Angewandte Chemie International Edition
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Cover Picture (Angew. Chem. Int. Ed. Engl. 6/1996)
The cover picture shows the structural formula of a uracil dimer (white) substituted with flavin units (yellow) and superimposed on a photograph of a solar eclipse (printed with permission from Eugene Aeppli, Zurich). This dimer was used to model the light-induced DNA repair reaction—the reversion of pyrimidine dimers, which are photoproducts formed on irradiation of DNA with UV light. For cleavage of the uracil dimer with light of longer wavelength (366 nm), the flavin substituents must be in reduced form; this is also a prerequisite for repair with DNA photolyase. T. Carell et al. report more on these model studies on p. 620 ff.