Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 19

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Cover Picture (Angew. Chem. Int. Ed. Engl. 21/1994)

33_21/1994The cover picture shows probably the most densely oxygenated complex fragment of a natural product yet synthesized—C10H12O11! The central triol–triacid “core” (space-filling model at the top)of the fungal metabolite zaragozic acid A/squalestatin S1(structural formula and space-filling model at the bottom) is depicted. Showing unprecedented promise as a medicinally usefull inhibitor of squalene synthase (the enzyme controlling the first committed step in the biosynthesis of cholesterol), zaragozic acid A has attracted much attention in biological and chemical cirles. The synthesis of the central core and tthe first total synthesis of zaragozic acid A/squalestatin S1–another race is over—are described by K. C. Nicolaou et al. on p. 2184ff, 2190ff. (Red: oxygen, black: carbon, white: hydrogen; photograph: L. Gomez-Paloma, The Scripps Research Institute)

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