Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 23

Editor: Peter Gölitz, Deputy Editors: Neville Compton, Haymo Ross

Online ISSN: 1521-3773

Associated Title(s): Angewandte Chemie, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemPlusChem, Zeitschrift für Chemie

46_04/2007Cover Picture: Total Synthesis of Paliurine F (Angew. Chem. Int. Ed. 4/2007)

The sedative paliurine F, which was isolated from the roots of Paliurus ramossisimus, is part of a huge family of natural products that display interesting biological effects and possess an especially appealing and challenging macrocyclic structure. In their Communication on page 572 ff., G. Evano and co-workers describe the synthesis of one of these cyclopeptide alkaloids, paliurine F, using a route that showcases the recent advances in copper(I)-mediated coupling reactions.

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In their Minireview on page 498 ff., M. Oestreich and S. Rendler describe enantioselective 1,2- and 1,4-reductions catalyzed by copper hydride complexes. These homogeneous or heterogeneous reactions hold promise as versatile synthetic methods.

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In their Review on page 506 ff., T. Ikeda et al. describe advances in the area of soft materials that can convert light into mechanical energy and are thus suitable for the construction of artificial muscles.

Proton-Transfer Cascadefor003

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