Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 14

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

Cover Picture: Structural Revision and Total Synthesis of Azaspiracid-1, Part 1: Intelligence Gathering and Tentative Proposal (Angew. Chem. Int. Ed. 33/2004)

43_33/2004The mussel toxin azaspiracid-1, which was isolated from Mytilus edulis, has baffled chemists for quite some time, as the originally proposed structure was incorrect. In their Communications on pages 4312 ff. and 4318 ff., Nicolaou and co-workers describe how they determined the structure and absolute configuration of the molecule through degradation studies and total synthesis. The synthesis should render this valuable, but scarce, substance available for much-needed biotoxin assays and biological investigations.

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