Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Highly Enantioselective Aza-Baylis–Hillman Reaction in a Chiral Reaction Medium (Angew. Chem. Int. Ed. 22/2006)
Chiral solvents are capable of inducing high enantioselectivities in asymmetric reactions after all. Functionalized chiral ionic liquids are particularly suitable for this purpose as they can interact strongly (e.g., through electrostatic interactions and hydrogen bonding) with substrates and/or intermediates. W. Leitner and co-workers show in their Communication on page 3689 ff. that this concept can be used for the aza-Baylis–Hillman reaction to achieve products with up to 84% ee.
Also of Interest
In their Review on page 3584 ff., J. M. Shreeve et al. present recent developments in the field of nitrogen-rich energetic salts and ionic liquids. The properties of the corresponding molecular compounds are a benchmark for this emerging substance class.
Bioinorganic Chemistry Evidence for the formation of a nickel–carbon bond at the active site of the enzyme involved in the key step of methanogenesis is described by J. Harmer, B. Jaun, and co-workers in their Communication on page 3602 ff.