Angewandte Chemie International Edition
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Cover Picture: DNA Topoisomerase Inhibitor Acutissimin A and Other Flavano-Ellagitannins in Red Wine (Angew. Chem. Int. Ed. 48/2003)
Human DNA topoisomerase II is inhibited in vitro by acutissimin A, a flavano-ellagitannin, with an activity much higher than that of the clinically used antitumor drug etoposide. Acutissimin A is formed by a non-enzymatic, yet diastereoselective, condensation reaction occurring during the aging of red wine in oak barrels. S. Quideau et al. report its high-yielding semi-synthesis in their Communication on page 6012 ff.