Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. Engl. 4/1992)
The cover picture shows an overlay of ten structures obtained from molecular dynamics simulations of the ligand-free protein FKBP which binds FK506; only the positions of the α-carbon atoms were calculated. Although large sections of the protein are structurally invariant, for example an α-helical portion (red), there are also flexible sections (blue and green) that are important in ligand binding. FK506 and other immunosuppressives are the subject of intense research as they have medical significance. M. K. Rosen and S. L. Schreiber give a summary of this fascinating area which draws on topics from organic chemistry to molecular immunology (p. 384 ff.).