Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture (Angew. Chem. Int. Ed. 21/1999)
The cover picture shows the structure of the fungal metabolite fumagillin and the symbolic presentation of an ets-1 antisense oligodeoxynucleotide (ODN). Fumagillin is known to be a potent inhibitor of the formation of new blood vessels (angiogenesis). The angiostatic effect of the ets-1 antisense ODN in vivo is clearly visible on the chick embryo depicted at the bottom. In contrast to a normally developed embryo (shown at the top), on which the sense ODN was applied as a control, the number of blood vessels is drastically reduced. N. Wernert, A. Giannis et al. (pp. 3228–3231) have also proven for the first time that the inhibition of the biosynthesis of the transcription factor Ets-1 represents a central aspect of the angiostatic effect of fumagillin.