Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. 15/1999)
The cover picture shows the original petri dish of A. Fleming in which the action of penicillin against certain strains of bacteria was discovered. The structures of penicillin and the antibacterial agent clarithromycin, both of which are in danger of being rendered obselete by the encroachment of antibiotic activity, are superimposed in the background. In the foreground is shown the structure of vancomycin, which together with its sister antibiotic teicoplanin, are indespensible weapons—and in some cases the last resort—in fighting drug-resistant bacterial strains. More about the chemistry, biology, and medicine of the glycopeptide antibiotics, namely, vancomycin, teicoplanin, the hundreds of other related natural products discovered, and the thousands of semisynthtic analogues prepared, is reported by K. C. Nicolaou et al. on pages 2096 ff.