Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 5

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Upcoming VIPs

The following papers are very important in the opinion of two referees.

You are invited to comment on published VIPs. Please use the link given at the end of each such abstract. Scientific comments may be forwarded to the authors by the editorial office and may be posted on this page. Kindly let us know if your comments are for the editorial office only, the author, or the public as well.

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A Carbon–Air Battery for High Power Generation

Binbin Yang, Prof. Ran Ran, Yijun Zhong, Dr. Chao Su, Prof. Moses O. Tadé and Prof. Zongping Shao

A Carbon–Air Battery for High Power GenerationMidair refueling: A carbon–air battery based on a anode-supported tubular solid-oxide fuel cell integrated with a CO2 separation membrane (see picture) composed of a CO32− mixture and an O2− conducting phase showed both high energy density and power output. A small stack composed of two batteries can be operated continuously for 200 min, which is promising for use as a portable power device.

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Remarkably Enhanced Gas Separation by Partial Self-Conversion of a Laminated Membrane to Metal–Organic Frameworks

Dr. Yi Liu, Dr. Jia Hong Pan, Nanyi Wang, Frank Steinbach, Dr. Xinlei Liu and Prof. Jürgen Caro

Remarkably Enhanced Gas Separation by Partial Self-Conversion of a Laminated Membrane to Metal–Organic FrameworksFrom LDH to MOF: The partial transformation of a ZnAl-NO3 layered double hydroxide (LDH) membrane to a ZIF-8 metal–organic framework (MOF) top layer led to the formation of the composite membrane ZIF-8-ZnAl-NO3 LDH. This membrane is characterized by remarkably enhanced H2/CH4 gas separation and H2 permeance.

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Lithium Imide Synergy with 3d Transition-Metal Nitrides Leading to Unprecedented Catalytic Activities for Ammonia Decomposition

Jianping Guo, Peikun Wang, Prof. Dr. Guotao Wu, Prof. Dr. Anan Wu, Daqiang Hu, Prof. Dr. Zhitao Xiong, Prof. Dr. Junhu Wang, Pei Yu, Fei Chang, Zheng Chen and Prof. Dr. Ping Chen

Lithium Imide Synergy with 3d Transition-Metal Nitrides Leading to Unprecedented Catalytic Activities for Ammonia DecompositionBeyond an electronic promoter: A synergy between Li2NH and 3d transition-metal nitrides leads to unprecedented catalytic activities for NH3 decomposition. Li2NH acts as more than just an electronic promoter: it is an NH3 transmitting agent and favors the formation of a higher N-content intermediate, thereby altering the overall reaction energetics.

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A D-Peptide Ligand of Nicotine Acetylcholine Receptors for Brain-Targeted Drug Delivery

Xiaoli Wei, Dr. Changyou Zhan, Qing Shen, Prof. Wei Fu, Cao Xie, Jie Gao, Chunmei Peng, Prof. Ping Zheng and Prof. Weiyue Lu

A <span class="smallCaps">D</span>-Peptide Ligand of Nicotine Acetylcholine Receptors for Brain-Targeted Drug DeliveryA D-peptide ligand of nicotine acetylcholine receptors (nAChRs), termed DCDX, was developed. The function of DCDX as a D-peptide antagonist of nAChRs was experimentally and computationally validated. DCDX exhibits exceptional stability during nAChRs-mediated transcytosis and in blood circulation, offering potential for brain-targeting drug delivery in the treatment of central nervous system diseases.

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Synergistic Interplay of a Non-Heme Iron Catalyst and Amino Acid Coligands in H2O2 Activation for Asymmetric Epoxidation of α-Alkyl-Substituted Styrenes

Olaf Cussó, Dr. Xavi Ribas, Dr. Julio Lloret-Fillol and Dr. Miquel Costas

Synergistic Interplay of a Non-Heme Iron Catalyst and Amino Acid Coligands in H2O2 Activation for Asymmetric Epoxidation of α-Alkyl-Substituted StyrenesCome on styrene: Using amino acids as coligands for bioinspired non-heme iron catalysts, the substrate scope of epoxidation reactions with aqueous H2O2 is extended to the challenging α-styrenes. Thus, these systems can be adapted for new substrates classes simple by changing the amino acid coligand.

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Electron Tunneling Rates in Respiratory Complex I Are Tuned for Efficient Energy Conversion

Prof. Dr. Simon de Vries, Dr. Katerina Dörner, Marc J. F. Strampraad and Prof. Dr. Thorsten Friedrich

Electron Tunneling Rates in Respiratory Complex I Are Tuned for Efficient Energy ConversionThe reduction of ubiquinone by NADH is catalyzed by flavin mononucleotide and a chain of seven iron–sulfur centers. The electron transfer rates between the centers indicate that the Fe–S chain synchronizes the electron transfer rate to match the time scale of the conformational changes required for proton translocation.

