Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. Engl. 10/1994)
The cover picture provides a view into the otherwise closed measurement cell of a luminometer used routinely for chemiluminescent immunoassays in clinical laboratories. The sample tube containing a chemiluminescent substance is situated in front of the highly sensitive detector of a photomultiplier. The substances that trigger the emission of light are injected immediately prior to measurement. The structural formula shows the proposed. light-emitting dioxetane intermediate of the N-methylacridinium-9-(N-sulfony1)carboxamide derivative which decays to N-methylacridone. More about luminescent labels can be found in the review by A. Mayer and S. Neuenhofer on p. 1044 ff.