Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
The following papers are very important in the opinion of two referees.
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Insertion Homo- and Copolymerization of Diallyl Ether
Dr. Zhongbao Jian and Prof. Dr. Stefan Mecking
Di-allyl versus mono-allyl monomer: Diallyl ether as a monomer allows for an unprecedented incorporation (20 mol %) and enhanced activity of an allyl monomer in insertion copolymerizations. Even homopolymerization of diallyl ether is possible, thereby yielding poly(diallyl ether) with degrees of polymerization of DPn≈44, which has previously been difficult for allyl monomers by any polymerization mechanism.
Glycocalyx Engineering with a Recycling Glycopolymer that Increases Cell Survival In Vivo
Elliot C. Woods, Nathan A. Yee, Jeff Shen and Prof. Carolyn R. Bertozzi
Keepin’ it sweet! A panel of glycopolymers bearing a variety of lipids were used to identify constructs that persist on cell membranes. Cholesterylamine-anchored glycopolymers are internalized but recycle to allow for the continuous display of cell-surface glycopolymers for ten days. Furthermore, these mimetics enhance the survival of nonmalignant cells in a zebrafish model of metastasis.
A Filled-Honeycomb-Structured Crystal Formed by Self-Assembly of a Janus Polyoxometalate–Silsesquioxane (POM–POSS) Co-Cluster
Chi Ma, Han Wu, Zi-Han Huang, Dr. Ruo-Hai Guo, Dr. Min-Biao Hu, Dr. Christian Kübel, Prof. Dr. Li-Tang Yan and Prof. Dr. Wei Wang
How to pack dumbbells: The size asymmetry and Janus characteristics of a dumbbell-shaped co-cluster synergistically define its self-assembly in solution into crystals with a filled-honeycomb superstructure. The Janus co-cluster consists of a POM (purple sphere) and a POSS (green sphere) linked by an organic tether.
Polyboramines for Hydrogen Release: Polymers Containing Lewis Pairs in their Backbone
Audrey Ledoux, Dr. Paolo Larini, Dr. Christophe Boisson, Dr. Vincent Monteil, Dr. Jean Raynaud and Dr. Emmanuel Lacôte
Polybor-a-mine of H2: The one-step polycondensation of diamine and diborane precursors leads to polymer chains assembled by multiple Lewis pairs (see scheme). The new polyboramines are dihydrogen reservoirs that can hydrogenate imines, aldehydes, and ketones. The polyboramines release H2 thermally with a unique profile, which is a direct consequence of the polymeric nature of the material.
Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging
Yijing Liu, Dr. Jie He, Kuikun Yang, Dr. Chenglin Yi, Dr. Yi Liu, Dr. Liming Nie, Prof. Niveen M. Khashab, Dr. Xiaoyuan Chen and Prof. Zhihong Nie
Chain vesicles: Hollow plasmonic vesicles were obtained by the folding up of gold nanoparticle strings. The strong absorption of the chain vesicles in the near-infrared (NIR) region enables their application as contrast agents in photoacoustic imaging and as drug-delivery vehicles with NIR light triggered drug release.
A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis
Dr. Lauren Ray, Dr. Kazuya Yamanaka and Prof. Dr. Bradley S. Moore
Uncovering the biosynthesis of salinamide A has illuminated a type I thioesterase that plays a pivotal role in the installation of an acylglycine handle across the relatively simple hexadepsipeptide core in an unprecedented intermolecular peptidyl transesterification. The enzyme catalyzes the transfer of an acylated glycine from a carrier protein (CP) to a serine hydroxy group within the offloaded non-ribosomal peptide product.
Energy-Level Alignment for Single-Molecule Conductance of Extended Metal-Atom Chains
Ta-Cheng Ting, Dr. Liang-Yan Hsu, Dr. Min-Jie Huang, Er-Chien Horng, Dr. Hao-Cheng Lu, Chan-Hsiang Hsu, Dr. Ching-Hong Jiang, Prof. Bih-Yaw Jin, Prof. Shie-Ming Peng and Prof. Chun-hsien Chen
Gating the current flow: The transmission efficiency of electron transport across molecular junctions can be controlled electrochemically by potentiostatting the electrode Fermi level (EF) to be close to the frontier orbitals (EFMO) of the bridging molecule. Transition voltage spectroscopy was utilized to extract quantitative information on the barrier height between EF and EFMO.
The Triboracyclopropenyl Dianion: The Lightest Possible Main-Group-Element Hückel π Aromatic
Dr. Thomas Kupfer, Prof. Dr. Holger Braunschweig and Dr. Krzysztof Radacki
Chemical reduction of Cl2BNCy2 afforded Na4[B3(NCy2)3]2⋅2 DME, which contains the triboracyclopropenyl dianion [B3(NCy2)3]2−, a boron-based analogue of the prototypical Hückel 2π aromatic [C3H3]+. Both X-ray diffraction and density functional theory are indicative of BB multiple bonding and the presence of a cyclically delocalized 2π electron system.
Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′-5′ Linkages
Dr. Christopher Cozens, Dr. Hannes Mutschler, Geoffrey M. Nelson, Dr. Gillian Houlihan, Dr. Alexander I. Taylor and Dr. Philipp Holliger
Specific distortion: A novel engineered polymerase can synthesize both DNA and RNA with regioisomeric 2′-5′ backbone linkages. It forms the basis for position-selective incorporation of 2′-5′ linkages enabling “structural mutagenesis”. As a result structure, conformation, duplex stability, and activity of nucleic acids may be probed through the site-specific insertion of regioisomeric backbone distortions.
Intermolecular Interactions and Protein Dynamics by Solid-State NMR Spectroscopy
Jonathan M. Lamley, Carl Öster, Rebecca A. Stevens and Dr. Józef R. Lewandowski
Protein dynamics: To investigate the influence of different intermolecular interactions on the protein dynamics extensive widespread site-specific 15N relaxation measurements were compared for a protein GB1 in a crystal and in an antibody complex with a molecular weight of more than 300 kDa (see picture). The proposed approach allows to directly access dynamics of a protein in large protein complexes.
Solid-State Chemistry on the Nanoscale: Ion Transport through Interstitial Sites or Vacancies?
Dr. Cornelia Bothe, Andreas Kornowski, Hans Tornatzky, Dr. Christian Schmidtke, Prof. Dr. Holger Lange, Prof. Dr. Janina Maultzsch and Prof. Dr. Horst Weller
Lead astray: Ion exchange and transport in nanocrystals is studied on the molecular scale. The cation exchange from PbSe with Cd2+ showed that the exchange occurred exclusively by diffusion via the interstitial sites and subsequent expulsion of individual ions from lattice sites without the formation of vacancies.
De Novo Fragment Design for Drug Discovery and Chemical Biology
Dr. Tiago Rodrigues, Daniel Reker, Dr. Martin Welin, Michael Caldera, Cyrill Brunner, Gisela Gabernet, Dr. Petra Schneider, Prof. Dr. Björn Walse and Prof. Dr. Gisbert Schneider
Automated computational molecular design generated a fragment-sized inhibitor of death-associated protein kinase 3, which was confirmed by X-ray crystallography of the kinase–inhibitor complex. Target prediction software identified additional macromolecular targets of the designed compound and the structurally closely related drug azosemide.