Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 18

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Upcoming VIPs

The following papers are very important in the opinion of two referees.

You are invited to comment on published VIPs. Please use the link given at the end of each such abstract. Scientific comments may be forwarded to the authors by the editorial office and may be posted on this page. Kindly let us know if your comments are for the editorial office only, the author, or the public as well.

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One-Step Synthesis of [16]Helicene

Kazuyuki Mori, Dr. Takashi Murase and Prof. Dr. Makoto Fujita

One-Step Synthesis of [16]HeliceneAn aromatic spiral layer: A [16]helicene core was prepared in a single step by sextuple photocyclization from a single-strand arylene–vinylene precursor containing four phenylene and three naphthylene units linked by six vinylene spacers. X-ray crystallographic analysis revealed the triple-layered structure. A new guideline for the design of precursor olefins resulted in the longest helicene synthesized to date.

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A Planarized Triphenylborane Mesogen: Discotic Liquid Crystals with Ambipolar Charge-Carrier Transport Properties

Dr. Tomokatsu Kushida, Ayumi Shuto, Prof. Dr. Masafumi Yoshio, Prof. Dr. Takashi Kato and Prof. Dr. Shigehiro Yamaguchi

A Planarized Triphenylborane Mesogen: Discotic Liquid Crystals with Ambipolar Charge-Carrier Transport PropertiesB planar, B aligned: A planarized triphenylborane, bearing three 3,4,5-tridodecyloxyphenyl groups, forms a hexagonal columnar liquid-crystalline phase at ambient temperature. It has a columnar π-stacked structure and ambipolar carrier-transport properties with hole- and electron-mobility values of 3×10−5 cm2 V−1 s−1 and approximately 10−3 cm2 V−1 s−1, respectively.

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High-Fidelity Noncovalent Synthesis of Hydrogen-Bonded Macrocyclic Assemblies

Carlos Montoro-García, Jorge Camacho-García, Dr. Ana M. López-Pérez, Nerea Bilbao, Sonia Romero-Pérez, Dr. María J. Mayoral and Dr. David González-Rodríguez

High-Fidelity Noncovalent Synthesis of Hydrogen-Bonded Macrocyclic AssembliesFine design of a dinucleoside monomer leads to hydrogen-bonded macrocyclic tetramer assemblies with high effective molarities and remarkable thermodynamic and kinetic stability. The behavior of these assemblies in various solvents is discussed.

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Responsive Inverse Opal Hydrogels for the Sensing of Macromolecules

Ing. Jean-Philippe Couturier, Dr. Martin Sütterlin, Prof. Dr. André Laschewsky, Dr. Cornelia Hettrich and Dr. Erik Wischerhoff

Responsive Inverse Opal Hydrogels for the Sensing of MacromoleculesA successful marriage: The combination of smart hydrogels and inverse opal structures unites simplicity with efficacy for sensing macromolecules. While the inverse opal structure provides structural color and a large accessible interface for binding, the induced phase transition of the analyte-responsive hydrogel produces strong optical effects. The resulting spectral shifts can surpass 100 nm and are easily detected.

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Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

Daniel Yuan Qiang Wong, Wendy Wei Fang Ong and Prof. Wee Han Ang

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum ComplexesFor the long run: Some chemotherapeutics can activate a long-term immune-mediated response against cancer by triggering an immunogenic mode of cancer cell death (ICD). A library of platinum complexes were studied, and a potent Pt-based ICD inducer was thus identified.

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Biomimetic Total Synthesis of Santalin Y

Dr. Sebastian Strych, Dr. Guillaume Journot, Ryan P. Pemberton, Dr. Selina C. Wang, Prof. Dr. Dean J. Tantillo and Prof. Dr. Dirk Trauner

Biomimetic Total Synthesis of Santalin YHigh five! The five stereocenters of santalin Y, a complex yet racemic natural product, were installed in a single operation. Quantum chemical computations point to a concerted 1,3-dipolar cycloaddition that involves a “vinylogous oxidopyrylium species” as the key step.

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Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered

Prof. Jamshed Anwar, Dr. Shahzeb Khan and Prof. Dr. Lennart Lindfors

Secondary Crystal Nucleation: Nuclei Breeding Factory UncoveredCrystal clear: Molecular dynamics simulations uncover the nuclei breeding factory responsible for secondary nucleation in crystal growth. The question why a few crystal seeds give rise to a many-fold increase in new crystals is answered. This mechanistic insight will enable better control in engineering crystalline products to design.

