Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 23

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

45_23/2006Cover Picture: Identification of Pyridinylpyrimidines as Inhibitors of Human Methionine Aminopeptidases (Angew. Chem. Int. Ed. 23/2006)

The evolutionarily conserved enzymes, the methionine aminopeptidases (MetAPs), remove N-terminal methionine during protein synthesis. J. O. Liu et al. describe in their Communication on page 3772 ff. a new class of inhibitors for MetAPs and the crystal structure of the inhibitor complexed with MetAP1. These findings should facilitate the development of MetAP1-specific inhibitors that can serve as molecular probes for the function of MetAP1 and as potential leads for inhibitors of cancer cell growth.

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Also of Interest

Nobel Lecturesfor001

Metathesis reactions take center stage in the Nobel Prize lectures from Yves Chauvin, Richard R. Schrock, and Robert H. Grubbs. The prizewinners present first-hand accounts of their discoveries in three Reviews beginning on page 3740 ff.

Supramolecular Chemistryfor002

The cyclo-Ni10S20 toroid adopts a circular or ellipsoidal configuration depending on the presence or absence of an encapsulated guest molecule. In their Communication on page 3768 ff., K. Tatsumi and co-workers report their findings on the basis of X-ray crystallography.

Organic Synthesisfor003

S. Kobayashi and co-workers discuss two methods for the construction of carbon frameworks. They describe the addition of enecarbamates to aldehydes in the first of their Communications on page 3814 ff., while on page 3816 ff. the focus is aza-Diels–Alder reactions of acyl hydrazones.