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Tetracyclopenta[def,jkl,pqr,vwx]tetraphenylene: A Potential Tetraradicaloid Hydrocarbon

Dr. Shunpei Nobusue, Hirokazu Miyoshi, Dr. Akihiro Shimizu, Dr. Ichiro Hisaki, Kotaro Fukuda, Prof. Masayoshi Nakano and Prof. Yoshito Tobe

Tetracyclopenta[def,jkl,pqr,vwx]tetraphenylene: A Potential Tetraradicaloid HydrocarbonAromatic? A tetramesityl derivative of hitherto unknown tetracyclopenta[def,jkl,pqr,vwx]tetraphenylene, a potential tetraradicaloid hydrocarbon, was synthesized. It exhibits remarkable antiaromaticity as a result of the peripheral 20-π-electron circuit. In solution, it adopts closed-shell D2h structures that rapidly equilibrate via the D4h structure, and in crystals, it adopts an approximate D2h structure.

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Controlling the Subtle Energy Balance in Protic Ionic Liquids: Dispersion Forces Compete with Hydrogen Bonds

Dr. Koichi Fumino, M. Sc. Verlaine Fossog, B. Sc. Peter Stange, Dr. Dietmar Paschek, Prof. Dr. Rolf Hempelmann and Prof. Dr. Ralf Ludwig

Controlling the Subtle Energy Balance in Protic Ionic Liquids: Dispersion Forces Compete with Hydrogen BondsThe winner is … Dispersion forces compete with hydrogen bonds in a protic ionic liquid. The energy balance can be controlled by the hydrogen-bond interaction strength of the anion and the alkyl-chain lengths of the cation. The energy of conversion between the H-bonded and the dispersion-dominated ion pairs can be determined experimentally by far-infrared spectroscopy. Dispersion-corrected DFT methods are essential for reproducing the experimental results.

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Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole Alkaloids

Dr. Hsiao-Ching Lin, Dr. Grace Chiou, Dr. Yit-Heng Chooi, Dr. Travis C. McMahon, Dr. Wei Xu, Prof. Neil K. Garg and Prof. Yi Tang

Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole AlkaloidsPutting the whole family on the map: Communesins, a prominent class of complex indole alkaloids isolated from various Penicillium species, are shown to be biosynthesized from two different building blocks derived from L-tryptophan. The entire biosynthetic pathway was mapped by genetic inactivation studies, which led to the isolation of three new communesin analogues.

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Rational Design of a Humanized Glucagon-Like Peptide-1 Receptor Agonist Antibody

Dr. Yong Zhang, Dr. Huafei Zou, Dr. Ying Wang, Dawna Caballero, Jose Gonzalez, Elizabeth Chao, Gus Welzel, Dr. Weijun Shen, Dr. Danling Wang, Dr. Peter G. Schultz and Dr. Feng Wang

Rational Design of a Humanized Glucagon-Like Peptide-1 Receptor Agonist AntibodyA humanized glucagon-like peptide-1 receptor agonist antibody was generated through genetic fusion of the exendin-4 peptide into CDR3H of the humanized monoclonal antibody herceptin with a heterodimeric coiled-coil “stalk”. The resulting clipped herceptin–Ex-4 fusion protein shows excellent biological and pharmacological properties.

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Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection

Meihua Lin, Jingjing Wang, Guobao Zhou, Jianbang Wang, Na Wu, Prof. Jianxin Lu, Prof. Jimin Gao, Prof. Xiaoqing Chen, Dr. Jiye Shi, Prof. Xiaolei Zuo and Prof. Chunhai Fan

Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA DetectionSelf-assembled DNA nanostructures with precise sizes allowed a programmable “soft lithography” approach to engineer the interfaces of electrochemical DNA sensors. Using millimeter-sized gold electrodes modified with several types of tetrahedral DNA nanostructures of different sizes, it was shown that both the kinetics and thermodynamics of DNA hybridization were profoundly affected.

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Crystalline Stereocomplexed Polycarbonates: Hydrogen-Bond-Driven Interlocked Orderly Assembly of the Opposite Enantiomers

Dr. Ye Liu, Wei-Min Ren, Meng Wang, Chuang Liu and Prof. Dr. Xiao-Bing Lu

Crystalline Stereocomplexed Polycarbonates: Hydrogen-Bond-Driven Interlocked Orderly Assembly of the Opposite EnantiomersMixed tactics: Mixing of crystalline or amorphous isotactic (R)- and (S)-polycarbonates affords crystalline stereocomplexed polymers which have a high melting temperature of up to 300 °C, and provides higher thermal properties for CO2-based polycarbonate materials.

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