Angewandte Chemie International Edition
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. Engl. 2/1985)
The cover page shows a stereograph of the structure of cyclosporine. This natural cyclopeptide contains a novel amino acid, a threonine derivative with a butenyl group which quasi bridges the ring. This amino acid is essential for the immunosuppressive activity of cyclosporine. More about the structure-activity relationships and about the synthesis of cyclosporine and analogues are reported by R. M. Wenger in a review article on page 17.—An optimal picture of the spatial architecture of the molecule is obtained if the stereograph is viewed through a mirror stereoscope; the three-dimensional structure in Figure 2 on page 79 can be seen quite readily with the aid of a lens stereoscope or even with the naked eye.