Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

45_08/2006Cover Picture: Molecular Recognition of a Three-Way DNA Junction by a Metallosupramolecular Helicate (Angew. Chem. Int. Ed. 8/2006)

Metallosupramolecular helicates with trigonal-antiprismatic geometry thread through and fit perfectly into the central hydrophobic cavity of a three-way DNA junction. Six hydrophobic rings of the drug stack on six DNA bases, with three more sandwiched in the minor grooves. This work reveals and enables a new approach to targeting DNA and specifically DNA junctions. For more details, see the Communication by M. Coll, M. J. Hannon, and co-workers on page 1227 ff.

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Polymeric carrier systems enable the optimization and transport of low-molecular-weight drugs, proteins, and oligonucleotides. Current developments in polymer therapeutics are given by R. Haag and F. Kratz in their Review on page 1198 ff.


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