Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 33

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Cover Picture (Angew. Chem. Int. Ed. Engl. 4/1996)

35_04/1996The cover picture shows the catalytic asymmetric aminohydroxylation (AA) of alkenes in action. Methyl cinnamate can be transformed directly into a derivative of the taxol side chain with the catalyst system K2OsO2(OH)4 and a phthalazine ligand; Chloramine T serves as the nitrenoid source. Either enantiomer can be produced at will by selection of the appropriate ligand. The asymmetric aminohydroxylation (AA) follows the development of the asymmetric epoxidation (AE) and the asymmetric dihydroxylation (AD)—three reactions whose importance for organic synthesis cannot be overstated. Li, Chang, and Sharpless report more on the new catalytic AA on p. 451 ff. (The cover picture was created by Michael E. Pique, The Scripps Research Institute, La Jolla, CA, USA.)

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