Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. Engl. 20/1996)
The cover picture shows an everyday application of the combinatorial principle—the door of a safe! The four knobs of the combination lock are analogous to the four different groups R1–R4 attached to a small organic molecule. The illustration underlines the tremendous number of compounds possible by varying relatively few substituents. Combinatorial methods can provide access to every possible combination, and the correct solution provides access to a valuable target.