Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Nanoparticle PCR: Nanogold-Assisted PCR with Enhanced Specificity (Angew. Chem. Int. Ed. 32/2005)
Favorable binding of gold nanoparticles to single-stranded DNA decreases the likelihood of mispair formation during annealing and clearly increases the specificity and yield of PCR, one of the most important standard methods of molecular biology. In their Communication on pp. 5100 ff., Z. Zhang, C. Fan, J. Hu, and co-workers report on this promising field of biotechnology. (Xiaobin Wang assisted in the production of this image.)
Also of Interest
Cationic Boron Compounds
The possible synthetic uses of boronium, borenium, and borinium ions are increasing rapidly. W. E. Piers et al. explore the chemistry of these reactive electrophiles in their Review on page 5016 ff.
In their Communication on pp. 5038 ff., V. S.-Y. Lin et al. introduce a model system for the site-specific delivery of drugs. For this purpose, mesoporous MCM-41-type silica nanorods (MSNs) covered with superparamagnetic iron oxide nanoparticles were used.
Helical bis(merocyanin)dye nanorods organize themselves through an inversion of the exciton chirality as well as through structural changes that occur in the transition from kinetic to thermodynamic self-assembly. For more information, see the Communication by F. Würthner et al. on pp. 5071 ff.