Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Two-Component Graded Deposition of Biomolecules with a Double-Barreled Nanopipette (Angew. Chem. Int. Ed. 42/2005)
The persistence of Edgar Degas is illustrated in the formation of highly complex, graded, ‘two-color’ images on the submicron scale. Two species can be delivered independently from a single pipette through the use of scanning ion-conductance distance control. The cover picture shows biological molecules being delivered in air through a liquid meniscus at the tip of a double-barreled nanopipette (Salvador Dali, not to scale, is shown painting the Degas Dancers with a nanopipette) as described by D. Klenerman et al. in their Communication on page 6854 ff.
Also of Interest
In many reactions catalysts with bidentate ligands yield the best results. In his Minireview on p. 6816 ff., B. Breit describes how these chelates can be emulated by two monodentate ligands held together by attractive interactions.
Natural Product Discovery
How are leads for drug development identified? In their Review on page 6828 ff., H. B. Bode and R. Müller describe the identification and manipulation of biosynthetic pathways towards new natural products and derivatives potentially suitable for this task.
In their Communication on page 6848 ff., L. F. Dahl, E. G. Mednikov, and co-workers describe the synthesis and structural characterization of two new large palladium–carbonyl–triethylphosphine clusters that contain Pd52 and Pd66 cores.