Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 7

Chefredakteur: Peter Gölitz, Stellvertreter: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

45_35/2006Cover Picture: Pd-Catalyzed α-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides: A Synergistic Effect of Two Metal Fluorides as Additives (Angew. Chem. Int. Ed. 35/2006)

A synergistic combination of two metal fluoride additives is the key to the palladium-catalyzed coupling of aryl halides with silyl enol ethers. In their Communication on page 5852 ff., J. G. Verkade, J. F. Hartwig, and co-workers discuss the use of this approach to prepare α-aryl ketones from both cyclic and acyclic silyl enol ethers and a wide range of aryl bromides and chlorides. The cover picture depicts the difference in the yields from reactions with one and with two additives.

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Also of Interest

Octacyclene Synthesisfor001

The construction of eight-membered rings is synthetically demanding. Ring-closing metathesis can be the key to success, as J. Rodriguez and A. Michaut describe in their Minireview on page 5740 ff. with its application to the synthesis of octacyclenes.


Leuchs's anhydrides, α-amino acid N-carboxyanhydrides, have been used to synthesize peptide block copolymers and liquid-crystalline polypeptides through ring-opening polymerization. In the Review on page 5752 ff., H. R. Kricheldorf discusses new developments and the application of polypeptides as drug carriers.

Spin-Crossover Materialsfor003

In their Communication on page 5786 ff., A. Bousseksou, G. Molnár et al. describe a successful multilayer assembly of [Fe(pyrazine){M(CN)4}] (M=Ni, Pd, or Pt) thin films, which display spin-crossover phenomenon and provide a novel platform for the construction of devices.