Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 39

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Cover Picture: One Century of Aryne Chemistry (Angew. Chem. Int. Ed. 5/2003)

42_05/2003A century of aryne chemistry has not dampened the interest in this class of reactive intermediates. The cover picture shows the structure of a calicheamicin–DNA complex, the “warhead” of which is a cyclic enediyne unit (highlighted). The biological activity of the enediyne cytostatics is based on the depicted Bergman cyclization of the enediyne to a didehydrobenzene biradical. More about these short-lived species is given by Sander et al. on pp. 502 ff.

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