Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. Engl. 5/1989)
The cover illustration shows the computer-aided design of an artificial protein exhibiting a six-helix bundle structure. The molecule represents a typical candidate of a “Template-Assembled Synthetic Protein” (TASP) and was designed as a membrane channel forming protein (K. Gubernator, M. Mutter). The TASP strategy for the construction of new proteins aims to bypass the folding problem encountered in todays protein de novo design by template-directed assembly of peptide chains to a well-defined packing arrangement (in the depicted example, the template is a cyclic 12-amino acid peptide (blue), the six helices in red, orange and magenta are covalently attached via the lysine side chains of the template). In the light of our recent understanding of protein folding, Mutter and Vuilleumier discuss the foundations and prospects of this protein design by chemical tools on pages 535 ff.