellat, Luka Raguž, Rainer Riedl
Targeting Antibiotic Resistance
No action today, no cure tomorrow: The development and spread of antibiotic resistance is a global threat to public health. After decades of declining interest in the development of new therapies against infections caused by pathogenic bacteria, a revitalization of antibiotic research has recently taken place. Structure-based and mechanism-based approaches, as well as interventions at the genetic level, hold great promise for conquering antibiotic resistance.
Angew. Chem. Int. Ed. 10.1002/anie.201506818
Todd K. Hyster, Thomas R. Ward
Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions
The second row also matters: In contrast to traditional transition-metal catalysts, artificial metalloenzymes can modulate both the first and second coordination spheres, and thus result in novel reactivities. This Review discusses attempts to modulate the second coordination sphere of artificial metalloenzymes through genetic modifications of the protein sequence.
Angew. Chem. Int. Ed. 10.1002/anie.201508816