Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. Engl. 9/1990)
The cover picture shows the simulated approach of “golfomycin”, a low-molecular-weight synthetic compound, to double-stranded DNA. Golfomycin, a cyclodecadiynone derivative, was designed to cleave DNA via a diradical mechanism. Although the actual mechanism was different from that expected, golf-omycin indeed cleaved DNA and proved to be cytotoxic (in vitro). The design, synthesis, and testing of golfomycin demonstrate that modern organic chemistry can be much more than just a handmaiden of biology and medicine. Further details on the relatively simple, though ingeniously designed, golfomycin are reported by K. C. Nicolaou et al. on page 1064. The picture was produced by Michael Pique and William Ogilvie and the DNA model by Thomas Maecke, all of the Research Institute of Scripps Clinic.