Angewandte Chemie International Edition
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Cover Picture (Angew. Chem. Int. Ed. Engl. 20/1997)
The cover picture shows a model for the selective incorporation and localization of lipopeptides and lipid-modified proteins in the plasma membrane of cells. The lipopeptides were introduced into the cell by microinjection or membrane fusion. According to this model, peptides and proteins which contain S-farnesylated cysteine residues can diffuse freely between different subcellular membranes until they are additionally S-acylated in a membrane compartment. The now doubly lipid-modified peptide/protein can no longer be transferred between different membranes and is localized in the membrane where S-acylation takes place, here the plasma membrane. More on this proposed mechanism and how it was approached by a combination of techniques from organic synthesis, biophysics, and cell biology can be found on pages 2238 ff in the contribution from the groups of Waldmann, Wittinghofer, and Silvius.