Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

Cover Picture (Angew. Chem. Int. Ed. Engl. 4/1994)

33_04/1994The cover picture shows a balance with 1.5010 g of the enantiomerically pure, chiral ketone whose formula is given on the right-hand side of the picture. This compound was synthesized on a preparative scale by the antibody-catalyzed enantioselective hydrolysis of the enol ether shown on the left-hand side. The monoclonal antibody was raised against a hapten (general structure in the box) which is an analogue of the transition state depicted at the top. Thus, catalytic antibodies (see for example the highlight by C. Leumann last year: Angew. Chem. 1993, 105, 1352; Angew. Chem. Int. Ed. Engl. 1993, 32, 1291) can be considered as practical tools for preparative chemistry. J.-L. Reymond, J.-L. Reber, and R. A. Lerner give details on upscaling on pp. 475–477.

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