Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 10

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

45_19/2006Cover Picture: Proteolytic Actuation of Nanoparticle Self-Assembly (Angew. Chem. Int. Ed. 19/2006)

Sterically shielded ...... nanoparticles diffuse freely in solution and biological fluids until proteases expressed by cancer cells trigger them to self-assemble. In their Communication on page 3161ff., S. N. Bhatia and co-workers show that complimentary Fe3O4 nanoparticle binding is inhibited by the attachment of protease-cleavable polymers. Cleavage of these polymers triggers “latent” nanoparticles to form multimeric assemblies with emergent properties.

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Also of Interest

Hybridization and Electron Configurationfor001

In their Essay on page 3012 ff., S. Alvarez and J. Cirera describe how the splitting of the d-orbital manifold and the existence of low-spin states in putative tetrahedral complexes can be explained by the hybridization of the orbitals.

Charges on Proteinsfor002

G. M. Whitesides and co-workers consider in their Review on page 3022 ff. the question of the function of charged amino acids on proteins, and present techniques that have proved useful in the search for the answer.


A method for DNA purification on a chip has been developed by U. Lehmann et al. This system employs magnetic microparticles and is suitable for dilute concentrations of raw cell samples (see their Communication on page 3062 ff.).