Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 50

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

Cover Picture: Single DNA Rotaxanes of a Transmembrane Pore Protein (Angew. Chem. Int. Ed. 23/2004)

43_23/2004A single rotaxane structure created by threading and capturing a DNA–poly(ethylene glycol) (DNA–PEG) strand inside an α-hemolysin (α-HL) transmembrane pore protein is described by M. R. Ghadiri and co-workers on page 3063 ff. The DNA–α-HL rotaxanes exhibit a reversible two-state switching capacity that depends on the applied transmembrane potential, the orientation, and the method of threading and capture used. Functional rotaxanes might provide a means for critically assessing the feasibility of the pore-mediated single-molecule DNA sequencing hypothesis.

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