Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: A Droplet-Based, Composite PDMS/Glass Capillary Microfluidic System for Evaluating Protein Crystallization Conditions by Microbatch and Vapor-Diffusion Methods with On-Chip X-Ray Diffraction (Angew. Chem. Int. Ed. 19/2004)
Protein crystals can be grown inside nanoliter droplets in a composite polydimethylsiloxane/glass microfluidic device. R. F. Ismagilov and co-workers describe in their Communication on page 2508 ff. how this approach can be used to screen conditions for protein crystallization by both microbatch and vapor-diffusion methods. The quality of the crystals grown in the device was evaluated directly from the X-ray diffraction pattern shown in the background.