Angewandte Chemie International Edition
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Cover Picture: Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligodipeptides and Oligodipeptoids Tagged with Triazines as Recognition Elements / Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligodipeptides Tagged with 2,4-Disubstituted 5-Aminopyrimidines as Recognition Elements (Angew. Chem. Int. Ed. 14/2007)
2,4-Dioxo- and 2,4-diamino derivatives of the 5-aminopyrimidine nucleus, which are attached to an oligodipeptide backbone, display inverse base-pairing strengths with complementary DNA and RNA compared to the corresponding 2,4-diamino- and 2,4-dioxotriazine derivatives. In their Communications on pages 2470 and 2478 ff., R. Krishnamurthy, A. Eschenmoser, and co-workers point to a remarkable correlation between pairing strength and ΔpKa values of pairs of complementary bases.
Also of Interest
Supramolecular Chemistry in Water
The Review by W. Verboom et al. on page 2366 ff. focuses on the formation and reactivity of supramolecular aggregates in aqueous media. Such media are the environments in which natural self-assembly processes occur.
In their Communication on page 2394 ff., J. L. Atwood and R. M. McKinlay demonstrate the assembly of six calixarene molecules by hydrogen bonding. The observed toroidal shape represents an exceptional topology for noncovalent assemblies.
The cavity shell of a molybdenum/tungsten-storage (Mo/WSto) protein acts as a polytopic host for noncovalently or weakly bonded polyoxotungstate guests. A. Müller, U. Ermler, and co-workers discuss this “biological supramolecular chemical system” in their Communication on page 2408 ff.