Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 40

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

Cover Picture: Highly Efficient Dynamic Kinetic Resolution of Azlactones by Urea-Based Bifunctional Organocatalysts (Angew. Chem. Int. Ed. 5/2005)

44_05/2005Ureas have come a long way from Wöhler's preparation of urea from ammonium cyanate in 1828 to the chiral ureas that play an important role in asymmetric organocatalysis today. In their Communication on page 807 ff. Berkessel et al. report the use of bifunctional urea-based organocatalysts for the highly enantioselective dynamic kinetic resolution of azlactones. The cover picture shows the hydrogen-bonded supramolecular aggregate formed from the urea catalyst and an azlactone substrate (graphic: K. Etzenbach-Effers).

Read Full Text  | Table of Contents

Also of Interest

Cross-Coupling Reactionsfor001

A. C. Frisch and M. Beller give an account of C-C bond-forming reactions that involve non-activated alkyl halides in their Minireview on page 674 ff.

Drug Researchfor002

New approaches in the search for antiparasitic drugs are based on enzyme inhibitors that suppress the antioxidative systems in the parasite. In their Review on page 690 ff., R. L. Krauth-Siegel, H. Bauer, and R. H. Schirmer describe the current trends in this field of research.

Prodrug Dendrimersfor003

In their Communication on page 716 ff. D. Shabat et al. present the advantages of incorporating three drug molecules in the same prodrug platform to effectively allow triple drug therapy in a single molecule.