Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

Cover Picture: Catalytic Enantioselective Synthesis of Oxindoles and Benzofuranones That Bear a Quaternary Stereocenter (Angew. Chem. Int. Ed. 33/2003)

42_33/2003The enantioselective rearrangement of O-acylated benzofuranones and oxindoles with the generation of a quaternary stereocenter at C3 of the heterocycle is catalyzed by a planar-chiral derivative of 4-dimethylaminopyridine. As shown in the cover picture, the catalyst itself is red, whereas the resting state of the complex during the rearrangement of benzofurans is a green ion pair. Diazonamide A, an oxindole-derived natural product with potent anticancer activity, is shown in the background. More on the asymmetric syntheses of such heterocycles is provided by I. D. Mills and G. C. Fu on page 3921 ff.

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