Angewandte Chemie International Edition
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Cover Picture: Structural Revision and Total Synthesis of Azaspiracid-1, Part 1: Intelligence Gathering and Tentative Proposal (Angew. Chem. Int. Ed. 33/2004)
The mussel toxin azaspiracid-1, which was isolated from Mytilus edulis, has baffled chemists for quite some time, as the originally proposed structure was incorrect. In their Communications on pages 4312 ff. and 4318 ff., Nicolaou and co-workers describe how they determined the structure and absolute configuration of the molecule through degradation studies and total synthesis. The synthesis should render this valuable, but scarce, substance available for much-needed biotoxin assays and biological investigations.