Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 30

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, Zeitschrift für Chemie

Cover Picture (Angew. Chem. Int. Ed. Engl. 10/1994)

33_10/1994The cover picture provides a view into the otherwise closed measurement cell of a luminometer used routinely for chemiluminescent immunoassays in clinical laboratories. The sample tube containing a chemiluminescent substance is situated in front of the highly sensitive detector of a photomultiplier. The substances that trigger the emission of light are injected immediately prior to measurement. The structural formula shows the proposed. light-emitting dioxetane intermediate of the N-methylacridinium-9-(N-sulfony1)carboxamide derivative which decays to N-methylacridone. More about luminescent labels can be found in the review by A. Mayer and S. Neuenhofer on p. 1044 ff.

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