Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Massively Parallel Dip–Pen Nanolithography with 55 000-Pen Two-Dimensional Arrays (Angew. Chem. Int. Ed. 43/2006)
Massively parallel dip–pen nanolithography is possible when 55 000 AFM cantilevers are used to write molecules directly onto a surface. An optical micrograph shows the surface after etching (cover picture, left), and each round feature is a miniature image of the face of Thomas Jefferson (AFM image, right), who helped develop the polygraph, a duplicator based on an array of pens. For more information on the new technique see the Communication by C. A. Mirkin and co-workers on page 7220 ff.
Also of Interest
Capillary NMR Spectroscopy
In their Minireview on page 7122 ff., F. C. Schroeder and M. Gronquist discuss capillary NMR technology, its application in the characterization and screening of mass-limited small-molecule and protein samples, and its use in combination with other analytical methods.
Cascade reactions are far from trivial but worth the effort, as K. C. Nicolaou et al. discuss in their Review on page 7134 ff. The advantages of this approach are highlighted with a multitude of applications in total synthesis.
Mass Spectrometry and Imaging
In their Communication on page 7188 ff., R. G. Cooks and co-workers introduce desorption electrospray ionization (DESI) mass spectrometry as a technique to generate images of rat brain tissue under ambient conditions and two-dimensional maps of specific compounds therein.