Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: On the Remarkable Antitumor Properties of Fludelone: How We Got There (Angew. Chem. Int. Ed. 19/2005)
Synthetic and biological studies of epothilone B (isolated from a myxobacterium) led to the discovery of a 26-trifluoro analogue that is remarkably active in treating xenograft tumors in nude mice. These findings underscore the potential of using natural products as leads, in conjunction with directed total synthesis, in the quest for new drugs. S. J. Danishefsky and co-workers present their synthetic strategy along with biological data in their Minireview on page 2838 ff.
Also of Interest
Many cellular processes involve proline-mediated protein–protein interactions. In their Review on page 2852 ff. L. J. Ball, H. Oschkinat, et al. describe the structural characteristics of the binding domains concerned and the complexes formed.
T. Hyeon et al. obtain 6 to 13 nm monodispered magnetic iron oxide nanoparticles by a technique that they report in their Communication on page 2872 ff. The method is a variation of a seed-mediated growth approach.
Quasi-parallel nanowires that originate from well-controlled single particle sites are formed in the low-temperature chemical vapor deposition process described by H. Dai and co-workers in their Communication on page 2925 ff.