Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Palladium-Catalyzed Enantioselective Domino Reaction for the Efficient Synthesis of Vitamin E (Angew. Chem. Int. Ed. 2/2005)
A domino reaction consists of several consecutive transformations in which the functions required for one reaction are generated in the preceding bond-formation or fragmentation step. L. F. Tietze et al. applied this concept to the synthesis of vitamin E described on page 257 ff. They developed an enantioselective palladium-catalyzed process for the construction of the chiral chroman framework with 96 % ee and concomitant introduction of part of the side chain.
Also of Interest
The demand for an electrophilic fluorinating agent that is easy to handle, stable, and highly reactive ultimately led to the development of selectfluor. C.-H. Wong and co-workers discuss the applications and reaction mechanisms of this reagent in their Review on page 192 ff.
Fluorine substitution can have a dramatic effect on the properties of organic compounds, including pharmaceuticals and materials. Methods for the synthesis of organofluorine compounds are reviewed by T. Hiyama and M. Shimizu on page 214 ff.
In their Communication on page 234 ff. P. A. Troshin, S. I. Troyanov et al. describe a highly chlorinated stable fullerene consisting of a cylinder-shaped carbon cage.