Angewandte Chemie International Edition

Cover image for Vol. 56 Issue 40

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPhotoChem, ChemPlusChem, Zeitschrift für Chemie

45_46/2006Cover Picture: Oxetanes as Promising Modules in Drug Discovery (Angew. Chem. Int. Ed. 46/2006)

The oxetane ring is an orphan heterocycle in medicinal chemistry. In their Communication on page 7736 ff., M. Rogers-Evans, E. M. Carreira, and co-workers show that this structural motif can improve key physico- and pharmacochemical properties of an underlying scaffold. An “oxetane scan” within a series of lipophilic tertiary amine derivatives was performed to probe the influence of the oxetane ring on selected compound properties.

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Also of Interest

Asymmetric Catalysisfor001

Chiral ferrocene ligands have emerged as versatile reagents for asymmetric catalysis. With an emphasis on newly developed ligands and reactions, the Review by J. C. Carretero and co-workers on page 7674 ff. details the progress of the last four years.

Molecular Devicesfor002

In their Communication on page 7716 ff., N. Sugimoto and co-workers discuss the development of simple DNA logic gates that are sensitive to two input signals, M+ and H+, and allow fast readout of the fluorescence output signal.

Mn19 Single-Molecule Magnets

G. Christou, A. J Tasiopoulos, and co-workers describe in their Communication on page 7722 ff. the open framework structures of two manganese carboxylate 3D coordination polymers with nanometer-sized cavities whose Mn19 units behave as single-molecule magnets.for003