Angewandte Chemie International Edition

Cover image for Vol. 54 Issue 36

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

Cover Picture: Excess Electron Transport Through DNA: A Single Electron Repairs More than One UV-Induced Lesion (Angew. Chem. Int. Ed. 14/2004)

43_14/2004Electron-catalyzed repair of thymine dimers in double-stranded DNA is described by B. Giese, T. Carell, O. Schiemann, and co-workers on page 1848 ff. Transport of an electron from a remote modified thymine base through DNA occurs in a multistep hopping process. When the electron meets a thymine dimer, which is generated by photocycloaddition of adjacent thymine residues, the two thymine bases are repaired through a retro-cyclization reaction, while the electron continues along the DNA.

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