Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 40

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

45_46/2006Cover Picture: Oxetanes as Promising Modules in Drug Discovery (Angew. Chem. Int. Ed. 46/2006)

The oxetane ring is an orphan heterocycle in medicinal chemistry. In their Communication on page 7736 ff., M. Rogers-Evans, E. M. Carreira, and co-workers show that this structural motif can improve key physico- and pharmacochemical properties of an underlying scaffold. An “oxetane scan” within a series of lipophilic tertiary amine derivatives was performed to probe the influence of the oxetane ring on selected compound properties.

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Asymmetric Catalysisfor001

Chiral ferrocene ligands have emerged as versatile reagents for asymmetric catalysis. With an emphasis on newly developed ligands and reactions, the Review by J. C. Carretero and co-workers on page 7674 ff. details the progress of the last four years.


Molecular Devicesfor002

In their Communication on page 7716 ff., N. Sugimoto and co-workers discuss the development of simple DNA logic gates that are sensitive to two input signals, M+ and H+, and allow fast readout of the fluorescence output signal.


Mn19 Single-Molecule Magnets

G. Christou, A. J Tasiopoulos, and co-workers describe in their Communication on page 7722 ff. the open framework structures of two manganese carboxylate 3D coordination polymers with nanometer-sized cavities whose Mn19 units behave as single-molecule magnets.for003

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