Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 23

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

Cover Picture (Angew. Chem. Int. Ed. Engl. 6/1993)

32_06/1993The cover picture shows schematically the β-spiral structure of poly(GVGVP) (left) and the polypeptides designed from it, containing Glu residues (red) and hydrophobic Phe residues (white and pink). The optimal arrangement of the Phe residues about the Glu residues for the spiral structure in the polypeptide on the right, which contains three pentamers per turn of the β-spiral, gives the Glu residues of this polypeptide in water a pKa of 8.1, whereas the same residue that is, however, incorporated randomly into 20 % of the pentamers in the second peptide from the left has a pKa of 4.3. This example of the effect of the interplay between polar and apolar groups on hydration shows the extent to which such characteristics can influence the physical and chemical properties of polymeric structures, including protein folding. Such effects contribute to a better understanding of phenomena such as muscle contraction in living organisms. More on this fascinating research field is related in D. W. Urry's review on p. 819 ff.

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