Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Pentanuclear Platinum(ii) Macrocycles with Nucleobases (Angew. Chem. Int. Ed. 10/2004)
Metallocalixarenes such as the pentanuclear platinum(ii) macrocycle shown in the cover picture, are prepared from a cisplatin analogue with tertiary amine ligands and the nucleobase uracil or thymine. The platinum(ii) complex used in the synthesis of the macrocycle has a significant cytostatic activity as a result of its ability to bind to DNA. The background shows a crystal of calf thymus DNA. More details can be found in the Communication by M. J. Rauterkus and B. Krebs on page 1300 ff.