Angewandte Chemie International Edition

Cover image for Vol. 57 Issue 9

Editor: Neville Compton, Deputy Editor: Frank Maass. Editor Emeritus: Peter Gölitz

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

Cover Picture (Angew. Chem. Int. Ed. 1/2/1999)

38_1-2/1999The cover picture shows a symbolic representation of the progression from biological to chemical diversity. Nature produces molecules with a wide number of complex biological functions (for example, the antibody molecule depicted at the top left) by synthesizing large, diverse collections of chemical structures and screening or selecting for a desired function. Today this same combinatorial approach is being used to synthesize large libraries of small organic compounds, natural products, peptides, proteins, nucleic acids, and even inorganic materials. With high-throughput screening of these compound libraries, molecules with novel or enhanced properties (depicted by a thin-film 1024-membered library of luminescent metal oxides at the bottom right) are found which are difficult and, in many cases, impossible to obtain with traditional synthetic approaches. A broad overview of this fascinating area of research is provided by David R. Liu and Peter G. Schultz on pages 36–54.

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