Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 31

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

45_08/2006Cover Picture: Molecular Recognition of a Three-Way DNA Junction by a Metallosupramolecular Helicate (Angew. Chem. Int. Ed. 8/2006)

Metallosupramolecular helicates with trigonal-antiprismatic geometry thread through and fit perfectly into the central hydrophobic cavity of a three-way DNA junction. Six hydrophobic rings of the drug stack on six DNA bases, with three more sandwiched in the minor grooves. This work reveals and enables a new approach to targeting DNA and specifically DNA junctions. For more details, see the Communication by M. Coll, M. J. Hannon, and co-workers on page 1227 ff.

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Also of Interest


The molecular recognition between an external signal and a receptor is transduced allosterically to catalytically amplified chemical information. E. V. Anslyn and L. Zhu outline this approach in their Minireview on page 1190 ff.

Medicinal Chemistryfor002

Polymeric carrier systems enable the optimization and transport of low-molecular-weight drugs, proteins, and oligonucleotides. Current developments in polymer therapeutics are given by R. Haag and F. Kratz in their Review on page 1198 ff.

Metathesis Catalystsfor003

In their Communication on page 1216 ff., C. Copéret and co-workers describe the preparation of a silica-supported Mo–carbene catalyst for olefin metathesis and how its performance compares relative to its molecular equivalent.