Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Total Synthesis and Configurational Assignment of (−)-Dictyostatin, a Microtubule-Stabilizing Macrolide of Marine Sponge Origin / Total Synthesis of (−)-Dictyostatin: Confirmation of Relative and Absolute Configurations (Angew. Chem. Int. Ed. 35/2004)
Sponging off nature is a reliable way to find promising drug leads: (−)-Dictyostatin, which was isolated from the marine sponge Corallistidae, is a novel microtubule-stabilizing agent that could be useful against multidrug-resistant tumors. In their Communications on pages 4629 ff. and 4634 ff., the groups of I. Paterson and D. P. Curran describe the total synthesis of this challenging target, thus establishing unequivocally the relative and absolute configuration of the macrolactone and opening the way to useful amounts of the drug and designed analogues. The Photo of the sponge was provided by Harbor Branch Oceanographic Institution.
Also of Interest
The advantages of modern dual-activation catalysts with two or more active centers in asymmetric synthesis are discussed by J.-A. Ma and D. Cahard in their Review on page 4566 ff.
Molecular Dynamics Simulations
What sequence of molecular events occurs in the bipropellant monomethylhydrazine/nitrogen tetroxide in the “cold prereaction” before ignition? I. Frank and co-workers address this question with molecular dynamics calculations on page 4586 ff.
The self-organization of rigid rodlike alkali-metal carboxylates into liquid-crystal phases with complex superstructures is described by C. Tschierske and co-workers on page 4621 ff.