Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 52

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Upcoming VIPs

The following papers are very important in the opinion of two referees.

You are invited to comment on published VIPs. Please use the link given at the end of each such abstract. Scientific comments may be forwarded to the authors by the editorial office and may be posted on this page. Kindly let us know if your comments are for the editorial office only, the author, or the public as well.

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Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

Dr. Sascha Baumann, Dr. Jennifer Herrmann, Dr. Ritesh Raju, Dipl.-Ing. Heinrich Steinmetz, Dr. Kathrin I. Mohr, Dr. Stephan Hüttel, Dr. Kirsten Harmrolfs, Prof. Dr. Marc Stadler and Prof. Dr. Rolf Müller

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial ActivityAgainst multidrug resistance: A novel chemical scaffold with very pronounced activity against bacterial topoisomerases has been isolated from myxobacteria. Cystobactamid 919-2, as the most active derivative, is a potent antibacterial agent against numerous pathogens, including some Gram-negative species, such as E. coli and A. baumannii (see Scheme; rel and SC denote relaxed and supercoiled E. coli DNA, respectively).

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CO-Extrusion in Homogeneous Gold Catalysis: Reactivity of Gold Acyl Species Generated through Water Addition to Gold Vinylidenes

M. Sc. Janina Bucher, B. Sc. Tim Stößer, Dr. Matthias Rudolph, Dr. Frank Rominger and Prof. Dr. A. Stephen K. Hashmi

CO-Extrusion in Homogeneous Gold Catalysis: Reactivity of Gold Acyl Species Generated through Water Addition to Gold VinylidenesGold acyl intermediates are generated through the addition of water to gold vinylidene intermediates. The hitherto barely known gold acyl species are shown to undergo an extrusion of CO, an elementary step so far unknown in homogeneous gold catalysis. The reaction sequence constitutes a new gold-catalyzed decarbonylative indene synthesis.

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Total Synthesis of Albicidin: A Lead Structure from Xanthomonas albilineans for Potent Antibacterial Gyrase Inhibitors

Julian Kretz, Dennis Kerwat, Vivien Schubert, Stefan Grätz, Alexander Pesic, Siamak Semsary, Stéphane Cociancich, Monique Royer and Prof. Dr. Roderich D. Süssmuth

Total Synthesis of Albicidin: A Lead Structure from Xanthomonas albilineans for Potent Antibacterial Gyrase Inhibitors New antibiotics are urgently needed in view of bacterial resistance to established drugs. Albicidin shows activity against various Gram-negative and Gram-positive bacteria, thus making it a promising lead candidate for drug development. The first total synthesis of albicidin was achieved through a convergent synthetic approach that is applicable to the production of derivatives for structure–activity studies.

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Emulsion Ripening through Molecular Exchange at Droplet Contacts

Dr. Kevin Roger, Prof. Dr. Ulf Olsson, Dr. Ralf Schweins and Dr. Bernard Cabane

Emulsion Ripening through Molecular Exchange at Droplet ContactsAnother pathway for coarsening of emulsion is uncovered, besides coalescence and Ostwald ripening, that is termed contact ripening (top). Its mechanism consists in an exchange of oil molecules during collisions of droplets (middle). The key step is the synchronous thinning of each surfactant layer, through which oil molecules can cross the interface (bottom).

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One-pot Synthesis of CdS Nanocrystals Hybridized with Single-Layer Transition-Metal Dichalcogenide Nanosheets for Efficient Photocatalytic Hydrogen Evolution

Junze Chen, Dr. Xue-Jun Wu, Lisha Yin, Dr. Bing Li, Dr. Xun Hong, Zhanxi Fan, Bo Chen, Prof. Can Xue and Prof. Hua Zhang

One-pot Synthesis of CdS Nanocrystals Hybridized with Single-Layer Transition-Metal Dichalcogenide Nanosheets for Efficient Photocatalytic Hydrogen EvolutionA single layer makes the difference: MS2–CdS (M=W or Mo) nanohybrids with single-layer MS2 nanosheets selectively grown on the Cd-rich (0001) surface of wurtzite CdS nanocrystals (see picture) are synthesized by a facile one-pot wet-chemical method. The MS2–CdS nanohybrids showed excellent photocatalytic activity towards the hydrogen evolution reaction and good stability.

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Short, Enantioselective Total Synthesis of Chatancin

Dr. Yu-Ming Zhao and Prof. Dr. Thomas J. Maimone

Short, Enantioselective Total Synthesis of ChatancinNew orchestration: The synthetic route to the polycyclic diterpene (+)-chatancin does not rely on a macrocyclization step, avoids protecting-group manipulations, and appears to be suitable for the straightforward construction of analogues. Adaptations to the general strategy should serve in synthesis of other cembrane-derived natural products.

