Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. Engl. 6/1984)
The cover shows schematically the structure of the d1, -domain of lactate dehydrogenase in the native state. In NAD-dependent dehydrogenases, many amino acids can be exchanged without causing a drastic change in the tertiary structure (“degenerate folding code”). Furthermore, only a limited number of amino acids appear to exist which form a well-defined, stable tertiary structure. These two discoveries provide an explanation for the surprisingly small number of “folding topologies” which are found in the greater number of known structures.—For more information see the article by R. Jaenicke on page 395ff.