Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. 18/1998)
The cover picture shows the X-ray structure of the active site of an aldolase antibody which enantioselectively catalyzes aldol and retro-aldol reactions. With the latter reaction, the first kinetic resolution of β-hydroxyketones (aldols) has been achieved. Since either antibody-catalyzed aldol or retro-aldol reactions are possible, both enantiomers of the β-hydroxyketones can be prepared with a single antibody. Details of these kinetic resolutions are reported by C. F. Barbas III and R. A. Lerner et al. on pages 2481–2484. The cover image was generated by M. E. Pique, G. Zhong, and A. Heine of The Scripps Research Institute.