Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Excess Electron Transport Through DNA: A Single Electron Repairs More than One UV-Induced Lesion (Angew. Chem. Int. Ed. 14/2004)
Electron-catalyzed repair of thymine dimers in double-stranded DNA is described by B. Giese, T. Carell, O. Schiemann, and co-workers on page 1848 ff. Transport of an electron from a remote modified thymine base through DNA occurs in a multistep hopping process. When the electron meets a thymine dimer, which is generated by photocycloaddition of adjacent thymine residues, the two thymine bases are repaired through a retro-cyclization reaction, while the electron continues along the DNA.