Angewandte Chemie International Edition
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Cover Picture (Angew. Chem. Int. Ed. Engl. 21/1997)
The cover picture shows at the top left corner a space-filling model on an α-cyclodextrin molecule containing a xenon atom in its hydrophobic pocket. By application of optical pumping, a large nuclear-spin polarization of the xenon atom can be achieved, which can be transferred by cross-relaxation to 1H nuclei near xenon binding sites. This process, dubbed “spin polarization induced nuclear overhauser effect” (SPINOE), permits selective enhancement of NMR signals for protons in the interior of the pocket. A section of a SPINOE NMR spectrum of dehydrated α-cyclodextrin after introduction of laser-polarized xenon is shown at the bottom. Read more about this promising method in the contribution from A. Pines et al. on pages 2368–2370.