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Structural Transformation: Assembly of an Otherwise Inaccessible DNA Nanocage

Dr. Yulin Li, Dr. Cheng Tian, Zhiyu Liu, Prof. Wen Jiang and Prof. Chengde Mao

Structural Transformation: Assembly of an Otherwise Inaccessible DNA NanocageOne way or another: A strategy has been developed for the assembly of DNA nanocages that can not be assembled directly. In this approach a precursor DNA nanocage is assembled first and is then isothermally transformed into a desired, complicated nanocage. Dramatic changes in the 3D structures and topologies accompany the transformation, as shown by native polyacrylamide gel electrophoresis and cryogenic electron microscopy imaging.

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Origin of Extraordinary Stability of Square-Planar Carbon Atoms in Surface Carbides of Cobalt and Nickel

Anjan Nandula, Quang Thang Trinh, Prof. Mark Saeys and Prof. Anastassia N. Alexandrova

Origin of Extraordinary Stability of Square-Planar Carbon Atoms in Surface Carbides of Cobalt and NickelOut for the count: The unusual stability and reconstruction of surface cobalt and nickel carbides containing square-planar carbon atoms is explained by local aromaticity and electron count. A chemical bonding model for these systems is presented and explains the unusual structure, special stability, and the reconstruction. Several new aromatic and stable two-dimensional alloys are predicted.

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A Unique Fluoride Nanocontainer: Porous Molecular Capsules Can Accommodate an Unusually High Number of “Rather Labile” Fluoride Anions

Somenath Garai, Dr. Mirta Rubčić, Dr. Hartmut Bögge, Dr. Erhard T. K. Haupt, Prof. Dr. Pierre Gouzerh and Prof. Dr. Achim Müller

A Unique Fluoride Nanocontainer: Porous Molecular Capsules Can Accommodate an Unusually High Number of “Rather Labile” Fluoride AnionsOverloaded: Porous molecular nanocontainers of the {Mo132} Keplerate type can integrate a uniquely large number of fluorides. These F ions (see structure, green) are partly as coordinated ligands at both the {(MoVI)MoVI5O21(H2O)5(F)} pentagonal units (orange) and the linkers (blue), partly as a disordered water/fluoride assembly inside the cavity. The H2O ligands are shown as red spheres (larger red spheres are for H2O coordinated e.g. to the MoV centers of the linkers).

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A Constellation of Deuterium-Labeled Silanes as a Simple Mechanistic Probe not Requiring Absolute Configuration Determination

Dr. Thomas Fallon and Prof. Dr. Martin Oestreich

A Constellation of Deuterium-Labeled Silanes as a Simple Mechanistic Probe not Requiring Absolute Configuration DeterminationSilicon stargazing: A new type of mechanistic probe is designed and evaluated. A cocktail of deuterium-labeled hydrosilanes provides a “silent” stereochemical relationship between the silicon atom and the probe’s backbone as the basis of the analysis. This technique does not suffer from the biases of traditional methods, nor does it require the determination of the absolute configuration.

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Improving the Electrochemical Performance of the Li4Ti5O12 Electrode in a Rechargeable Magnesium Battery by Lithium–Magnesium Co-Intercalation

Na Wu, Zhen-Zhong Yang, Hu-Rong Yao, Dr. Ya-Xia Yin, Prof. Lin Gu and Prof. Yu-Guo Guo

Improving the Electrochemical Performance of the Li4Ti5O12 Electrode in a Rechargeable Magnesium Battery by Lithium–Magnesium Co-IntercalationSynergy between Mg2+ and Li+ ions: By controlling the collaborative electrochemistry of magnesium and lithium cations, Li4Ti5O12 electrodes (LTO; see picture) close to sub-micron size gain extraordinary electrochemical energy storage capability. The electrodes show improved kinetics in rechargeable magnesium batteries.

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Direct C(sp2)[BOND]C(sp3) Cross-Coupling of Diaryl Zinc Reagents with Benzylic, Primary, Secondary, and Tertiary Alkyl Halides

Dr. Jay J. Dunsford, Dr. Ewan R. Clark and Dr. Michael J. Ingleson

Direct C(sp2)<img src="http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif" alt="[BOND]" />C(sp3) Cross-Coupling of Diaryl Zinc Reagents with Benzylic, Primary, Secondary, and Tertiary Alkyl HalidesZinc and you’ll miss it! Direct C(sp2)[BOND]C(sp3) cross-coupling of diaryl zinc reagents with alkyl halides proceeded rapidly at ambient temperature without a coordinating ethereal solvent or an added catalyst (see scheme). This versatile, operationally simple approach to C(sp2)[BOND]C(sp3) bond formation enables the expedient construction of a diverse array of carbon-based structural motifs.

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