Angewandte Chemie International Edition
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Inside Cover: Bioinspired Design of Nanocages by Self-Assembling Triskelion Peptide Elements (Angew. Chem. Int. Ed. 12/2007)
Inspired by clathrin, a protein that assembles into closed-cage structures as a result of the unique triskelion conformation of its three pendant polypeptide chains, E. Gazit, S. Verma, and co-workers report in their Communication on page 2002 ff. on a synthetic tripodal conjugate with three dipeptide units radiating from a central core. The legs interdigitate to reveal highly spherical structures, as shown in the picture, in which guest molecules such as fluorescent dyes can be trapped and subsequently released.