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Quantitative Trace Analysis of Complex Mixtures Using SABRE Hyperpolarization

Nan Eshuis, Bram J. A. van Weerdenburg, Dr. Martin C. Feiters, Prof. Dr. Floris P. J. T. Rutjes, Prof. Dr. Sybren S. Wijmenga and Dr. Marco Tessari

Quantitative Trace Analysis of Complex Mixtures Using SABRE HyperpolarizationQuantitative trace analysis: Nuclear spin hyperpolarization of small molecules in complex mixtures is achieved by signal amplification by reversible exchange (SABRE). The resulting signal enhancements allow quantification of compounds present at low micromolar concentrations in a few single-scan NMR experiments.

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Solution-Grown Organic Single-Crystalline Donor–Acceptor Heterojunctions for Photovoltaics

Prof. Hanying Li, Congcheng Fan, Weifei Fu, Dr. Huolin L. Xin and Prof. Hongzheng Chen

Solution-Grown Organic Single-Crystalline Donor–Acceptor Heterojunctions for PhotovoltaicsIdeal candidates for high-performance photovoltaics, organic single-crystalline heterojunctions are difficult to prepare. Now, extended single-crystalline heterojunctions with consistent donor-top and acceptor-bottom structure throughout the substrate can be obtained from a mixed solution of donor and acceptor through sequential crystallization. These heterojunctions exhibit a significant photovoltaic effect.

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Half-Metallicity in Single-Layered Manganese Dioxide Nanosheets by Defect Engineering

Hui Wang, Jiajia Zhang, Xudong Hang, Dr. Xiaodong Zhang, Dr. Junfeng Xie, Prof. Bicai Pan and Prof. Yi Xie

Half-Metallicity in Single-Layered Manganese Dioxide Nanosheets by Defect EngineeringA manganese dioxide monolayer was rendered half-metallic by a defect engineering strategy, which was confirmed by calculations. These theoretical studies showed that the half-metallicity of a single-layered MnO2 nanosheet can be observed for a wide range of vacancy concentrations and even in the presence of both Mn and O vacancies.

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Stereocomplexed Poly(Limonene Carbonate): A Unique Example of the Cocrystallization of Amorphous Enantiomeric Polymers

Prof. Finizia Auriemma, Prof. Claudio De Rosa, Dr. Maria Rosaria Di Caprio, Dr. Rocco Di Girolamo, Dr. W. Chadwick Ellis and Prof. Geoffrey W. Coates

Stereocomplexed Poly(Limonene Carbonate): A Unique Example of the Cocrystallization of Amorphous Enantiomeric PolymersWhen life gives you lemons, make a stereocomplex! Enantiomerically pure isotactic poly(limonene carbonate), derived from citrus oil and CO2, is an amorphous polymeric material in spite of its regular constitution and configuration. However, upon mixing together both enantiomers, a “zippering” interaction between chains of opposite configuration occurs, resulting in an overall semi-crystalline ensemble.

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Magnet Design by Integration of Layer and Chain Magnetic Systems in a π-Stacked Pillared Layer Framework

Hiroki Fukunaga and Prof. Dr. Hitoshi Miyasaka

Magnet Design by Integration of Layer and Chain Magnetic Systems in a π-Stacked Pillared Layer FrameworkA pillared layer framework (PLF) was used to rationally design and fabricate a long-range ordered magnet with a phase transition temperature (Tc) of 82 K by integrating two low-dimensional magnetic materials, namely a layer magnetic system and a one-dimensional columnar magnetic system. Furthermore, Tc increased linearly with the applied pressure.

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An Efficient Nanoscale Heterogeneous Catalyst for the Capture and Conversion of Carbon Dioxide at Ambient Pressure

Xiao-Huan Liu, Dr. Jian-Gong Ma, Dr. Zheng Niu, Prof. Dr. Guang-Ming Yang and Prof. Dr. Peng Cheng

An Efficient Nanoscale Heterogeneous Catalyst for the Capture and Conversion of Carbon Dioxide at Ambient PressureSilver nanoparticles were supported on the zeolite-type metal–organic framework MIL-101 by a simple liquid impregnation method to yield Ag@MIL-101. CO2 and terminal alkynes could be converted into propiolic acids in the presence of the very active Ag@MIL-101 catalyst at atmospheric pressure and low temperature (50 °C).

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